GNAI1 Cancer Research Results

GNAI1, Gαi1, G-alpha-i1, G Protein Subunit Alpha I1: Click to Expand ⟱
Source:
Type:

GNAI1 (G Protein Subunit Alpha I1) — Gene encoding the heterotrimeric G-protein alpha-i1 subunit (Gαi1), a member of the inhibitory Gi/o family of G proteins. GNAI1 transduces signals from multiple G-protein-coupled receptors and typically inhibits adenylyl cyclase, resulting in reduced intracellular cAMP and altered downstream PKA, MAPK, PI3K/AKT, ion-channel, and Gβγ-dependent signaling.

Typical modulation in cancer: Context-dependent. Altered GNAI1 expression or signaling can influence proliferation, migration, invasion, survival, and response to GPCR-mediated signals. Depending on tumor type and receptor context, GNAI1 may have either tumor-promoting or tumor-suppressive effects, so a universal ↑ or ↓ cancer direction should not be assigned.

Typical mechanistic relationship: Gi-coupled GPCR activation → GNAI1/Gαi1 activation → adenylyl cyclase inhibition → cAMP ↓ → PKA signaling ↓, with additional signaling through Gβγ, PI3K/AKT, MAPK, and ion-channel pathways.
Scientific Papers found: Click to Expand⟱
9045- PatchO,    Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex
- vitro+vivo, NSCLC, H1299 - in-vitro, Lung, A549
TumAuto↑, toxicity↓, GNAI1↓, ERK↓, JAK2↓, STAT3↓, mTOR↓, eff↝, TumVol↓, toxicity↓, BioAv↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   GNAI1↓, 1,   JAK2↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 2,   TumVol↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GNAI1, Gαi1, G-alpha-i1, G Protein Subunit Alpha I1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1916  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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