NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
2434- 2DG,    Inhibition of Key Glycolytic Enzyme Hexokinase 2 Ameliorates Psoriasiform Inflammation in vitro and in vivo
- in-vitro, PSA, NA - in-vivo, PSA, NA
HK2↓, NF-kB↓, NLRP3↓,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
5470- AF,    Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin
- Review, Var, NA
TrxR↓, other↝, IL6↑, IL8↑, NK cell⇅, COX2/PTGS2↓, NOS2↓, NRF2↑, Prx↑, Half-Life↑, Dose↝, ROS↑, NF-kB↓,
5463- AF,    Will Auranofin Become a Golden New Treatment Against COVID-19?
- Review, Covid, NA
IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, Synergy↑, eff↑, MMP↓, AIF↑, toxicity↓,
1334- AG,    Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer
- Review, NSCLC, NA
TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
1594- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓, antiOx↑, TumCP↓,
5147- AgNPs,    Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,
4428- AgNPs,    p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells
- in-vitro, AML, Jurkat
toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
334- AgNPs,    Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53
- in-vitro, Colon, HCT116
Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, Synergy↑, Catalase↑, other↑,
402- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7
P53↑, iNOS↑, NF-kB↑, Bcl-2↓, miR-125b↓, ROS↑, SOD↑,
400- AgNPs,  MF,    Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field
- in-vitro, Laryn, HEp2
TumCP↓, Casp3↑, P53↑, Beclin-1/ATG6↑, TumAuto↑, GSR↑, ROS↑, MDA↑, ROS↑, SIRT1↑, Ca+2↑, Endon↑, DNAdam↑, Apoptosis↑, NF-kB↓,
379- AgNPs,    Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
- in-vivo, Lung, H1299
NF-kB↓, Bcl-2↓, Casp3↑, survivin↑, TumCG↓,
389- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
5340- Ajoene,    Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB
- in-vitro, AML, NA
Apoptosis↑, selectivity↑, H2O2↑, NF-kB↑,
252- Ajoene,    Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB
- in-vitro, AML, HL-60
H2O2↑, NF-kB↑, ROS↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
544- AL,    Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations
- Review, Var, NA
Risk↓, ChemoSideEff↓, TumCG↓, NF-kB⇅,
253- AL,    Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α
- in-vitro, BC, MDA-MB-231
TumCMig↓, ERK↓, VCAM-1↓, NF-kB↓,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
2668- AL,  Rad,    Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF-κB signaling pathway
- in-vitro, CRC, HCT116
RadioS↑, NF-kB↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1/CCL2↓, *NF-kB↓, IKKα↓,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3450- ALA,    α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells
- in-vitro, GC, AGS
*IL8↓, *MAPK↓, *JAK↓, *STAT↓, *NF-kB↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
298- ALA,  Rad,    Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1
- in-vitro, BC, MDA-MB-231
Apoptosis↑, P53↑, p38↑, NF-kB↑, TumCCA↑,
272- ALA,    Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function
- in-vitro, NA, HUVECs
NF-kB↓,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

Showing Research Papers: 1 to 50 of 1068
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1068

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 22,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 9,   Catalase↑, 8,   Copper↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 8,   GPx1↓, 2,   GPx4↓, 9,   GPx4↑, 1,   GSH↓, 46,   GSH↑, 11,   GSH/GSSG↓, 2,   GSR↓, 4,   GSR↑, 4,   ox-GSSG↑, 1,   GSTs↓, 5,   GSTs↑, 5,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 9,   HO-1↓, 13,   HO-1↑, 28,   HO-1↝, 1,   HO-2↓, 1,   Iron↑, 4,   i-Iron↑, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 11,   lipid-P↑, 15,   MDA↓, 5,   MDA↑, 7,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 7,   NRF2↓, 31,   NRF2↑, 39,   NRF2↝, 4,   NRF2∅, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 52,   ROS↑, 323,   ROS⇅, 10,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 3,   mt-ROS↑, 6,   SOD?, 1,   SOD↓, 13,   SOD↑, 14,   SOD1↓, 1,   SOD1↑, 2,   SOD2↓, 7,   SOD2↑, 2,   TAC↓, 2,   TBARS↑, 1,   Thiols↓, 4,   i-Thiols↓, 1,   TKT↝, 1,   Trx↓, 3,   Trx1↑, 1,   TrxR↓, 