Glycine Cancer Research Results

Glycine, Glycine: Click to Expand ⟱
Source:
Type:

Glycine (Gly) — Nonessential amino acid involved in protein synthesis, one-carbon metabolism, nucleotide synthesis, glutathione production, heme synthesis, and mitochondrial metabolism. Glycine also functions as an inhibitory neurotransmitter and as a co-agonist at NMDA receptors.

Typical modulation in cancer: Context-dependent. Rapidly proliferating cancer cells may increase glycine uptake and utilization to support purine synthesis, one-carbon metabolism, glutathione production, and biomass generation. Increased glycine metabolism can therefore support proliferation in some tumors, although glycine supplementation may have different effects depending on tumor type and metabolic context.

Typical mechanistic relationships: Glycine → serine/glycine one-carbon metabolism → nucleotide synthesis; glycine + glutamate + cysteine → glutathione synthesis; glycine → NMDA receptor co-agonism.

b>Recommended group: Core Metabolism/Glycolysis (tgid=4).
Scientific Papers found: Click to Expand⟱
8846- DIM,  ORM,    Diindolylmethane Promotes Metabolic Crisis and Enhances the Efficacy of Centchroman in Breast Cancer: A 1H NMR-Based Approach
- vitro+vivo, BC, NA
AntiCan↑, EPR↑, Synergy↑, TumCG↓, Glycolysis↓, PKM2↓, GLUT1↓, Hif1a↓, eff↑, Glycine↓, Alanine↓, toxicity↓, Dose↝, TumW↓, Ki-67↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

Alanine↓, 1,   Glycine↓, 1,   Glycolysis↓, 1,   PKM2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   GLUT1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   toxicity↓, 1,   TumW↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Glycine, Glycine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1898  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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