CD40 Cancer Research Results

CD40, TNFRSF5,: Click to Expand ⟱
Source: CD40 Molecule
Type:

CD40 (CD40 Molecule; TNFRSF5) — Cell-surface member of the tumor necrosis factor receptor superfamily that functions as an immune costimulatory receptor. CD40 is expressed on B cells, dendritic cells, macrophages, endothelial cells, and various malignant cells and is activated primarily by CD40 ligand (CD40L/CD154).

Typical modulation in cancer: Context-dependent. Activation of CD40 on antigen-presenting cells can enhance dendritic-cell maturation, antigen presentation, T-cell priming, macrophage activation, and antitumor immunity. Conversely, CD40 signaling in some tumor cells can promote survival, proliferation, inflammatory signaling, or resistance. Agonistic CD40 antibodies are under investigation as cancer immunotherapies.

Typical modulation in Alzheimer’s disease / neuroinflammation: Often associated with inflammatory activation. CD40-CD40L signaling can promote microglial and immune-cell activation, cytokine production, and neuroinflammatory responses.

Typical mechanistic relationship: CD40L/CD154 → CD40 → TRAF proteins → canonical/non-canonical NF-kB, MAPK and PI3K/AKT signaling → immune-cell activation, antigen presentation and inflammatory gene expression.
Scientific Papers found: Click to Expand⟱
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compIV↓, 1,   mtDam↑, 1,   SDH↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT1↓, 1,  

Migration(tgid=13) ⓘ

EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 1,   ROS⇅, 1,   SOD↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD40↓, 1,   IL10↓, 1,   Inflam↓, 1,   IP-10/CXCL-10↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   eff↑, 3,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   hepatoP↑, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,  
Total Targets: 27

Scientific Paper Hit Count for: CD40, TNFRSF5,
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1924  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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