12,   TrxR1↓, 4,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   IronCh↑, 3,   IronCh∅, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 8,   CDC2↑, 1,   CDC25↓, 11,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   CS↓, 1,   EGF↓, 6,   ETC↓, 3,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 4,   mitResp↑, 2,   MKK7↓, 1,   MKP5↑, 1,   mtDam↑, 28,   OCR↓, 7,   OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PDH↑, 2,   PDH↝, 1,   SDH↑, 1,   SIRT3↓, 3,   SIRT3↑, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 11,   AApath↓, 1,   ACC↓, 1,   ACC↑, 4,   Acetyl-CoA↓, 1,   ACLY↓, 2,   ACSL4↑, 1,   ALAT↓, 7,   ALAT↝, 1,   ALDOA↓, 1,   AMP↓, 2,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 33,   p‑AMPK↑, 2,   ANXA7↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 22,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   cAMP↓, 1,   CholSyn↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 9,   FASN↑, 1,   FFA/NEFA↓, 1,   G6PD↓, 3,   GAPDH↓, 2,   GLS↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 13,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 43,   GSK‐3β↓, 20,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 8,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 28,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 15,   lactateProd↑, 1,   LDHA↓, 14,   LDL↓, 3,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 4,   O-Glc↓, 1,   PA↑, 1,   PCK1↓, 2,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 9,   PDK3↑, 1,   PFK↓, 5,   PFK1↓, 3,   PKM2↓, 19,   PLA2↓, 1,   Pyruv↓, 1,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 11,   SIRT1↑, 16,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   SSAT↑, 1,   TCA↓, 3,   TS↓, 1,   Warburg↓, 12,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 9,   Apoptosis?, 6,   Apoptosis↓, 7,   Apoptosis↑, 315,   Apoptosis↝, 1,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 3,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 5,   BAD↑, 15,   Bak↓, 1,   Bak↑, 14,   BAX↓, 4,   BAX↑, 158,   BAX⇅, 2,   BAX↝, 3,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 47,   Bcl-2↓, 187,   Bcl-2↑, 6,   Bcl-2↝, 2,   Bcl-xL↓, 65,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 10,   cl‑BID↑, 1,   BIM↑, 9,   BNIP3↑, 5,   BOK↑, 1,   Casp↓, 3,   Casp↑, 47,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 2,   Casp1↓, 3,   Casp1↑, 3,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 2,   Casp12↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 187,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 36,   cl‑Casp3⇅, 1,   proCasp3↑, 3,   Casp6↑, 3,   Casp7↑, 19,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 55,   Casp8∅, 2,   cl‑Casp8↑, 8,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 117,   p‑Casp9↑, 1,   cl‑Casp9↑, 16,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 8,   Cyt‑c↓, 3,   Cyt‑c↑, 114,   Cyt‑c↝, 2,   mt-Cyt‑c↓, 1,   Diablo↑, 13,   DR5↑, 37,   Endon↑, 2,   FADD↑, 6,   Fap1↓, 1,   Fas↓, 5,   Fas↑, 26,   FasL↓, 3,   FasL↑, 10,   FasL⇅, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 14,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 26,   IAP2/BIRC3↓, 12,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 33,   iNOS↑, 3,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 34,   Mcl-1↑, 2,   MDM2↓, 15,   MDM2↑, 3,   p‑MDM2↓, 1,   MOMP↑, 3,   NAIP↓, 1,   Necroptosis↑, 4,   necrosis↑, 4,   NOXA↑, 5,   oncosis↑, 2,   p38↓, 13,   p38↑, 34,   p‑p38↓, 3,   p‑p38↑, 5,   p‑p38↝, 1,   Paraptosis↑, 2,   PUMA↓, 2,   PUMA↑, 7,   Pyro↑, 3,   RIP1↓, 2,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 89,   survivin↑, 1,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAIL↑, 8,   TRAIL⇅, 1,   TRAILR↑, 6,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 22,   TumCD∅, 1,   XIAP?, 1,   XIAP↓, 57,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 249,   Akt↑, 11,   Akt↝, 4,   p‑Akt↓, 57,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 3,   CaMKII ↓, 2,   CIP2A↓, 3,   CK2↓, 5,   cMET↓, 6,   p‑cMET↑, 1,   CREB↓, 5,   CREB2↓, 1,   cSrc↓, 4,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 66,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 5,   ERK↓, 89,   ERK↑, 9,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 2,   p‑ERK⇅, 1,   