TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
Scientific Papers found: Click to Expand⟱
6476- 1,8-Cin,    Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line
- in-vitro, AML, NA
TumCG↓, selectivity↑, Apoptosis↑,
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5258- 3BP,    3-bromopyruvate: Targets and outcomes
- Review, Var, NA
Glycolysis↓, TumCG↓,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5472- AF,    Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion
- in-vitro, Cerv, HeLa
TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, Synergy↑, eff↑, MMP↓, AIF↑, toxicity↓,
1000- AG,  5-FU,    Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation
- vitro+vivo, BC, 4T1
TumCG↓, TumCCA↑, Apoptosis↑, *IL2↑, *TNF-α↑, *IFN-γ↑,
944- AG,    Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model
- vitro+vivo, CRC, NA
Glycolysis↓, lactateProd↓, TumCG↓,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5433- AG,    Mechanisms of astragalus polysaccharide enhancing STM2457 therapeutic efficacy in m6A-mediated OSCC treatment
- vitro+vivo, OS, NA
other↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, N-cadherin↓, TumCG↓,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5437- AG,    Modulation of PD-L1 by Astragalus polysaccharide attenuates the induction of melanoma stem cell properties and overcomes immune evasion
- in-vivo, Melanoma, B16-F10
CSCs↓, CD133↓, BMI1↓, PD-L1↓, TumCG↓,
5436- AG,    Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice
- in-vivo, HCC, NA
TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,
4551- AgNPs,  FBZ,    Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy
- in-vivo, Lung, NA
eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,
4593- AgNPs,  Chit,    Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells
- in-vitro, BC, MCF7
*Bacteria↓, *Wound Healing↑, TumCG↓,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, Synergy↑,
4413- AgNPs,  Anzaroot,    Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells
- in-vitro, BC, MCF7
chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,
4407- AgNPs,    Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231)
- in-vitro, BC, MDA-MB-231
antiOx↑, TumCG↓,
4426- AgNPs,    Antiangiogenic properties of silver nanoparticles
- Study, Var, NA
angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,
4362- AgNPs,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
374- AgNPs,    Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
ER Stress↑, DNAdam↑, ROS↑, Apoptosis↑, GSH/GSSG↓, NADPH/NADP+↓, TumCG↓, UPR↑,
358- AgNPs,    Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer
- vitro+vivo, Ovarian, SKOV3
TumCCA↑, ROS↑, Casp3↑, TumCG↓, cycD1/CCND1↓,
347- AgNPs,    The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
- Review, Var, NA
ROS↑, TumCCA↑, ER Stress↑, TumCG↓, TumCP↓, DNAdam↑, P53↑, MMP2↓, MMP9↓, angioG↓, TumMeta↓, MMP↓, Casp3↑, cycD1/CCND1↓, PCNA↓, TNF-α↓, IL6↓, P21↑, p27/CDKN1B↑, CDK2↓, CDK4↓, Fas↑, FADD↑, BAX↑, PUMA↑, Bcl-2↓, Bcl-xL↓, ATP↓, PDK1 / PDPK1↓, Glycolysis↓, Cyt‑c↑, cl‑PARP↑, TRF2↓, hTERT/TERT↓, ETC↓, GSH↓, eff↑, ChemoSen↑, EMT↓,
379- AgNPs,    Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
- in-vivo, Lung, H1299
NF-kB↓, Bcl-2↓, Casp3↑, survivin↑, TumCG↓,
380- AgNPs,  QC,  CA,  Chit,    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
- in-vitro, MG, U118MG
TumCG↓,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
1290- AL,    Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells
