PFKFB4 Cancer Research Results

PFKFB4, (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4: Click to Expand ⟱
Source:
Type:

PFKFB4 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4) — Bifunctional metabolic enzyme that regulates intracellular fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of phosphofructokinase-1 (PFK1). PFKFB4 helps coordinate glycolytic flux, pentose-phosphate pathway activity, redox balance, and metabolic adaptation to cellular stress.

Typical modulation in cancer: Frequently ↑ and generally unfavorable. Elevated PFKFB4 supports tumor-cell survival, metabolic flexibility, NADPH/redox homeostasis, proliferation, hypoxia adaptation, and resistance to oxidative and nutrient stress. PFKFB4 inhibition can impair tumor growth in several experimental cancer models.

Typical mechanistic relationship: PFKFB4 activity → F2,6BP regulation → PFK1/glycolysis modulation and redistribution of glucose-derived carbon between glycolysis and the pentose-phosphate pathway → NADPH and biosynthetic support ↑ → tumor-cell survival and proliferation ↑.

Hypoxia relevance: PFKFB4 is often induced in hypoxic or metabolically stressed tumor cells and can contribute to HIF-associated metabolic adaptation.
Scientific Papers found: Click to Expand⟱
9242- ISO, IH,    Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF- κ B Pathways
- vitro+vivo, Melanoma, B16-BL6
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, NF-kB↓, PFKFB4?, BAX↑, Casp3↑, Bcl-2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PFKFB4?, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PFKFB4, (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1931  State#:%  Dir#:%
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