p‑ERK↝, 1,   FGFR1↓, 2,   FLT3↓, 1,   FOXD3↑, 2,   HCAR2↑, 2,   HER2/EBBR2↓, 20,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 4,   Hippo↑, 1,   HRAS↓, 2,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 3,   IKKα↓, 31,   IKKα↑, 4,   IKKα↝, 1,   p‑IKKα↓, 7,   IR↓, 1,   IκB↓, 6,   IκB↑, 4,   p‑IκB↓, 7,   p‑IκB↑, 2,   JAK↓, 14,   p‑JAK↓, 1,   JAK1↓, 7,   JAK1↑, 1,   JAK2↓, 19,   JNK↓, 17,   JNK↑, 33,   JNK↝, 2,   p‑JNK↓, 8,   p‑JNK↑, 4,   p‑JNK↝, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 69,   MAPK↑, 19,   MAPK↝, 3,   p‑MAPK↓, 2,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 110,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 11,   mTORC2↓, 4,   NRAS↓, 1,   p‑p42↓, 1,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 1,   P90RSK↓, 2,   PAK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFR-BB↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 186,   PI3K↑, 2,   PI3K↝, 4,   p‑PI3K↓, 10,   PI3K/Akt↓, 8,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   p‑PKA↓, 1,   PKCδ↓, 14,   p‑PKCδ↓, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 4,   PTEN↑, 38,   PTEN↝, 1,   p‑PTEN↓, 1,   Raf↓, 7,   p‑Raf↓, 1,   c-Raf↓, 1,   RAS?, 1,   RAS↓, 21,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   RTK-RAS↓, 1,   SHP1↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 26,   Sp1/3/4↑, 1,   Src↓, 5,   p‑Src↓, 1,   STAT↓, 13,   p‑STAT↓, 1,   STAT3↓, 126,   STAT3↑, 5,   STAT3↝, 1,   p‑STAT3↓, 19,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT4↑, 1,   STAT5↓, 3,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 5,   ATF3↓, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 12,   ATF4↝, 1,   CBP↓, 3,   cJun↓, 14,   cJun↑, 6,   p‑cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 61,   cMyc↑, 2,   p‑cMyc↑, 1,   CREBBP↓, 1,   DNMT1↓, 17,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 12,   DNMTs⇅, 1,   EZH2↓, 8,   FOXM1↓, 7,   FOXO↓, 2,   FOXO↑, 6,   FOXO1↓, 5,   FOXO1↑, 2,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↓, 1,   H3↓, 3,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 11,   HATs↑, 2,   HATs⇅, 1,   HDAC↓, 35,   HDAC⇅, 1,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC8↓, 6,   HES1↓, 2,   HOXB-AS1↓, 1,   IRF1↑, 1,   Matr↓, 1,   miR-107↑, 2,   miR-125b↓, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-155↓, 4,   miR-19b↓, 1,   miR-200b↑, 2,   miR-200c↑, 2,   miR-203↑, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-218↑, 1,   miR-224↓, 2,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-29b↑, 1,   miR-340↓, 2,   miR-34a↓, 2,   miR-34a↑, 8,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-448↑, 1,   miR-590-3p↑, 1,   MTA2↓, 2,   Myc↓, 11,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 11,   other↓, 8,   other↑, 5,   other↝, 12,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 3,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 9,   SOX4↓, 3,   SOX4↑, 1,   SOX9?, 1,   SOX9↑, 1,   SUZ12↓, 1,   TCF-4↓, 3,   TFAP2A↓, 1,   TLE1↓, 1,   tumCV?, 1,   tumCV↓, 71,   tumCV∅, 1,   YMcells↓, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 25,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 7,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 47,   GRP78/BiP↓, 2,   GRP78/BiP↑, 13,   HSF1↓, 2,   HSP27↓, 7,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 21,   HSPs↓, 2,   IRE1↑, 3,   NQO2↑, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome?, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 7,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 7,   ATG7↑, 2,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 21,   LC3s↑, 1,   LysoPr↑, 1,   p62↓, 8,   p62↑, 2,   p‑p62↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 62,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 3,   DNAdam↓, 4,   DNAdam↑, 69,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 18,   MGMT↓, 1,   p16↑, 7,   P53?, 3,   P53↓, 7,   P53↑, 150,   P53↝, 5,   p‑P53↓, 1,   p‑P53↑, 5,   p53 Wildtype↑, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 25,   PARP↝, 2,   cl‑PARP↑, 81,   cl‑PARP1↑, 2,   PCNA↓, 46,   RAD51↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 20,   TOP1↓, 17,   TOP2↓, 7,   TOP2↑, 2,   TP53↓, 2,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 