- in-vitro, OS, LM8
Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
544- AL,    Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations
- Review, Var, NA
Risk↓, ChemoSideEff↓, TumCG↓, NF-kB⇅,
2647- AL,    The Mechanism in Gastric Cancer Chemoprevention by Allicin
- Review, GC, NA
ChemoSen↓, TumCG↓, TumCCA↑, ER Stress↑, Apoptosis↑, Casp↑, DR5↑,
2648- AL,    Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
- in-vitro, OS, SaOS2 - in-vivo, OS, NA
ROS↑, TumCG↓, TumAuto↑, Wnt↓, β-catenin/ZEB1↓, MALAT1↓,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
288- ALA,  HCA,  CAP,  Octr,    Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin
TumCG↓,
285- ALA,  HCA,    Tolerance of oral lipoid acid and hydroxycitrate combination in cancer patients: first approach of the cancer metabolism research group
- Human, Var, NA
PI3K↝, AMPK↝, TumCG↓, *toxicity↓, Weight∅,
280- ALA,    Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
- in-vivo, Lung, A549
p‑mTOR↑, TumCG↓, TumAuto↓, p‑P70S6K↑,
290- ALA,  HCA,    A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results
- vitro+vivo, Melanoma, B16-F10
TumCG↓, OS↑,
291- ALA,  HCA,  MET,  DFC,    Metabolic therapies inhibit tumor growth in vivo and in silico
- in-vivo, Melanoma, B16-F10 - in-vivo, Lung, LL/2 (LLC1) - in-vivo, Bladder, MBT-2
TumCG↓,
296- ALA,    Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo
- vitro+vivo, neuroblastoma, SK-N-SH - vitro+vivo, BC, SkBr3
TumCG↓, Casp3↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
258- ALA,    Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells
- in-vitro, BC, MDA-MB-231
TumCG↓, p‑Akt↓, Akt↓, HER2/EBBR2↓, Bcl-2↓, BAX↑, Casp3↑,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
5326- ALC,    L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
- vitro+vivo, Liver, HepG2
TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
6602- Anamu,    Dibenzyl Trisulfide Inhibits the Proliferation and Metastasis of Nsclc Via Suppressing Jak/Stat3 Signal Pathway
- vitro+vivo, NSCLC, H1299 - in-vitro, NSCLC, A549
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, BAX↑, Bcl-2↓, EMT↓, p‑STAT3↓, TumCG↓,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT/SLC7A11↓, MMP↓, ATP↓,

Showing Research Papers: 1 to 50 of 940
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 940

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   antiOx⇅, 1,   Catalase↓, 5,   Catalase↑, 4,   ENOX2↓, 2,   Fenton↑, 7,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 19,   GSH↓, 51,   GSH↑, 3,   i-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 1,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 1,   H2O2↓, 4,   H2O2↑, 10,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 8,   HO-1↑, 10,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 11,   Iron∅, 1,   i-Iron↑, 3,   c-Iron↑, 1,   Keap1↑, 1,   lipid-P↓, 4,   lipid-P↑, 20,   MDA↓, 2,   MDA↑, 11,   NADH↓, 1,   NADHdeh?, 1,   NADPH/NADP+↓, 2,   NOX2↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 2,   Nrf1↓, 1,   Nrf1↑, 1,   NRF2↓, 15,   NRF2↑, 12,   NRF2↝, 1,   ox-PrxI↑, 1,   RNS↑, 2,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 19,   ROS↑, 262,   ROS⇅, 3,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 9,   SOD↓, 5,   SOD↑, 4,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 6,   TAC↓, 3,   TBARS↓, 1,   Thiols↓, 1,   i-Thiols↓, 1,   TKT↝, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↓, 