SYT1 Cancer Research Results

SYT1, Synaptotagmin 1: Click to Expand ⟱
Source:
Type:

SYT1 - Synaptotagmin 1

Abbreviation: SYT1, Synaptotagmin-1

Type: Presynaptic calcium sensor / synaptic vesicle protein / neurotransmitter-release regulator

Function: Synaptotagmin-1 is a major calcium sensor on synaptic vesicles that triggers rapid calcium-dependent vesicle fusion and neurotransmitter release through interactions with the SNARE machinery.

Alzheimer's Disease: ↓ Synaptic SYT1 expression or function is associated with impaired presynaptic vesicle release and synaptic dysfunction. Altered SYT1 levels have also been investigated in cerebrospinal fluid and blood as biomarkers of synaptic degeneration in Alzheimer's disease and mild cognitive impairment.

Favorable Direction in Alzheimer's Disease: ↑ Preservation or restoration of normal synaptic SYT1 expression/function is generally favorable.

Biomarker Note: Increased extracellular or CSF SYT1 may reflect synaptic injury and should not be interpreted the same way as increased functional SYT1 within intact presynaptic terminals.
Scientific Papers found: Click to Expand⟱
8494- MAG,    Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *PSD95?, *SYN1↑, *SYT1↑, *IL10↑, *TNF-α↓, *IL6↓, *Aβ42↓, *GFAP↓, *other↑, *cognitive↑, *NeuroI↓, *Aβ↓, *GSK‐3β↓, *NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Aβ42↓, 1,   GFAP↓, 1,   NeuroI↓, 1,   SYN1↑, 1,   SYT1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PSD95?, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,  
Total Targets: 15

Scientific Paper Hit Count for: SYT1, Synaptotagmin 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1844  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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