Lcn2 Cancer Research Results

Lcn2, NGAL, 24p3, Lipocalin 2; Neutrophil Gelatinase-Associated Lipocalin: Click to Expand ⟱
Source:
Type:

LCN2 (Lipocalin 2; Neutrophil Gelatinase-Associated Lipocalin, NGAL) — Secreted lipocalin-family protein involved in innate immunity, iron homeostasis, inflammatory signaling, tissue injury, and cellular stress responses. LCN2 can bind iron-containing bacterial siderophores and restrict microbial iron acquisition.

Typical modulation in cancer: Context-dependent but frequently ↑ and tumor-promoting. Elevated LCN2 has been associated in multiple cancers with proliferation, migration, invasion, metastatic behavior, inflammatory tumor microenvironment, treatment resistance, and immune evasion. However, tumor-suppressive effects have also been reported in selected tumor types and contexts.

Typical modulation in Alzheimer’s disease / neuroinflammation: Frequently ↑ in inflammatory and reactive glial states. LCN2 can participate in astrocyte and microglial activation, iron dysregulation, inflammatory signaling, and neuronal stress, making it relevant to neurodegenerative and neuroinflammatory conditions.

Typical mechanistic relationships: Inflammatory / cellular stress → LCN2 ↑ → iron sequestration and immune signaling modulation → altered macrophage, neutrophil, glial, and tumor-cell responses. In cancer, LCN2 can also influence migration, invasion, metabolic adaptation, and immune-cell recruitment.

Clinical biomarker relevance: Circulating and urinary LCN2/NGAL are established biomarkers of acute kidney injury and can also reflect inflammatory or tissue-injury states.
Scientific Papers found: Click to Expand⟱
9070- L-THE,    Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses
- in-vivo, Nor, NA
*BrainVol↑, *NPAS4↑, *Lcn2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

Lcn2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BrainVol↑, 1,   NPAS4↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: Lcn2, NGAL, 24p3, Lipocalin 2; Neutrophil Gelatinase-Associated Lipocalin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1918  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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