OS Cancer Research Results

OS, overall survival: Click to Expand ⟱
Source:
Type:
Overall survival

Scientific Papers found: Click to Expand⟱
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
5281- 3BP,    A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- Case Report, Var, NA
Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, ChemoSen↑, OS↑, QoL↑, toxicity↝,
5467- AF,    Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth
- in-vitro, Lung, NA
TrxR↓, eff↑, Dose↝, OS↑, eff↑,
5440- AG,    Astragalus Injection Enhances the Sensitivity of Clinical Cancer Patients to Chemotherapy: A Systematic meta-Analysis
- Review, Var, NA
ChemoSen↑, OS↑,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4394- AgNPs,    Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways
- in-vivo, lymphoma, NA
OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,
4362- AgNPs,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
333- AgNPs,  HPT,    Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells
- in-vivo, GBM, NA
OS↑,
332- AgNPs,  Rad,    Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy
- in-vivo, GBM, NA
OS↑,
331- AgNPs,  Rad,    Silver nanoparticles: a novel radiation sensitizer for glioma?
- vitro+vivo, GBM, NA
OS↑,
305- AgNPs,    Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer
- Case Report, HNSCC, NA
OS↑, Dose↓, BioAv↝, toxicity↓, Remission↑, other↝, other↝, other↝, Dose↝, BioAv↝,
345- AgNPs,    Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model
- vitro+vivo, lymphoma, NA
OS↑, ascitic↓,
5349- Akk,  immuno,    Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial
- Case Report, Melanoma, NA
eff↑, OS↑, eff↑,
287- ALA,  HCA,  Lyco,    Metabolic treatment of cancer: intermediate results of a prospective case series
- Case Report, Var, NA
PSA↓, OS↑,
290- ALA,  HCA,    A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results
- vitro+vivo, Melanoma, B16-F10
TumCG↓, OS↑,
303- ALA,  LDN,    The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol
- Case Report, PC, NA
OS↑,
271- ALA,  VitC,  LDN,    The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol
- Case Report, RCC, NA
OS↑, Weight↑, TumVol↓,
274- ALA,  LDN,    Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases
- Human, PC, NA
OS↑,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
5325- ALC,    L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial
- Trial, PC, NA
Weight↑, QoL↑, OS↑,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
5360- almon,  BEV,    Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series
- Case Report, NSCLC, NA
BBB↑, Dose↝, eff↓, OS↑,
5361- almon,    Abstract CT190: A multicenter, open-label, single-arm, phase II study: The third generation EGFR tyrosine kinase inhibitor almonertinib for pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (APOLLO)
- Trial, NSCLC, NA
EGFR↓, OS↑, Dose↝,
4759- antiOx,  Chemo,    Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization
- Review, Var, NA
TumCD↑, TumCG↓, ROS⇅, Synergy↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,
4760- antiOx,  Chemo,    Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials
- Review, Var, NA
ChemoSen∅, OS↑, chemoP↑,
4765- antiOx,  Chemo,    Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity
- Review, Var, NA
chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,
1541- Api,  EGCG,    Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence
- Human, CRC, NA
OS↑, Remission↓, Dose∅,
2593- Api,    Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo
- in-vivo, BC, 4T1
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↑, ROS↑, p‑PI3K↓, PI3K↓, Akt↓, NRF2↓, AntiTum↑, OS↑,
5416- ASA,    Cancer Incidence and Mortality With Aspirin in Older Adults
- Trial, Var, NA
Risk∅, OS∅,
5406- ASA,    Adjuvant aspirin therapy and colorectal cancer survival
- Trial, CRC, NA
Dose↝, OS∅,
2002- Ash,    Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology
