TIRAP Cancer Research Results

TIRAP, toll/interleukin 1 receptor domain-containing adaptor protein: Click to Expand ⟱
Source:
Type:

TIRAP (TIR Domain Containing Adaptor Protein) — Toll/interleukin-1 receptor (TIR)-domain adaptor protein that links activated Toll-like receptors, particularly TLR2 and TLR4, to MyD88-dependent innate immune signaling. TIRAP facilitates recruitment of MyD88 and subsequent activation of IRAK4, IRAK1, TRAF6, NF-kB, and MAPK pathways.

Typical modulation in cancer: Context-dependent. Increased TIRAP-dependent signaling can promote chronic inflammation, NF-kB activation, cytokine production, tumor-cell survival, and tumor-promoting inflammatory responses in selected cancers. In other settings, TLR/TIRAP activation can enhance antitumor immune activity.

Typical modulation in Alzheimer’s disease: Potentially ↑ in inflammatory contexts. TIRAP participates in TLR2/TLR4-mediated innate immune and microglial signaling and may contribute to neuroinflammatory responses associated with amyloid and other danger-associated signals.

Typical mechanistic relationship: TLR2/TLR4 activation → TIRAP recruitment → MyD88 → IRAK4 → IRAK1 → TRAF6 → TAK1 → NF-kB/MAPK activation → inflammatory cytokine expression ↑.
Scientific Papers found: Click to Expand⟱
9015- Phyco,    Phycocyanin Exerts Anti-Proliferative Effects through Down-Regulating TIRAP/NF-κB Activity in Human Non-Small Cell Lung Cancer Cells
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Lung, LTEP-a2
Apoptosis↑, TumCG↓, TIRAP↓, NF-kB↓, p‑IKKα↓, p‑p65↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑IKKα↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,   p‑p65↓, 1,   TIRAP↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TIRAP, toll/interleukin 1 receptor domain-containing adaptor protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1913  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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