WFDC10A Cancer Research Results

WFDC10A, WAP10, WAP Four-Disulfide Core Domain 10A: Click to Expand ⟱
Source:
Type:

WFDC10A (WAP Four-Disulfide Core Domain 10A; WAP10) — Secreted/extracellular WAP-domain protein with predicted serine-type endopeptidase inhibitor activity. WFDC10A is associated with innate immune and antibacterial humoral responses and may regulate extracellular protease activity.

Typical modulation in cancer: Emerging and context-dependent. WFDC10A has been proposed as a tumor-suppressor-associated gene in recent cancer studies. In MDA-MB-231 breast cancer cells, mebendazole markedly increased WFDC10A expression, suggesting that ↑ WFDC10A may accompany an anticancer transcriptional response. However, the cancer literature remains limited, so a universal direction should not yet be assigned.
Scientific Papers found: Click to Expand⟱
8639- MBZ,    Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2 - in-vitro, AML, K562
ENOX2↓, MMP2↓, TumCI↓, RASSF1A↑, WFDC10A↑, METTL7A↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ENOX2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

METTL7A↑, 1,   RASSF1A↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

WFDC10A↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: WFDC10A, WAP10, WAP Four-Disulfide Core Domain 10A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1877  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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