- Review, Var, NA
antiOx↑, Inflam↓, TumCP↓, OS↑, RadioS↑, radioP↑, chemoP↑,
3671- Ash,    Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model
- in-vivo, AD, NA
*OS↑, *BACE/β-secretase↓,
5372- ATO,    Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
- Trial, APL, NA
Remission↑, OS↑, toxicity↓,
5375- ATO,    Improved Outcome with ATRA-Arsenic Trioxide Compared to ATRA-Chemotherapy in Non-High Risk Acute Promyelocytic Leukemia – Updated Results of the Italian-German APL0406 Trial on the Extended Final Series
- Trial, APL, NA
eff↑, OS↑,
5374- ATO,    A pharmacokinetic and safety study of oral arsenic trioxide in patients with acute promyelocytic leukemia
- Trial, APL, NA
toxicity↓, OS↑,
5453- ATV,    Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates
- Trial, Var, NA
OS↑, eff↑, other↝,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- Review, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, Synergy↑, OS↑, Remission↑,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
- Review, Var, NA
Apoptosis↑, selectivity↑, Synergy↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5581- B-Gluc,    Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases
- Human, GC, NA
OS↑,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5567- B-Gluc,    Trained immunity: A new player in cancer immunotherapy
- Review, Var, NA
Imm↑, ROS↑, Apoptosis↑, OS↑, TumMeta↓, Dose↝,
5566- B-Gluc,    The effects of beta-glucan on human immune and cancer cells
- Review, Var, NA
Imm↑, *BioAv↓, OS↑, ChemoSen↑,
5576- B-Gluc,  Chemo,    Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy
- Trial, GC, NA
OS↑, eff↑,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
5578- B-Gluc,    A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group
- Trial, GC, NA
OS↑, QoL↑,
5580- B-Gluc,    Lentinan, a Shiitake Mushroom β-Glucan, Downregulates the Enhanced PD-L1 Expression Induced by Platinum Compounds in Gastric Cancer Cells
- in-vitro, GC, MKN45
PD-L1↓, MAPK↓, OS↑, AntiTum↑, Imm↑,
5499- Ba,    Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, F-actin↓, TumVol↓, OS↑, 12LOX↓, VEGF↓, angioG↓,
1376- BBR,  immuno,    Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation
- in-vivo, Melanoma, NA
OS↑, ROS↑, NQO1↓, ICD↑,

Showing Research Papers: 1 to 50 of 364
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 364

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   Copper↓, 1,   CoQ10↑, 1,   cystine↓, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 10,   GSH↑, 1,   GSH/GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 4,   HO-1↑, 4,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 3,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 5,   NRF2↝, 1,   RNS↑, 1,   ROS↓, 3,   ROS↑, 69,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 5,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   compI↓, 2,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 7,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 3,   PINK1↑, 1,   PleEff↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   adiP↑, 1,   ALAT↓, 2,   ALAT↑, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CRM↑, 2,   ECAR↓, 1,   FAO↑, 1,   GAPDH↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 10,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 3,   HMG-CoA↓, 2,   KeyT↑, 1,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MethCyc↓, 1,   NAD↓, 1,   PDK1 / PDPK1↓, 2,   PDKs↓, 2,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 5,   Pyruv↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   TCA?, 1,   TS↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 36,   Bak↑, 2,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-xL↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 18,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 7,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   ICD↑, 1,   iNOS↓, 1,   iNOS↑, 1,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   