PGF Cancer Research Results

PGF, PlGF, Placental Growth Factor: Click to Expand ⟱
Source:
Type:

PGF (Placental Growth Factor; PlGF) — Secreted member of the vascular endothelial growth factor (VEGF) family that promotes angiogenesis, endothelial-cell proliferation and migration, inflammatory-cell recruitment, and vascular remodeling. PGF signals primarily through FLT1/VEGFR1 and can also interact functionally with VEGF signaling pathways.

Typical modulation in cancer: Frequently ↑ and generally unfavorable. Increased PGF/PlGF signaling can promote tumor angiogenesis, endothelial-cell migration, stromal and myeloid-cell recruitment, tumor growth, invasion, metastasis, and resistance to anti-angiogenic therapy in selected cancers.

Typical mechanistic relationship: PGF/PlGF → FLT1/VEGFR1 activation → endothelial and myeloid-cell signaling → migration, angiogenesis, inflammation, and tumor vascularization ↑.

Hypoxia relevance: PGF expression can increase in hypoxic and inflammatory tissues and contributes to pathological angiogenesis and vascular remodeling.
Scientific Papers found: Click to Expand⟱
9081- MGF,    Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma
- in-vitro, Melanoma, NA
Inflam↓, lipid-P↓, NF-kB↓, IL6↓, TNF-α↓, IFN-γ↓, VEGF↓, uPA↓, MCP1/CCL2↓, PGF↓, angioG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↓, 1,  

Migration(tgid=13) ⓘ

PGF↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PGF, PlGF, Placental Growth Factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1921  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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