CD31/PECAM-1 Cancer Research Results

CD31/PECAM-1, platelet endothelial cell adhesion molecule-1 (PECAM-1): Click to Expand ⟱
Source:
Type: marker
CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane receptor that plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling.
High CD31 expression has been linked to poor prognosis and increased metastasis. (except Leukemia and brain cancers).
CD31 is a marker that is commonly used to identify microvessels in tissue sections.
Scientific Papers found: Click to Expand⟱
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31/PECAM-1↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp/ABCB1↓, PD-1↝,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
9203- BITC,    Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,
9167- BITC,    Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, CD31/PECAM-1↓, VEGF↓, PCNA↓, CDK4↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓,
9166- BITC,    Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3
- in-vitro, PC, Bxpc-3 - in-vitro, PC, Panc02
STAT3↓, TumCMig↓, TumCI↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31/PECAM-1↓, NF-kB↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
9286- BR, BRJ,    Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis
- in-vivo, Lung, NA
TumNum↓, CD31/PECAM-1↓, Casp3↑, Apoptosis↑, angioG↓, PARP↑, chemoPv↑,
7174- CHA,    Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
- vitro+vivo, OS, OS-RC-2
SUV39H↓, TumCG↓, NOTCH1↓, CD31/PECAM-1↓, VEGF↓, toxicity↓, Ki-67↓, angioG↓,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2/PTGS2↓, GM-CSF↓, angioG↓, VEGF↓, CD31/PECAM-1↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2/PTGS2↓, CD31/PECAM-1↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓, CompStab↓,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT/SLC7A11↑, *GPx4↑, *Wound Healing↑, *CD31/PECAM-1↑, *mt-ROS↓,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
8007- JG,    Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis
- in-vitro, GBM, U251
Pin1↓, AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, TumCMig↓, angioG↓, VEGF↓, CD31/PECAM-1↓, TGF-β1↓,
8290- LE,    Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells
- vitro+vivo, Pca, DU145
*toxicity↝, Apoptosis↑, TumCCA↑, TumCMig↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, COX2/PTGS2↓, VEGF↓, MMP9↓, ICAM-1↓, VCAM-1↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8323- LIN,  doxoR,    Efficacy of Combination Therapy with Linalool and Doxorubicin Encapsulated by Liposomes as a Two-in-One Hybrid Carrier System for Epithelial Ovarian Carcinoma
- vitro+vivo, Ovarian, NA
ChemoSen↑, TumCG↓, Ki-67↓, CD31/PECAM-1↓, Casp3↑, *toxicity↓, chemoP↑, *BioAv↓, EPR↑,
972- MAG,    Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells
- vitro+vivo, Bladder, T24/HTB-9
angioG↓, VEGF↓, H2O2↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Akt↓, mTOR↓, P70S6K↓, 4E-BP1↓, TumCG↓, CD31/PECAM-1↓, CA↓,
1812- Oxy,    Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer
- in-vitro, Lung, A549 - in-vivo, Lung, NA - in-vitro, NA, BEAS-2B
TumCG↓, CD31/PECAM-1↑, P53↓, Dose∅, other↑, Apoptosis↑, Hif1a↑, selectivity↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
7942- TQ,    Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice
- in-vitro, Asthma, NA
*IL4↓, *IL5↓, *CD31/PECAM-1↓, *VEGFR2/KDR/Flk1↓, *PI3K↓, *Akt↓, *SLIT2↑, *Inflam↓, *VEGF↓, *antiAll↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