p38↑, 2,   p‑p38↑, 1,   Pyro↑, 1,   RIP3↑, 1,   survivin↓, 1,   TumCD↑, 9,   XIAP↓, 2,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   p‑Akt↓, 3,   p‑Akt↑, 1,   BRAF↓, 2,   CaMKII ?, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 5,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 1,   ERK5↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JNK↑, 3,   MAPK↓, 5,   MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 12,   mTOR↑, 1,   OR13G1?, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 12,   PI3K↑, 1,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 2,   c-Raf↓, 1,   RAS↓, 3,   RIP1↑, 1,   Sp1/3/4↓, 1,   STAT3↓, 7,   p‑STAT3↑, 1,   TK1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 2,   cJun↑, 1,   cMyc↓, 5,   FOXM1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   GATA3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC8↓, 1,   KISS1↑, 1,   miR-34a↑, 1,   Myc↓, 1,   MYCN↑, 1,   OCT4↓, 1,   OLIG2↓, 1,   other?, 1,   other↓, 2,   other↑, 2,   other⇅, 1,   other↝, 17,   other∅, 2,   OV6↓, 1,   SD↑, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 2,   tumCV↓, 8,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSPs↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   LC3B↑, 1,   LC3I↑, 1,   LC3II↑, 2,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 13,   DNArepair↓, 3,   DNArepair↑, 2,   hTERT/TERT↓, 2,   P53?, 1,   P53↓, 1,   P53↑, 16,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 9,   PCNA↓, 6,   Telomerase↓, 1,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 6,   CDKN1C/p57↑, 1,   CHK1↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 10,   E2Fs↓, 1,   Ki-67↓, 11,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 3,   p‑pRB↓, 1,   p‑RB1↓, 1,   TubPol↓, 2,   TumCCA↑, 31,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   AXIN1↑, 2,   CD133↓, 3,   CSCs↓, 6,   Diff↑, 1,   EP2↓, 1,   GH↓, 1,   Gli1↓, 5,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 9,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   PTCH2↓, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 64,   TumCG↑, 1,   TumCG⇅, 1,   TumCG↝, 1,   TumCP↓, 32,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↑, 1,   Ca+2↑, 4,   Cofilin↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 9,   EMT↓, 11,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   fascin↓, 1,   GLI2↓, 1,   GLI3↑, 1,   KRAS↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 5,   N-cadherin↓, 6,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 11,   TumCMig↓, 17,   TumMeta?, 1,   TumMeta↓, 22,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 1,   Vim↓, 4,   Zeb1↓, 2,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   E-sel↓, 1,   E-sel↑, 1,   eNOS↑, 1,   Hif1a↓, 10,   Hif1a↝, 1,   Hypoxia↓, 2,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 19,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CellMemb↑, 1,   CLDN1↓, 1,   EPR↑, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP↓, 15,   MMP↑, 2,   MPT↑, 1,   SVCT-2∅, 1,   TRPM7↓, 1,   TRPV1↓, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 7,   CD44↓, 1,   CD8+↑, 8,   COX2/PTGS2↓, 11,   CXCc↓, 1,   CXCL12↓, 1,   CXCL9↓, 1,   DCells↓, 1,   DCells↑, 3,   FOXP3↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↑, 2,   IL17↑, 1,   IL18↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 14,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↑, 17,   Imm↝, 2,   Inflam↓, 12,   pol-M1↝, 1,   Macrophages↑, 1,   NF-kB↓, 14,   NF-kB↑, 1,   NK cell↑, 6,   NLRP3↑, 1,   p65↓, 2,   p65↑, 1,   PD-L1↓, 4,   PDT+↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 4,   PSA∅, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF7/TCF1↓, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 12,   TNF-α↑, 3,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↑, 1,   pH↝, 3,   e-pH↑, 3,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 