DEFB1 Cancer Research Results

DEFB1, hBD-1, Defensin Beta 1; Human Beta-Defensin 1,: Click to Expand ⟱

Source:

Type:

DEFB1 (Defensin Beta 1; Human Beta-Defensin 1, hBD-1) — Small cationic antimicrobial peptide expressed primarily by epithelial tissues and involved in innate mucosal defense. DEFB1 contributes to resistance against microbial colonization and can also influence inflammatory signaling, chemotaxis, epithelial barrier function, and immune-cell responses.

Typical modulation in cancer: Context-dependent, but DEFB1 expression is reduced in several epithelial cancers and may have tumor-suppressive properties in selected tissues. Experimental restoration of DEFB1 has been associated with reduced tumor-cell survival or growth in some models, although effects are cancer-type dependent.

Typical modulation in Alzheimer’s disease / neuroinflammation: Limited direct evidence. DEFB1 is primarily an epithelial innate-immune peptide rather than a core Alzheimer’s disease target.

Typical mechanistic relationships: Microbial or inflammatory signals → DEFB1 expression/release → antimicrobial activity and innate immune defense ↑. DEFB1 can also influence chemotaxis and immune signaling, including interactions with CCR6-associated pathways.

Scientific Papers found: Click to Expand⟱

9176-

BITC,

Nast,

A 14-Day Double-Blind, Randomized, Controlled Crossover Intervention Study with Anti-Bacterial Benzyl Isothiocyanate from Nasturtium (Tropaeolum majus) on Human Gut Microbiome and Host Defense

Study,

UTI,

*AntiBio↑, *Dose?, *DEFB1↑, *GutMicro∅, *eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Immune & Inflammatory Signaling(tgid=16) ⓘ

DEFB1↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1, eff↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, GutMicro∅, 1,
Total Targets: 5

Scientific Paper Hit Count for: DEFB1, hBD-1, Defensin Beta 1; Human Beta-Defensin 1,

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells