compV Cancer Research Results

compV, Mitochondrial Complex V (ATP Synthase; F1F0-ATP Synthase): Click to Expand ⟱
Source:
Type:

Mitochondrial Complex V (ATP Synthase; F1F0-ATP Synthase) — Final oxidative-phosphorylation complex of the mitochondrial inner membrane. Complex V uses the proton-motive force generated by respiratory-chain Complexes I, III, and IV to drive phosphorylation of ADP to ATP. It consists of a membrane-embedded F0 proton channel coupled to the catalytic F1 ATP-synthase domain.

Typical modulation in cancer: Context-dependent. ↑ Complex V activity can support ATP production and survival in tumors dependent on oxidative phosphorylation, while inhibition of ATP synthase can cause ATP depletion, mitochondrial dysfunction, metabolic stress, ROS changes, and cancer-cell death. Some tumors exhibit altered expression or activity of ATP-synthase subunits as part of metabolic reprogramming.

Typical modulation in Alzheimer’s disease: ↓ Complex V activity or expression can contribute to impaired mitochondrial ATP production, energetic failure, synaptic dysfunction, and neuronal vulnerability. ATP-synthase dysfunction and oxidative modification of its subunits have been reported in neurodegenerative disease.

Typical mechanistic relationship: Proton gradient / mitochondrial membrane potential → proton flow through F0 → rotation of ATP synthase → ADP + Pi → ATP.
Scientific Papers found: Click to Expand⟱
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compV↓, 1,   MFN2↓, 1,   mtDam↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

OCT4↓, 1,   SOX2↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3A↑, 1,   LC3B↑, 1,   MitoP↑, 1,   PARK2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   Nanog↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Zeb1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: compV, Mitochondrial Complex V (ATP Synthase; F1F0-ATP Synthase)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1886  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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