GGT/CD224 Cancer Research Results

GGT/CD224, Gamma-Glutamyltransferase 1: Click to Expand ⟱
Source:
Type:

GGT1 (Gamma-Glutamyltransferase 1; GGT) — Cell-surface enzyme of the gamma-glutamyl cycle that hydrolyzes and transfers the gamma-glutamyl moiety of extracellular glutathione (GSH). GGT1 contributes to glutathione recycling, cysteine availability, redox homeostasis, xenobiotic metabolism, and cellular responses to oxidative stress.

Typical modulation in cancer: ↑ GGT1 is frequently associated with tumor progression, enhanced glutathione utilization, resistance to oxidative stress, and resistance to chemotherapy. By supporting cysteine recovery and intracellular GSH synthesis, elevated GGT1 can improve tumor antioxidant capacity. However, GGT activity can also generate reactive intermediates under some conditions, so redox effects may be context-dependent.

Typical modulation in Alzheimer’s disease: ↑ circulating GGT has been associated with increased oxidative stress and has been reported to be elevated in some Alzheimer’s disease cohorts. This is primarily considered a systemic oxidative-stress biomarker rather than a core AD-driving target.
Scientific Papers found: Click to Expand⟱
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt↓, 1,  

Migration(tgid=13) ⓘ

EMT↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALB↑, 1,   ALP↓, 1,   AST?, 1,   DBIL↓, 1,   IBIL↓, 1,   TBIL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GGT/CD224, Gamma-Glutamyltransferase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1858  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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