Showing Research Papers: 1 to 30 of 30

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 30

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   GSH↓, 1,   GSH↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 5,   Trx↑, 1,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 2,   compII↓, 1,   compIII↓, 1,   ETC↓, 1,   MKK7↓, 1,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATP↓, 2,   FAO↑, 1,   FASN↓, 1,   p‑GSK‐3β↓, 2,   HK2↓, 1,   lactateProd↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 2,   Apoptosis↑, 12,   BAX↑, 5,   Bcl-2↓, 10,   Bcl-xL↓, 5,   BIM↓, 1,   BIM↑, 2,   Casp↑, 3,   Casp3↑, 9,   cl‑Casp3↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 2,   cl‑Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   FasL↑, 1,   IAP1↓, 2,   iNOS↓, 2,   p38↓, 1,   p38↑, 1,   survivin↓, 3,   TRAIL⇅, 1,   TRAILR↑, 1,   XIAP↓, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   cSrc↓, 1,   EGFR↓, 3,   ERK↓, 2,   p‑ERK↓, 1,   HER2/EBBR2↓, 1,   p‑IKKα↓, 1,   ILK↓, 1,   JAK2↓, 2,   JNK↑, 2,   MAPK↓, 1,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 5,   P70S6K↓, 1,   PI3K↓, 8,   Raf↓, 1,   SHP1↓, 1,   STAT3↓, 6,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 1,   cMyc↓, 1,   FOXO1↓, 1,   FOXO3↓, 1,   HATs↑, 1,   HDAC↓, 2,   OCT4↓, 1,   other↑, 1,   other↝, 1,   SOX2↓, 1,   SUV39H↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 2,   P53↓, 2,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 4,   PCNA↓, 7,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 1,   Ki-67↓, 10,   P21↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CSCs↓, 3,   Ki-67↓, 10,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH2↑, 1,   TumCG↓, 9,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   CA↓, 1,   CCN2/CTGF↓, 1,   E-cadherin↑, 3,   EMT↓, 3,   MMP2↓, 8,   MMP3↓, 1,   MMP9↓, 7,   MMPs↓, 3,   N-cadherin↓, 2,   PAI-1/SERPINE1↑, 1,   Snail↓, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 1,   TumCMig↓, 4,   TumMeta↓, 5,   TumMeta↑, 1,   uPA↓, 4,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 12,   CD31/PECAM-1↓, 24,   CD31/PECAM-1↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 8,   Hif1a↑, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 19,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CXCR4↓, 1,   GM-CSF↓, 2,   ICAM-1↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL2↑, 1,   IL6↓, 1,   IL8↓, 1,   Imm↝, 1,   Inflam↓, 3,   MDSCs↓, 2,   MyD88↓, 1,   NF-kB↓, 11,   p65↓, 1,   PD-1↝, 1,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 5,   CompStab↓, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose↝, 4,   Dose∅, 1,   eff↑, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 3,   selectivity↑, 2,   selectivity↝, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ascitic↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 1,   IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 3,   fatigue↓, 1,   hepatoP↑, 1,   neuroP↑, 2,   OS↑, 1,   Pin1↓, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 1,   TumNum↓, 2,   TumVol↓, 3,   TumW↓, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 223

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 1,   ROS↓, 3,   mt-ROS↓, 1,   SOD↑, 2,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Ferroptosis↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑ERK↑, 1,   IκB?, 1,   mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↑, 1,  

Migration(tgid=13) ⓘ

N-cadherin↑, 2,   SLIT2↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 3,   VEGF↓, 1,   VEGF↑, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Eos↓, 1,   IL10↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 1,   Inflam↓, 4,   PGE2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   MAOB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   eff↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 1,   cognitive↑, 2,   memory↑, 1,   neuroP↑, 3,   toxicity↓, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 66

Scientific Paper Hit Count for: CD31/PECAM-1, platelet endothelial cell adhesion molecule-1 (PECAM-1)
4 Benzyl isothiocyanate
2 Berberine
2 Boswellia (frankincense)
2 Curcumin
2 Licorice
2 Linalool
2 Thymoquinone
1 Artemisinin
1 Beetroot
1 chaetocin
1 Formononetin
1 Fucoidan
1 Garcinol
1 Cisplatin
1 Hibiscus sabdariffa
1 phytic acid, Inositol hexakisphosphate
1 Isothiocyanates
1 Allyl isothiocyanate
1 Phenethyl isothiocyanate
1 Sulforaphane (mainly Broccoli)
1 Juglone
1 doxorubicin
1 Magnolol
1 Oxygen, Hyperbaric
1 Psoralidin
1 Silymarin (Milk Thistle) silibinin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:295  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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