mRET Cancer Research Results

mRET, mitochondrial Reverse Electron Transport: Click to Expand ⟱
Source:
Type:

Reverse Electron Transport (RET) — Mitochondrial electron-transport process in which electrons flow in the reverse direction from a highly reduced coenzyme Q (ubiquinol; QH2) pool through respiratory Complex I toward NAD+, rather than through the normal forward electron-transfer pathway. RET is favored by a high mitochondrial membrane potential and strongly reduced CoQ pool and can generate substantial mitochondrial superoxide/ROS at Complex I.

Typical modulation in cancer: Context-dependent. Increased RET can elevate mitochondrial ROS and promote oxidative stress, signaling, or cell death, but tumor cells may also exploit RET-derived ROS as signaling molecules under selected metabolic conditions. A universal anticancer direction should therefore not be assigned.

Typical mechanistic relationship: High mitochondrial membrane potential + highly reduced CoQ pool → RET ↑ → Complex I superoxide / mtROS ↑.
Scientific Papers found: Click to Expand⟱
8658- MLT,    Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport
- vitro+vivo, SCC, CAL27 - in-vitro, Tong, SCC9
ROS?, ETC↓, mRET↑, MMP↑, CoQ10↝, compI↑, compII↑, other↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CoQ10↝, 1,   ROS?, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   ETC↓, 1,   mRET↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: mRET, mitochondrial Reverse Electron Transport
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1882  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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