TRAF6 Cancer Research Results

TRAF6, TNF Receptor-Associated Factor 6: Click to Expand ⟱
Source:
Type:

TRAF6 (TNF Receptor-Associated Factor 6) — Signaling adaptor and RING-domain E3 ubiquitin ligase that mediates signaling downstream of Toll-like receptors (TLRs), IL-1 receptors, TNF receptor-superfamily members, and other immune receptors. TRAF6 catalyzes predominantly K63-linked polyubiquitination and promotes activation of TAK1, IKK/NF-κB, MAPK, inflammatory, survival, and stress-response pathways.

Typical modulation in cancer: ↑ TRAF6 is frequently tumor-promoting and can enhance NF-κB, MAPK, survival, proliferation, migration, invasion, inflammatory signaling, and treatment resistance. TRAF6 inhibition or downregulation is therefore generally considered anticancer, although effects can vary by tumor type and immune context.

Typical modulation in Alzheimer’s disease: ↑ TRAF6-mediated inflammatory signaling may contribute to neuroinflammation through TLR/IL-1/NF-κB pathways. Excessive TRAF6 activity is generally considered potentially detrimental in chronic neuroinflammatory states, although TRAF6 also participates in normal innate-immune and neuronal signaling.
Scientific Papers found: Click to Expand⟱
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IL17↓, 1,   IL23↓, 1,   MyD88↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TRAF6↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   Stroke↓, 1,  
Total Targets: 26

Scientific Paper Hit Count for: TRAF6, TNF Receptor-Associated Factor 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1862  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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