HAGH/GLO2 Cancer Research Results

HAGH/GLO2, Glyoxalase II, Hydroxyacylglutathione Hydrolase: Click to Expand ⟱
Source:
Type:

HAGH (Hydroxyacylglutathione Hydrolase; Glyoxalase II, GLO2) — Second enzyme of the glyoxalase pathway. HAGH/GLO2 hydrolyzes S-D-lactoylglutathione to D-lactate and regenerates reduced glutathione (GSH), thereby completing detoxification of the reactive glycolytic by-product methylglyoxal. Cytosolic and mitochondrial isoforms are present in human cells.

Typical modulation in cancer: Context-dependent. GLO2 participates in methylglyoxal detoxification and glutathione recycling, but its cancer role is less uniform than GLO1. Increased GLO2 has been associated with proliferation and treatment resistance in some cancer models, whereas mitochondrial GLO2 can also participate in pro-apoptotic signaling, including interaction with BAX. Therefore, no universal cancer direction should be assigned.

Typical modulation in Alzheimer’s disease: Potentially protective through methylglyoxal detoxification, glutathione regeneration, mitochondrial protection, and reduction of dicarbonyl/oxidative stress, but a consistent AD-specific disease direction is not established.

Typical mechanistic relationship: Methylglyoxal + GSH → GLO1 → S-D-lactoylglutathione → GLO2/HAGH → D-lactate + regenerated GSH.
Scientific Papers found: Click to Expand⟱
8740- MGO,    Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation
- in-vitro, Liver, HepG2
GLO-I↓, HAGH/GLO2↓, RAGE↑, AGEs↑, Hypoxia↑, ROS↑, GlucoseCon↑, GLUT1↑, HK2↑, PFK1↑, LDH↑, lactateProd↑, Glycolysis↑, Hif1a↑, Warburg↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GLO-I↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   HAGH/GLO2↓, 1,   HK2↑, 1,   lactateProd↑, 1,   PFK1↑, 1,   Warburg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,   Hypoxia↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

RAGE↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,   RAGE↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HAGH/GLO2, Glyoxalase II, Hydroxyacylglutathione Hydrolase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1890  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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