2,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 3,   xCT/SLC7A11↓, 12,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 3,   IronCh↑, 1,   LIP↑, 1,   NCOA4↑, 2,   Tf↑, 1,   TfR1/CD71↓, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   p‑CDC2↓, 1,   CDC25↓, 8,   CDC25↑, 2,   CDC25↝, 1,   compI↓, 1,   EGF↓, 2,   ETC↓, 7,   HSP60/HSPD1↓, 4,   HSP60/HSPD1↑, 1,   Insulin↓, 3,   mitResp↓, 7,   mitResp↑, 2,   mtDam↓, 2,   mtDam↑, 26,   OCR↓, 9,   OCR↑, 5,   OXPHOS↓, 4,   OXPHOS↑, 10,   mt-OXPHOS↓, 1,   PDH↓, 1,   PDH↑, 6,   p‑PDH↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 1,   PINK1↑, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 3,   ACC↓, 1,   ACC-α↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 3,   Alanine↓, 1,   ALAT↓, 5,   ALAT∅, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 22,   AMPK↝, 1,   p‑AMPK↑, 4,   ARG↓, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 37,   ATP↑, 3,   i-ATP↑, 1,   Buty↑, 1,   CAIX/CA9↑, 1,   cAMP↓, 1,   cAMP⇅, 1,   i-citrate↑, 1,   CRM↑, 3,   DHODH↓, 1,   ECAR↓, 7,   ECAR∅, 1,   ENO1↓, 3,   FABP4↑, 1,   FABP5/E-FABP↓, 1,   FASN↓, 6,   FDG↓, 1,   FFA/NEFA↓, 1,   G6PD↓, 1,   GALNT10↓, 1,   GAPDH↓, 4,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 26,   GlucoseCon↑, 3,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 56,   Glycolysis↑, 2,   GPI↓, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HK2↓, 24,   HK2∅, 1,   HMG-CoA↓, 6,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   IDH1↑, 1,   KeyT↑, 1,   lactateProd↓, 29,   lactateProd↑, 2,   LDHA↓, 19,   LDHA∅, 1,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 2,   MATs↓, 1,   MCT4↓, 2,   MethCyc↓, 1,   NAD↓, 2,   NADPH↓, 1,   NADPH↑, 1,   NPC1L1↓, 1,   PA↑, 2,   PDK1 / PDPK1↓, 7,   PDKs↓, 4,   PFK↓, 4,   PFK1↓, 5,   PFKP↓, 3,   PKM1↑, 1,   PKM2↓, 21,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 2,   Pyruv↓, 3,   Pyruv↑, 1,   R5P↝, 1,   SCFAs↑, 1,   SIRT1↓, 8,   SIRT1↑, 3,   SREBF2↓, 1,   SREBP1/SREBF1↓, 3,   TCA↓, 2,   TCA↑, 2,   TPI↓, 1,   TS↓, 1,   Warburg↓, 14,   Warburg↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 1,   Apoptosis↓, 12,   Apoptosis↑, 361,   Apoptosis∅, 2,   mt-Apoptosis↑, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 3,   Bak↑, 3,   BAX↓, 2,   BAX↑, 106,   BAX↝, 1,   Bax:Bcl2↑, 32,   Bcl-2?, 1,   Bcl-2↓, 139,   Bcl-2↑, 1,   Bcl-xL↓, 31,   Bcl-xL↑, 2,   BID↓, 1,   BID↑, 5,   cl‑BID↑, 1,   BIM↑, 5,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 36,   Casp↝, 1,   Casp1↓, 2,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp12↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 125,   cl‑Casp3↓, 1,   cl‑Casp3↑, 47,   proCasp3↓, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 9,   Casp9↓, 1,   Casp9↑, 61,   p‑Casp9↑, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 9,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 69,   Cyt‑c↝, 1,   Diablo↑, 1,   DR5↑, 11,   FADD↑, 3,   Fap1↓, 1,   Fas↓, 4,   Fas↑, 7,   FasL↓, 2,   FasL↑, 4,   Ferroptosis↓, 1,   Ferroptosis↑, 30,   GSDMC↑, 1,   GSDMD↑, 1,   cl‑GSDMD↑, 1,   cl‑GSDME↑, 3,   GSDME-N↑, 1,   HEY1↓, 2,   IAP1↓, 6,   IAP2/BIRC3↓, 3,   ICD↑, 2,   iNOS↓, 3,   Mcl-1↓, 15,   MDM2↓, 6,   MDM2↑, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 5,   NOXA↑, 3,   p38↓, 4,   p38↑, 13,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 2,   Pyro↑, 11,   RIP1↑, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 42,   survivin↑, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 