8,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 16,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK2↓, 57,   CDK2↑, 3,   CDK4↓, 71,   CDK4↑, 1,   CDK4/6↓, 3,   CDK6↓, 22,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 2,   Chk2↓, 3,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 12,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 27,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 138,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   CycD3↓, 3,   cycE/CCNE↓, 28,   cycE/CCNE↑, 2,   cycE1↓, 1,   E2Fs↓, 7,   GADD45A↑, 2,   Ki-67↓, 36,   MAD↓, 1,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 9,   P21↑, 101,   P21↝, 2,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 44,   pRB↓, 3,   pRB↑, 2,   p‑pRB↓, 5,   RB1↓, 1,   RB1↑, 3,   p‑RB1↓, 6,   Securin↓, 2,   TumCCA?, 3,   TumCCA↓, 11,   TumCCA↑, 253,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 12,   ALDH1A1↓, 3,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD133↑, 1,   CD24↓, 3,   CD34↓, 3,   CEBPB↓, 1,   cFos↓, 16,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 67,   Diff↓, 1,   Diff↑, 4,   EIF4E↓, 2,   EP2↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 8,   HH↓, 13,   HMGCR↓, 1,   IGF-1?, 1,   IGF-1↓, 12,   IGF-2↓, 1,   IGFBP1↑, 1,   IGFBP3↑, 2,   Jun↓, 2,   p‑Jun↓, 1,   Ki-67↓, 36,   Let-7↓, 1,   Let-7↑, 7,   LRP6↓, 1,   mTORC1↓, 9,   Nanog↓, 10,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 30,   NOTCH↑, 1,   NOTCH1↓, 22,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH3↓, 4,   p300↓, 4,   PTCH1↓, 5,   SCF↓, 3,   Shh↓, 11,   Smo↓, 5,   STAT1↓, 3,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 123,   TumCG↑, 2,   TumCP?, 2,   TumCP↓, 219,   TumCP↑, 4,   Wnt?, 1,   Wnt↓, 80,   Wnt↑, 2,   Wnt/(β-catenin)↓, 7,   Wnt/(β-catenin)↑, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 32,   AP-1↑, 1,   AP-1↝, 2,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 1,   Ca+2↑, 33,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 2,   CCN2/CTGF↓, 3,   CD11b↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 2,   E-cadherin↓, 10,   E-cadherin↑, 60,   EFEMP↓, 1,   EMT↓, 113,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 27,   FAK↑, 2,   p‑FAK↓, 5,   p‑FAK↑, 1,   fascin↓, 2,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 3,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 6,   ITGB1↑, 1,   ITGB3↓, 3,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 4,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 4,   MET↓, 3,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 10,   MMP13↓, 5,   MMP16↓, 3,   MMP2↓, 143,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 21,   MMP9↓, 186,   MMP9↑, 4,   MMPs↓, 51,   MMPs↝, 1,   MTA1↓, 1,   MUC1-C↓, 1,   MUC4↓, 7,   N-cadherin↓, 34,   NCAM↑, 1,   NEDD9↓, 1,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↓, 1,   PAK1↓, 1,   PDGF↓, 10,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 6,   Rho↑, 1,   Rho↝, 1,   ROCK1↓, 5,   ROCK1↑, 2,   serineP↓, 1,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 14,   Smad1↑, 1,   Smad1↝, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 32,   Snail↑, 1,   SPARC↓, 1,   SPARC↑, 1,   STAC2↓, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 28,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 1,   TIMP1↓, 4,   TIMP1↑, 11,   TIMP2↓, 4,   TIMP2↑, 13,   TRIB3↑, 2,   TSP-1↑, 3,   TumCA↓, 5,   TumCI↓, 127,   TumCI↑, 2,   TumCMig↓, 118,   TumCMig↑, 2,   TumMeta↓, 107,   TumMeta↑, 10,   TumPF↓, 1,   Twist↓, 26,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 38,   uPAR↓, 6,   Vim↓, 49,   Vim↑, 1,   Zeb1↓, 15,   Zeb1↑, 1,   ZEB2↓, 1,   ZEB2↑, 2,   α-SMA↓, 3,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 85,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 152,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 9,   ECM/TCF↓, 1,   EGR1↑, 1,   Endoglin↑, 1,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 12,   Hif1a↓, 88,   Hif1a↝, 2,   LOX1↓, 2,   NO↓, 11,   NO↑, 4,   NO↝, 1,   PHDs↓, 1,   VCAM-1↓, 4,   VEGF↓, 186,   VEGF↑, 1,   VEGF↝, 2,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 21,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 11,   CLDN1↓, 3,   CLDN2↓, 1,   CTR1↑, 1,   CX43/GJA1↓, 1,   EPR↑, 4,   GLUT1↓, 19,   GLUT1↑, 