2,   PPARγ↑, 1,   RANKL↓, 1,   testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 10,   BioAv↝, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 53,   ChemoSen∅, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 12,   Dose↝, 85,   Dose∅, 15,   eff↓, 13,   eff↑, 58,   eff⇅, 1,   eff↝, 15,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 4,   RadioS?, 1,   RadioS↑, 21,   selectivity↑, 36,   Synergy↑, 39,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 7,   ALAT↓, 2,   ALAT↑, 1,   AR↓, 1,   ascitic↓, 1,   AST↓, 1,   AST↑, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 5,   BRAF↓, 2,   BRCA1↑, 1,   CA125↓, 2,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 5,   EstroRS/ERS↑, 1,   Ferritin↓, 2,   FOXM1↓, 1,   hTERT/TERT↓, 2,   IL6↓, 14,   IL6↑, 1,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   Myc↓, 1,   PD-L1↓, 4,   PSA↓, 4,   PSA∅, 1,   TP53↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AEs∅, 1,   AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 12,   antiNeop↑, 3,   AntiTum↓, 1,   AntiTum↑, 15,   Appetite↑, 2,   BowelM↑, 3,   breath↑, 2,   cachexia↓, 2,   cardioP↑, 5,   chemoP↑, 16,   chemoPv↑, 2,   ChemoSideEff↓, 5,   cognitive↑, 2,   CR↑, 3,   DCR↑, 3,   EFS↑, 1,   fatigue↓, 4,   hepatoP↑, 4,   LC↑, 4,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 4,   ORR↑, 2,   ORR∅, 1,   OS?, 4,   OS↓, 5,   OS↑, 294,   OS⇅, 1,   OS↝, 2,   OS∅, 16,   Pain↓, 8,   PFS?, 1,   PFS↓, 1,   PFS↑, 3,   PFS∅, 2,   QoL↑, 31,   QoL∅, 3,   radioP↑, 13,   Remission↓, 1,   Remission↑, 9,   RFS↑, 1,   Risk↓, 18,   Risk↑, 1,   Risk↝, 1,   Risk∅, 3,   Sleep↑, 2,   Strength↑, 4,   toxicity↓, 24,   toxicity↑, 4,   toxicity↝, 10,   toxicity∅, 4,   TR↑, 1,   TTP↑, 1,   TumVol↓, 32,   TumVol↑, 2,   TumW↓, 5,   Weight↓, 4,   Weight↑, 13,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 582

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 21,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 7,   GSH↑, 9,   GSR↑, 3,   GSTs↑, 1,   HDL↑, 1,   HO-1↑, 6,   Iron↝, 1,   lipid-P↓, 7,   MDA↓, 5,   MDA↑, 1,   MPO↓, 2,   NFE2L2↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 12,   RNS↓, 1,   ROS↓, 36,   mt-ROS↓, 2,   selenoP↑, 2,   SOD↑, 13,   SOD1↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   EGF↓, 1,   Insulin↓, 1,   mtDam↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 2,   ALAT∅, 1,   AMPK↑, 7,   CRM↑, 1,   glucose↓, 4,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 3,   H2S↑, 1,   HK2↑, 1,   LDL↓, 3,   NADPH↓, 2,   PFK↑, 1,   PKM2↑, 1,   SIRT1↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   ASC?, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 3,   Casp9↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   AMPKα↑, 1,   CREB↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 1,   PTEN↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↑, 1,   other↓, 1,   other↑, 4,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 3,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSF1↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGF-1↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   MMP9↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GLUT4↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   GM-CSF↑, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL17↑, 1,   IL18↓, 1,   IL1β↓, 5,   IL23↓, 2,   IL4↑, 1,   IL6↓, 6,   Imm↑, 1,   Inflam↓, 27,   IP-10/CXCL-10↓, 1,   IP-10/CXCL-10↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3?, 1,   mPGES-1↓, 1,   Neut↑, 1,   NF-kB↓, 11,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 11,   Treg lymp↝, 1,   TREM-1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 4,   EndoR↑, 1,   monoA↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   Aβ42↓, 1,   BACE/β-secretase↓, 2,   p‑tau↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 4,   BioEnh↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↑, 10,   