PROKR1 Cancer Research Results

PROKR1, Prokineticin Receptor 1; PKR1,GRP73: Click to Expand ⟱
Source:
Type:

PROKR1 (Prokineticin Receptor 1; PKR1) — Seven-transmembrane G-protein-coupled receptor activated by prokineticins PROK1 and PROK2. PROKR1 signaling can activate MAPK, STAT, calcium, and other downstream signaling pathways involved in proliferation, migration, angiogenesis, survival, and inflammatory responses.

Typical modulation in cancer: Context-dependent but frequently tumor-promoting when the prokineticin pathway is activated. ↑ PROKR1 signaling can support proliferation, migration, angiogenesis, and tumor-associated signaling; inhibition may therefore be anticancer in PROKR1-dependent tumors.

Typical modulation in Alzheimer’s disease: No established universal direction.
Scientific Papers found: Click to Expand⟱
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Casp12↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PROKR1↑, 1,   PROKR2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Migration(tgid=13) ⓘ

PROK2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   Learn↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: PROKR1, Prokineticin Receptor 1; PKR1,GRP73
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1865  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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