1,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT4↓, 7,   MMP↓, 145,   MMP↑, 2,   MMP↝, 1,   MPT↑, 4,   NHE1↓, 2,   SLC12A5↝, 1,   TRPV1↑, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↓, 2,   CD4+↑, 5,   CD44↓, 19,   CD8+↑, 3,   COX1↓, 7,   COX1↑, 1,   COX2/PTGS2↓, 195,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCc↓, 2,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR3↓, 1,   CXCR4↓, 24,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 14,   FOXP3↓, 2,   FOXP3↑, 2,   GM-CSF↓, 2,   HCAR1↓, 1,   HCAR2↑, 2,   HLA↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 7,   ICAM-1↓, 17,   IFN-γ↓, 4,   IFN-γ↑, 4,   IL1↓, 12,   IL1↑, 1,   IL10↓, 7,   IL10↑, 4,   IL12↓, 5,   IL12↑, 2,   IL15↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 40,   IL1β↑, 1,   IL2↓, 7,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 4,   IL4↑, 2,   IL5↓, 1,   IL6↓, 91,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 21,   IL8↑, 2,   Imm↑, 16,   Imm↝, 3,   Inflam↓, 77,   Inflam↝, 1,   IRAK1↓, 2,   IRAK4↓, 1,   LRIG1↑, 1,   M1↓, 1,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 8,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 2,   mPGES-1↓, 1,   MyD88↓, 2,   MyD88↑, 1,   NF-kB?, 3,   NF-kB↓, 668,   NF-kB↑, 33,   NF-kB⇅, 1,   NF-kB↝, 7,   p‑NF-kB↓, 10,   p‑NF-kB↑, 4,   NK cell↑, 8,   NK cell⇅, 1,   NLRP3↓, 9,   NLRP3↑, 3,   NOD1↓, 1,   p50↓, 8,   p65↓, 28,   p65↑, 1,   p‑p65↓, 8,   p‑p65↑, 1,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 3,   PD-L1↓, 11,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 41,   PSA↓, 13,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 3,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 1,   TLR2↓, 2,   TLR4↓, 19,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 90,   TNF-α↑, 7,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRAF1↓, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   AChE↓, 1,   ADAM10?, 1,   ADAM10↓, 1,   BChE↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 28,   AR↝, 1,   AR-V7?, 1,   CYP17A1↓, 1,   CYP19?, 1,   CYP19↓, 2,   ER-α36↓, 3,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,   GR↑, 1,   PPARα↓, 3,   PPARα↑, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 11,   PPARγ↝, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 62,   BioAv↑, 67,   BioAv↝, 20,   BioEnh?, 1,   BioEnh↑, 6,   ChemoSen↓, 4,   ChemoSen↑, 227,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↓, 4,   CompStab↑, 4,   CompStab↝, 3,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 5,   Dose↓, 1,   Dose↑, 11,   Dose⇅, 2,   Dose↝, 63,   Dose∅, 11,   DrugR↓, 1,   eff↓, 41,   eff↑, 95,   eff↝, 11,   eff∅, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTP1/GSTπ↑, 1,   Half-Life↓, 20,   Half-Life↑, 4,   Half-Life↝, 17,   Half-Life∅, 1,   MDR1↓, 9,   MRP1/ABCC1↓, 5,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 22,   P-gp/ABCB1↝, 1,   P450↓, 7,   P450↝, 1,   RadioS↑, 84,   selectivity↑, 93,   selectivity∅, 1,   Synergy↑, 110,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 7,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 28,   AR↝, 1,   ascitic↓, 2,   AST↓, 5,   AST↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   CA125↓, 1,   CEA↓, 3,   CRP↓, 2,   CYFRA21-1↓, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 66,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 5,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 8,   Ferritin↓, 1,   FOXM1↓, 7,   HER2/EBBR2↓, 20,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 18,   IL6↓, 91,   IL6↑, 2,   IL6↝, 1,   IRes↓, 1,   KRAS↓, 1,   LDH↓, 13,   LDH↑, 4,   LDH↝, 3,   i-LDH↓, 1,   Myc↓, 11,   Myc↑, 1,   NOS2↓, 3,   NSE↓, 1,   PD-L1↓, 11,   PD-L1↑, 1,   PSA↓, 13,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   SUZ12↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 2,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 76,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 30,   cachexia↓, 3,   cardioP↑, 16,   CardioT↑, 1,   chemoP↑, 45,   chemoPv↑, 30,   chemoPv⇅, 1,   ChemoSideEff↓, 10,   cognitive?, 1,   cognitive↑, 5,   FTO↓, 1,   hepatoP↓, 1,   hepatoP↑, 14,   neuroP↓, 1,   neuroP↑, 18,   NP/CIPN↓, 1,   Obesity↓, 1,   OS?, 2,   OS↑, 17,   Pain↓, 1,   QoL↑, 7,   radioP↑, 8,   Remission↑, 2,   RenoP↑, 13,   Risk↓, 19,   toxicity↓, 22,   toxicity↑, 5,   toxicity↝, 10,   toxicity∅, 4,   TumVol↓, 36,   TumVol∅, 1,   TumW↓, 17,   TumW∅, 1,   Weight↓, 1,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 9,   GutMicro↝, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 1314

