LIMK2 Cancer Research Results

LIMK2, LIM Domain Kinase 2: Click to Expand ⟱
Source:
Type:

LIMK2 (LIM Domain Kinase 2) — Serine/threonine kinase that regulates actin cytoskeleton organization, cell morphology, migration, invasion, and mitosis. LIMK2 phosphorylates cofilin proteins, thereby inhibiting their actin-depolymerizing activity and promoting stabilization/reorganization of actin filaments.

Typical modulation in cancer: Frequently ↑ or hyperactivated and generally associated with increased migration, invasion, cytoskeletal remodeling, metastatic potential, and in some cancers proliferation or therapy resistance. LIMK2 inhibition can reduce motility and invasive behavior, although effects are tumor-context dependent.

Typical mechanistic relationship: RhoA / ROCK → LIMK2 activation → cofilin phosphorylation ↑ → cofilin activity ↓ → actin filament stabilization/remodeling ↑ → migration and invasion ↑.

Additional functions: LIMK2 also participates in spindle formation, cytokinesis, cell-cycle regulation, and stress-response signaling.
Scientific Papers found: Click to Expand⟱
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   LIMK2↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   hyperG↝, 1,   NRF2↑, 1,   RNS↓, 1,   SOD1↑, 1,  

Cell Death(tgid=5) ⓘ

cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   iNOS↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

NGF↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   antiCG↑, 1,   AntiDiabetic↑, 1,   cognitive↑, 1,   neuroP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: LIMK2, LIM Domain Kinase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1904  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page