CLDN4 Cancer Research Results

CLDN4, Claudin-4: Click to Expand ⟱
Source:
Type:

CLDN4 (Claudin-4) — Integral membrane tight-junction protein involved in epithelial barrier function, cell polarity, and regulation of paracellular transport. CLDN4 can also participate in intracellular signaling outside of classical tight junctions and is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE).

Typical modulation in cancer: ↑ CLDN4 is common in many epithelial malignancies and may promote tumor growth, proliferation, EMT, stemness, invasion, and resistance to drug penetration. However, reduced CLDN4 can also accompany loss of epithelial differentiation and EMT in some contexts, so direction should be interpreted by tumor type and experimental setting.

Typical modulation in Alzheimer’s disease: No well-established Alzheimer’s disease-associated direction. CLDN4 is primarily relevant to epithelial tight-junction biology and cancer.
Scientific Papers found: Click to Expand⟱
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↓, 1,   GPx4↑, 1,   Iron↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Ferroptosis↓, 1,   JNK↓, 1,   p38↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,  

Migration(tgid=13) ⓘ

RAGE↓, 1,   TJ↑, 1,   ZO-1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1,   CLDN4↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: CLDN4, Claudin-4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1850  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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