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↓, 8,   antiOx↑, 234,   ARE↑, 7,   ARE↝, 1,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 105,   DPPH↓, 1,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 66,   GPx1↑, 2,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 124,   GSR↓, 2,   GSR↑, 12,   GSSG↓, 2,   GSTs↓, 2,   GSTs↑, 31,   H2O2↓, 9,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 5,   HNE↓, 2,   HNE↑, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 108,   hyperG↓, 1,   Iron↓, 1,   Iron∅, 1,   Keap1↓, 4,   Keap1↑, 2,   Keap1↝, 1,   ox-Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 95,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 87,   MDA↑, 1,   MPO↓, 20,   MPO↑, 1,   NFE2L2↓, 1,   NOX↓, 3,   NOX4↓, 6,   NQO1↑, 22,   Nrf1↑, 5,   NRF2?, 1,   NRF2↓, 6,   NRF2↑, 168,   NRF2↝, 1,   ONOO↓, 1,   Prx↑, 2,   RNS↓, 6,   ROS?, 2,   ROS↓, 319,   ROS↑, 5,   ROS⇅, 1,   ROS∅, 4,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 2,   SOD↓, 2,   SOD↑, 138,   SOD1↑, 7,   SOD2↑, 5,   TAC↑, 19,   TBARS↓, 7,   Thiols↑, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 1,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 14,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↑, 3,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 1,   PGC-1α↓, 2,   PGC-1α↑, 7,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   12LOX↑, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 13,   5LO↝, 1,   ACC↓, 2,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 37,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 30,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 13,   Buty↑, 1,   cAMP↑, 3,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   glucose↓, 7,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 6,   GlutMet↑, 1,   Glycolysis↑, 2,   GSK‐3β↓, 21,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 13,   lipidLev↓, 4,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 10,   NADPH↑, 7,   PGC1A↑, 1,   PKM2↓, 2,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 28,   SIRT1↝, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 35,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 22,   BAX↑, 3,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 15,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   Casp↓, 2,   Casp1↓, 6,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 37,   Casp3↑, 1,   Casp3∅, 2,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 2,   Casp9↓, 13,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 8,   Cyt‑c↑, 1,   Cyt‑c∅, 3,   Fas↓, 2,   Ferroptosis↓, 5,   GSDMD↓, 1,   iNOS↓, 84,   iNOS↑, 4,   necrosis↓, 2,   p38↓, 12,   p38↑, 3,   p‑p38↓, 7,   Pyro?, 1,   Pyro↓, 2,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 16,   Akt↑, 20,   Akt↝, 2,   p‑Akt↓, 2,   p‑Akt↑, 7,   Akt2↓, 1,   CREB↓, 1,   CREB↑, 5,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 17,   ERK↑, 9,   p‑ERK↓, 5,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB?, 1,   IκB↓, 2,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 18,   JNK↑, 1,   p‑JNK↓, 7,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 47,   MAPK↑, 7,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 3,   MEK↓, 1,   p‑MKK4↑, 1,   mTOR↓, 3,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 15,   PI3K↑, 14,   PI3K↝, 1,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 4,   PP2A↑, 1,   PTEN↓, 3,   PTEN↑, 2,   Sp1/3/4↑, 1,   STAT↓, 5,   STAT3↓, 10,   STAT3↑, 4,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC↑, 1,   HDAC2↓, 2,   HDAC3↓, 1,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 7,   other↑, 6,   other↝, 14,   RUNX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 5,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   HSPs↝, 1,   PERK↓, 1,   UPR↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3B↑, 1,   LC3II↓, 2,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 4,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 12,   p16↓, 1,   P53↓, 7,   P53↝, 1,   PARP↓, 