p53 Wildtype Cancer Research Results

p53 Wildtype, p53 Wildtype: Click to Expand ⟱
Source: HalifaxProj(upregulate)
Type:
The term "wildtype" refers to the normal, non-mutated form of the p53 protein. In this state, p53 is functional and can effectively carry out its tumor-suppressing activities.
Wildtype p53 can induce cell cycle arrest, promote DNA repair, initiate apoptosis (programmed cell death), and regulate other genes involved in these processes. It responds to various stress signals, such as DNA damage, hypoxia, and oncogene activation.

In Cancers with Wild-Type p53:
Intact p53 function is associated with better control of cell growth and an improved response to DNA damage.
Retention of wild-type p53 generally indicates a more favorable prognosis.

Wild-Type p53:
Classic tumor-suppressing role (i.e., anti-tumorigenic). It prevents the proliferation of cells with damaged DNA.
Mutant p53:
Can be considered protumorigenic due to loss of normal function and, in certain cases, due to “gain-of-function” activities.
Scientific Papers found: Click to Expand⟱
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
1490- RES,    Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
- Review, Var, NA
TumCCA↑, ROS↑, Ca+2↑, MMP↓, ATP↓, TOP1?, P53↑, p53 Wildtype∅, Akt↓, mTOR↓, EMT↓, *BioAv↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   GSR↑, 1,   GSTs↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   MDM2↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   mTOR↓, 2,   TOP1?, 1,  

Migration ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   Vim↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   P450↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   chemoPv↑, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: p53 Wildtype, p53 Wildtype
1 Carvone
1 Resveratrol
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:237  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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