MMP14 Cancer Research Results

MMP14, MT1-MMP, Matrix Metallopeptidase 14: Click to Expand ⟱
Source:
Type:

MMP14 (Matrix Metallopeptidase 14; MT1-MMP) — Membrane-anchored zinc-dependent matrix metalloproteinase that mediates pericellular extracellular-matrix degradation. MMP14 cleaves fibrillar collagens and other ECM components, activates pro-MMP2, and is a major regulator of invadopodia, tissue remodeling, cell migration, and invasion.

Typical modulation in cancer: ↑ MMP14 is generally tumor-promoting and is frequently associated with increased extracellular-matrix degradation, invasion, migration, angiogenesis, EMT, metastasis, treatment resistance, and poor prognosis. MMP14 inhibition or downregulation is therefore generally considered anticancer.

Typical modulation in Alzheimer’s disease: No consistent Alzheimer’s disease-specific direction is established. MMP14 may influence extracellular-matrix remodeling and neuroinflammatory processes, but it is primarily a cancer/invasion target.
Scientific Papers found: Click to Expand⟱
6255- Cyste,    Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity
- in-vitro, GBM, NA
MMPs↓, MMP2↓, MMP9↓, MMP14↓, TumCI↓, TumCMig↓, Dose↓,
8571- Matr,    Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling
- in-vitro, PC, Capan1
Dose↝, TumCP↓, Wnt↓, β-catenin/ZEB1↓, MMP14↓,
8716- MeJa,    Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14
- in-vitro, GC, SGC-7901 - in-vitro, GC, MKN-28
TumCMig↓, TumCI↓, angioG↓, MMP14↓, VEGF↓, Sp1/3/4↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

MMP14↓, 3,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   Dose↝, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MMP14, MT1-MMP, Matrix Metallopeptidase 14
1 Cysteamine
1 Matrine
1 Methyl Jasmonate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:200  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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