1,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 2,   P21↓, 3,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Choline↑, 1,   Diff↑, 2,   EP300↓, 1,   HH↓, 1,   IGF-1↑, 2,   Ki-67↓, 2,   MSCs↑, 1,   neuroG↑, 2,   p300↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 25,   AP-1↓, 11,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 5,   COL1↓, 2,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↑, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 2,   MMP13↓, 4,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 1,   MMP9↓, 16,   MMP9↑, 2,   MMPs↓, 5,   MMPs↑, 2,   MUC1↑, 2,   Na+↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 10,   TGF-β↑, 4,   TGF-β1↓, 2,   TGF-β1↑, 2,   TIMP1↓, 3,   TIMP1↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 3,   α-SMA↓, 8,   α-SMA↝, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   angioG↑, 4,   angioG↝, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 5,   ECM/TCF↑, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 7,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 57,   NO↑, 4,   TXA2↓, 1,   VCAM-1↓, 18,   VEGF↓, 9,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 2,   BBB↑, 40,   BBB↝, 4,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN3↑, 1,   CLDN4↑, 1,   GastroP↑, 5,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 5,   MMP↓, 2,   MMP↑, 24,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 4,   OCLN↝, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↓, 1,   ZO-1↑, 8,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 5,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 131,   COX2/PTGS2↑, 2,   Eos↓, 1,   FOXP3↑, 2,   HMGB1↓, 7,   ICAM-1↓, 17,   IFN-γ↓, 15,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 11,   IL10↓, 8,   IL10↑, 27,   IL12↓, 7,   IL13↓, 1,   IL17↓, 7,   IL18↓, 5,   IL1RL1/ST2↓, 1,   IL1β↓, 116,   IL2↓, 9,   IL2↑, 1,   IL22↓, 1,   IL23↓, 4,   IL33↓, 2,   IL4↓, 10,   IL4↑, 6,   IL5↓, 3,   IL5↑, 1,   IL6↓, 132,   IL6↑, 3,   IL8↓, 28,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 14,   Imm⇅, 1,   Imm↝, 1,   INF-γ↓, 2,   Inflam?, 1,   Inflam↓, 321,   Inflam↑, 5,   IP-10/CXCL-10↓, 1,   IRF3↓, 4,   LPS↓, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M2 MC↑, 1,   pol-M2 MC↑, 2,   Macrophages↓, 1,   MCP1/CCL2↓, 15,   MCP1/CCL2↑, 1,   MCT1↓, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 10,   NeuroI↓, 9,   Neut↓, 1,   NF-kB?, 1,   NF-kB↓, 366,   NF-kB↑, 9,   p‑NF-kB↓, 9,   NK cell↑, 1,   NLRP3↓, 41,   NLRP3↑, 2,   p‑p50↓, 1,   p65↓, 8,   p‑p65↓, 3,   PAF↓, 1,   PGE1↓, 1,   PGE2↓, 47,   RAGE↓, 5,   RANTES↓, 3,   SOCS-3↓, 1,   Th2↓, 1,   TLR1↓, 2,   TLR2↓, 8,   TLR3↓, 1,   TLR4↓, 36,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 190,   TNF-α↑, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 5,   Ach↑, 6,   AChE↓, 42,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 10,   BDNF↓, 3,   BDNF↑, 35,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 6,   GABA↑, 3,   GABA↝, 1,   GDNF↑, 1,   MAOA↓, 5,   MAOA↝, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95?, 1,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN1↑, 1,   SYT1↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 5,   Aβ↓, 60,   Aβ42↓, 3,   BACE/β-secretase↓, 21,   BACE/β-secretase↑, 1,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 21,   XO↓, 2,   β-Amyloid↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   END↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 70,   BioAv↑, 77,   BioAv⇅, 2,   BioAv↝, 48,   BioAv∅, 1,   BioEnh↑, 5,   ChemoSen↑, 1,   CompStab↓, 1,   CompStab↑, 3,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 47,   Dose∅, 1,   eff↓, 4,   eff↑, 31,   GSTA1↑, 6,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 17,   Half-Life∅, 1,   MRP↓, 1,   P-gp/ABCB1↓, 4,   P450↓, 2,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 37,   ALB↝, 1,   ALP↓, 5,   AST↓, 44,   BG↓, 2,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 4,   BMD↑, 8,   BP↓, 12,   BP↝, 1,   BUN?, 1,   BUN↓, 5,   Calcium↑, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 1,   creat↓, 11,   CRP↓, 9,   EGFR↓, 1,   HbA1c↓, 1,   hs-CRP↓, 1,   IL6↓, 132,   IL6↑, 3,   IRes↑, 1,   IRes↝, 1,   LDH↓, 15,   LDH↑, 1,   Mag↑, 1,   NOS2↓, 4,   RAGE↓, 