5-AR Cancer Research Results

5-AR, 5α-reductase: Click to Expand ⟱
Source:
Type:

5α-Reductase (Steroid 5-Alpha Reductase; SRD5A) — NADPH-dependent steroid-converting enzyme family that catalyzes conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen receptor agonist. The principal human isoenzymes are SRD5A1, SRD5A2, and SRD5A3.

BPH relevance: ↑ 5α-reductase activity, particularly SRD5A2 in prostate tissue, increases conversion of testosterone to DHT and promotes androgen-dependent prostate growth. Inhibition of 5α-reductase lowers DHT, reduces prostate volume, improves lower urinary tract symptoms, and reduces risk of urinary retention and BPH-related surgery.

Typical modulation in cancer: Context-dependent but frequently tumor-supportive in prostate cancer through maintenance of intratumoral DHT and androgen receptor signaling. SRD5A1 and SRD5A3 may become relatively more important in advanced or castration-resistant prostate cancer, whereas SRD5A2 expression can decrease during progression.

Typical modulation in Alzheimer’s disease: No established core Alzheimer’s disease direction. 5α-reductase enzymes also participate in neurosteroid metabolism, but their role in AD is complex and not suitable for a universal ↑ or ↓ designation.
Scientific Papers found: Click to Expand⟱
8606- PumpSO,  Tamsu,    Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial
- Trial, BPH, NA
*Dose?, *toxicity↓, *eff↓, *IPSS↝, *other↝, *UFR?, *5-AR↓, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

UFR?, 1,  

Functional Outcomes(tgid=23) ⓘ

IPSS↝, 1,   toxicity↓, 1,  
Total Targets: 8

Scientific Paper Hit Count for: 5-AR, 5α-reductase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1872  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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