CK/CK-MB Cancer Research Results

CK/CK-MB, Creatine Kinase: Click to Expand ⟱
Source:
Type:

CK (Creatine Kinase; Total CK) — Enzyme present predominantly in skeletal muscle, cardiac muscle, and brain that catalyzes reversible phosphate transfer between creatine and ATP. Serum CK is commonly used as a clinical biomarker of muscle injury, myopathy, rhabdomyolysis, strenuous exercise, and other forms of tissue damage.

Typical modulation: ↑ CK generally indicates increased muscle-cell membrane damage or tissue injury. Interpretation depends on clinical context because CK can increase after exercise, trauma, seizures, intramuscular injections, statin-associated myopathy, inflammatory myopathies, and other conditions.

CK-MB (Creatine Kinase-MB Isoenzyme) — CK isoenzyme composed of one M and one B subunit and enriched in cardiac muscle. Serum CK-MB has historically been used as a biomarker of myocardial injury and acute myocardial infarction, although cardiac troponin assays are now generally more sensitive and specific.

Typical modulation: ↑ CK-MB may indicate myocardial injury, but elevations can also occur with skeletal-muscle injury, surgery, trauma, or other conditions. Interpretation should therefore consider troponin measurements and the clinical context.
Scientific Papers found: Click to Expand⟱
8619- MO,  doxoR,    Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells
- vitro+vivo, BC, MCF7
*Dose↝, *cardioP↑, *ROS↓, *lipid-P↓, *antiOx↑, *Inflam↓, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MPO↓, ChemoSen↑, *Dose↝, *AST↓, *CK/CK-MB↓, *SOD↑, Synergy↑, MDA↑, NO↑, GSH↓, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   MDA↑, 1,   ROS↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Synergy↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   lipid-P↓, 1,   MPO↓, 1,   ROS↓, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,   CK/CK-MB↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: CK/CK-MB, Creatine Kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1873  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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