Half-Life?, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 3,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT∅, 1,   ALP↓, 2,   AST↓, 3,   AST∅, 1,   BG↓, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 1,   IL6↓, 6,   IRes↓, 1,   LDH↓, 2,   SpO2↑, 1,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 2,   AntiDiabetic↑, 4,   cachexia↓, 1,   cardioP↑, 15,   chemoP↑, 1,   cognitive↑, 13,   hepatoP↑, 6,   memory↑, 12,   memory∅, 1,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 20,   neuroP↝, 1,   Obesity↓, 2,   OS↓, 1,   OS↑, 46,   Pain↓, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 4,   Strength↑, 2,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 12,   toxicity↝, 5,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 3,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↓, 1,   GutMicro↑, 8,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,  
Total Targets: 235

Scientific Paper Hit Count for: OS, overall survival
18 Chemotherapy
18 Magnetic Fields
18 Magnetic Field Rotating
14 Vitamin C (Ascorbic Acid)
14 Hydrogen Gas
13 Radiotherapy/Radiation
9 diet Methionine-Restricted Diet
8 Silver-NanoParticles
8 Hyperthermia
8 immunotherapy
8 beta-glucans
8 Dichloroacetate
8 Selenium
8 MCT, metronomic chemo
7 Alpha-Lipoic-Acid
7 capecitabine
7 Curcumin
7 diet Plant based
7 itraconazole
7 Melatonin
5 HydroxyCitric Acid
5 cetuximab
5 diet FMD Fasting Mimicking Diet
5 mebendazole
5 Metformin
5 Bicarbonate(Sodium)
5 Phenylbutyrate
4 Bevacizumab (brand Avastin)
4 EGCG (Epigallocatechin Gallate)
4 Gemcitabine (Gemzar)
4 Fucoidan
4 Phenethyl isothiocyanate
4 Ramucirumab (CYRAMZA)
4 Selenite (Sodium)
3 3-bromopyruvate
3 Lycopene
3 low dose naltrexone
3 almonertinib
3 Anti-oxidants
3 Aspirin
3 Arsenic trioxide
3 Atorvastatin
3 Carvacrol
3 Cimetidine
3 Oxygen, Hyperbaric
3 Quercetin
3 Exercise
3 diet Short Term Fasting
3 Honokiol
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 iodine
3 Juglone
3 nivolumab
3 Mistletoe/Viscum album Extracts
3 nicotinamide adenine dinucleotide
3 Sulfasalazine
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
3 Urolithin
2 Acetyl-l-carnitine
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Bufalin/Huachansu
2 Bifidobacterium
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Docetaxel
2 Chlorogenic acid
2 chaetocin
2 Choline
2 Citric Acid
2 Calorie Restriction Mimetics
2 Resveratrol
2 Spermidine
2 diet Fermented Foods
2 Sulforaphane (mainly Broccoli)
2 Disulfiram
2 eicosapentaenoic acid
2 Flaxseed/Linseed
2 Orlistat
2 hydroxychloroquine
2 imatinib
2 isoflavones
2 Lapatinib
2 Lactoferrin/Talactoferrin
2 ipilimumab
2 Patchouli Oil (Pogostemon cablin)
2 Propolis -bee glue
2 Piperine
2 doxorubicin
2 EMF
2 Spirulina(Arthrospira/Limnospira)
2 Thymoquinone
2 VitK3,menadione
1 2-DeoxyGlucose
1 Auranofin
1 Astragalus
1 Akkermansia
1 Baicalein
1 Berberine
1 Brucea javanica
1 Bacopa monnieri
1 Boron
1 Black Rice, Oryza sativa
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celastrol
1 chitosan
1 Chocolate
1 Chrysin
1 Coenzyme Q10
1 Hydroxycinnamic-acid
1 Artemisinin
1 Dasatinib/Phyrago
1 Cisplatin
1 salinomycin
1 Deguelin
1 Bortezomib
1 diet Ketogenic
1 D-limonene
1 Copper and Cu NanoParticles
1 Echinacea
1 Emodin
1 Electrical Pulses
1 Folic Acid, Vit B9
1 Formononetin
1 Garcinol
1 Geraniol
1 5-fluorouracil
1 Ginkgolide B
1 Gossypol/AT-101
1 Paclitaxel/Taxol
1 Isoliquiritigenin
1 Isovitexin
1 Vitexin
1 Trastuzumab
1 Licochalcone A
1 SDG/lignans
1 Luteolin
1 Mung Bean Sprouts
1 Lutein
1 Magnolol
1 Magnesium
1 Mangiferin
1 Helleborus niger extracts – Christmas Rose
1 Naringin
1 Noscapine
1 Piperlongumine
1 Radio Frequency
1 Shankhpushpi
1 Iron
1 Salvia miltiorrhiza
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitamin K2
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:229  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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