Pyrim Cancer Research Results

Pyrim, Pyrimidine: Click to Expand ⟱
Source:
Type:

Pyrimidine / Pyrimidine Metabolism — Metabolic pathway responsible for synthesis, salvage, and degradation of pyrimidine nucleotides including uracil, cytosine, and thymine derivatives. Pyrimidine metabolism supplies UTP, CTP, dCTP, and dTTP required for RNA synthesis, DNA replication, membrane phospholipid synthesis, glycosylation, and cellular proliferation.

Typical modulation in cancer: ↑ pyrimidine synthesis and salvage are commonly associated with rapidly proliferating tumor cells because of increased demand for DNA and RNA precursors. Inhibition of pyrimidine metabolism can suppress proliferation, induce replication stress, cause DNA damage, and enhance sensitivity to anticancer therapies.

Typical mechanistic relationships: De novo pyrimidine synthesis → UMP → UDP/UTP → CTP and dTMP/dTTP → RNA/DNA synthesis. Key pathway enzymes include CAD, DHODH, UMPS, TYMS, and related salvage enzymes.
Scientific Papers found: Click to Expand⟱
8848- DIM,  5-FU,    3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer
- vitro+vivo, CRC, DLD1 - in-vitro, CRC, HCT116
TumCP↓, Pyrim↓, ChemoSen↑, TumVol↓, TumW↓, ROS↑, TumCCA↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Pyrim↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Pyrim, Pyrimidine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1900  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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