5,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 2,   VitD↑, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 2,   AntiAge↑, 6,   antiAll?, 1,   antiAll↑, 30,   AntiArt↑, 15,   AntiCan↓, 1,   AntiCan↑, 28,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 32,   AntiMyl↑, 1,   antiPs↑, 3,   AntiTum↓, 1,   AntiTum↑, 5,   cardioP?, 2,   cardioP↑, 85,   cardioP⇅, 1,   CardioT↓, 1,   chemoP↑, 15,   chemoPv↑, 10,   cognitive↓, 1,   cognitive↑, 79,   cognitive↝, 1,   cough?, 1,   diuretic↑, 4,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 91,   Learn↑, 5,   memory?, 1,   memory↑, 80,   Mood↑, 2,   motorD↑, 13,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 191,   NP/CIPN↓, 2,   Obesity↓, 18,   OS↑, 6,   Pain↓, 10,   QoL↑, 1,   radioP↑, 16,   RenoP↓, 1,   RenoP↑, 32,   Risk↓, 5,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 15,   toxicity↓, 43,   toxicity↑, 4,   toxicity↝, 13,   toxicity∅, 12,   Weight↓, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↓, 1,   AntiFungal↑, 7,   AntiP↑, 2,   AntiViral↑, 14,   Bacteria↓, 32,   Bacteria↑, 1,   Diar↓, 2,   Dysb↓, 1,   GutMicro↑, 31,   Inf↓, 1,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 742

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
71 Curcumin
43 Thymoquinone
28 Resveratrol
27 Fisetin
25 Lycopene
24 Propolis -bee glue
24 Quercetin
21 EGCG (Epigallocatechin Gallate)
20 Baicalein
20 Betulinic acid
19 Sulforaphane (mainly Broccoli)
19 Silymarin (Milk Thistle) silibinin
17 Apigenin (mainly Parsley)
17 Luteolin
16 Ashwagandha(Withaferin A)
16 Garcinol
16 Magnolol
15 Alpha-Lipoic-Acid
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
13 Hydrogen Gas
13 isoorientin
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
12 Emodin
12 Honokiol
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Kaempferol
11 Rosmarinic acid
10 Radiotherapy/Radiation
10 Beta-Caryophyllene
10 Morin
9 Magnetic Fields
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Disulfiram
8 Isoliquiritigenin
8 Licochalcone A
8 Melatonin
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Hyperoside
7 phytic acid, Inositol hexakisphosphate
7 Matrine
7 Nimbolide
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Isovitexin
6 Ginger/6-Shogaol/Gingerol
6 Deguelin
6 Indole-3-carbinol
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Gambogic Acid
6 Licorice
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Hydroxycinnamic-acid
5 Ellagic acid
5 Piperine
5 Ferulic acid
5 Graviola
5 HydroxyTyrosol
5 Piperlongumine
5 Rutin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Ursolic acid
4 Cynaropicrin
4 Formononetin
4 Paclitaxel/Taxol
4 Hibiscus sabdariffa
4 Inositol
4 lambertianic acid
4 Lutein
3 1,8-Cineole
3 Auranofin
3 Astragalus
3 Citric Acid
3 5-fluorouracil
3 beta-glucans
3 xanthohumol
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cucurbitacin
3 methylseleninic acid
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 Gallic acid
3 Genistein (soy isoflavone)
3 Geraniol
3 Orlistat
3 Moringa oleifera
3 Oleuropein
3 Marjoram (Origanum majorana)
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorophyllin
2 Echinacea
2 Photodynamic Therapy
2 CUSP9
2 Diindolylmethane
2 D-limonene
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Evodiamine
2 Flaxseed/Linseed
2 Ginkgo biloba
2 Ginkgolide B
2 Ginkgetin
2 Ginseng
2 Grapeseed extract
2 Proanthocyanidins
2 Inulin Prebiotic
2 Ivermectin
2 SDG/lignans
2 Linalool
2 Methyl salicylate / Sweet Birch oil
2 Magnetic Field Rotating
2 Lemon Balm/Melissa officinalis
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
2 Vitexin
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Cannabidiol
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Oxygen, Hyperbaric
1 Lecithin
1 Galantamine
1 Cyclopamine
1 Diclofenac
1 Dipyridamole
1 methotrexate
1 Ascorbyl Palmitate
1 flavonoids
1 Bortezomib
1 Fucoidan
1 Ginkgolic acids
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 isoflavones
1 isoquercitrin
1 Juglone
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 Methylglyoxal
1 doxorubicin
1 Neem
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Phenolic Acids
1 Polyphenols
1 Perilla
1 buckwheat sprouts
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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