NIK Cancer Research Results

NIK, MAP3K14, Mitogen-Activated Protein Kinase Kinase Kinase 14; NF-kB-Inducing Kinase: Click to Expand ⟱
Source:
Type:

MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14; NF-kB-Inducing Kinase, NIK) — Serine/threonine kinase that functions as a central upstream regulator of the non-canonical NF-kB signaling pathway. NIK activates IKKα, promoting processing of NF-kB2/p100 to p52 and formation of RELB:p52 transcriptional complexes.

Typical modulation in cancer: Frequently ↑ or aberrantly stabilized in selected cancers and generally tumor-promoting. Increased NIK activity can support survival, proliferation, inflammatory signaling, immune-cell interactions, and therapy resistance through persistent non-canonical NF-kB activation.

Typical mechanistic relationship: Receptor signaling → NIK/MAP3K14 stabilization ↑ → IKKα activation → NF-kB2/p100 processing to p52 ↑ → RELB:p52 nuclear translocation ↑ → non-canonical NF-kB target-gene transcription ↑.
Scientific Papers found: Click to Expand⟱
9079- MGF,    Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
- in-vivo, Melanoma, NA
TumMeta↓, TumCG↓, NF-kB↓, IKKα↓, MMPs↓, Casp3↑, PARP1↑, PUMA↑, P53↑, survivin↓, Bcl-xL↓, NIK↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Bcl-xL↓, 1,   Casp3↑, 1,   PUMA↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

IKKα↓, 1,   NIK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NIK, MAP3K14, Mitogen-Activated Protein Kinase Kinase Kinase 14; NF-kB-Inducing Kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1919  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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