RASSF1A Cancer Research Results

RASSF1A, Ras Association Domain Family Member 1, Isoform A: Click to Expand ⟱
Source:
Type:

RASSF1A (Ras Association Domain Family Member 1, Isoform A) — Tumor-suppressive isoform of the RASSF1 gene involved in regulation of apoptosis, cell-cycle progression, microtubule stability, mitotic control, Hippo/MST signaling, and genomic stability. RASSF1A is one of the most frequently epigenetically silenced tumor suppressors in human cancer.

Typical modulation in cancer: ↓ RASSF1A expression or function is generally tumor-promoting. Loss of RASSF1A, commonly through promoter hypermethylation, is associated with increased proliferation, impaired apoptosis, chromosomal instability, invasion, metastasis, and poorer prognosis in many cancer types. Restoration or increased expression of RASSF1A is generally considered anticancer.
Scientific Papers found: Click to Expand⟱
8639- MBZ,    Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2 - in-vitro, AML, K562
ENOX2↓, MMP2↓, TumCI↓, RASSF1A↑, WFDC10A↑, METTL7A↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ENOX2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

METTL7A↑, 1,   RASSF1A↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

WFDC10A↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RASSF1A, Ras Association Domain Family Member 1, Isoform A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1874  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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