26,   TumCD∅, 1,   TUNEL↑, 1,   XIAP↓, 15,   YAP/TEAD↓, 8,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 110,   Akt↑, 6,   p‑Akt↓, 40,   p‑Akt↑, 1,   AKT1↓, 3,   BCAP↓, 1,   BRAF↓, 2,   BRAF↑, 1,   CaMKII ↓, 3,   CIP2A↓, 1,   cMET↓, 4,   CREB↓, 2,   p‑CREB↓, 1,   cSrc↓, 1,   DDIT4?, 1,   DYRK1B↓, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 23,   ERK↑, 6,   ERK↝, 1,   p‑ERK↓, 15,   p‑ERK↑, 3,   e-ERK↑, 1,   FLT3↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 9,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 4,   p‑IGF-1R↓, 1,   IGFR↓, 3,   p‑IGFR↓, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 3,   p‑JAK1↓, 2,   JAK2↓, 13,   p‑JAK2↓, 4,   JNK↓, 3,   JNK↑, 15,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 3,   cl‑JNK↑, 1,   LIFR/CD118↓, 1,   MAPK↓, 16,   MAPK↑, 11,   p‑MAPK↑, 2,   MARK4↓, 1,   MEK↓, 3,   MEK↑, 1,   p‑MEK↓, 1,   mTOR↓, 60,   mTOR↑, 7,   p‑mTOR↓, 8,   p‑mTOR↑, 1,   mTORC2↓, 2,   mTORC2↑, 1,   p‑p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 2,   p‑P70S6K↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 3,   PDGFRB↓, 1,   PI3K↓, 75,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 6,   PI3K/Akt↓, 4,   PI3K/Akt↑, 1,   p‑PI3k/Akt/mTOR↓, 1,   PKA↓, 2,   p‑PKA↓, 1,   PKCδ↓, 5,   p‑PKCδ↓, 1,   PPP2R1A↑, 1,   PTEN↓, 2,   PTEN↑, 15,   PTK2B / PYK2↓, 1,   Raf↓, 3,   RAS↓, 5,   Rictor↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   Sp1/3/4↓, 11,   Sp1/3/4↑, 1,   Src↓, 3,   STAT↓, 4,   STAT3↓, 61,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 16,   p‑STAT3↑, 2,   STAT4↑, 1,   STAT5↓, 2,   p‑STAT5↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↑, 10,   BRD4↓, 1,   CBP↓, 1,   ChrMod↑, 2,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 35,   cMyc↑, 1,   DNMT1↓, 6,   DNMT3A↓, 1,   DNMT3B↓, 2,   DNMTs↓, 4,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 3,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   GATA3↓, 1,   H19↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↑, 2,   H3K4↓, 1,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 23,   HDAC↑, 1,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HMTs↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-106b↓, 1,   miR-122-5p↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-141↑, 1,   miR-155↓, 1,   miR-199↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-205↑, 2,   miR-21↓, 2,   miR-22↑, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-330-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 4,   miR-375↑, 1,   miR-486↑, 1,   miR-542↓, 1,   Myc↓, 5,   MYCN↑, 1,   OCT4↓, 13,   OLIG2↓, 1,   other?, 1,   other↓, 4,   other↑, 8,   other↝, 27,   PhotoS↑, 1,   SD↑, 1,   SOX2↓, 8,   SOX9↓, 2,   SUV39H↓, 7,   SUZ12↓, 1,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 76,   tumCV∅, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 17,   CHOP/DDIT3↝, 1,   eIF2α↑, 5,   p‑eIF2α↑, 6,   ER Stress↑, 37,   ERStress↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 11,   HSP27↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP72↑, 1,   HSP90↓, 7,   HTRA↓, 2,   IRE1↑, 4,   NPL4↓, 1,   PDI↑, 1,   PERK↓, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome↓, 2,   UPR↓, 1,   UPR↑, 10,   XBP-1↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG3↓, 1,   ATG3↑, 1,   ATG5↑, 6,   ATG7↑, 1,   autoF↓, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 13,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3B↑, 3,   LC3B-II↑, 3,   LC3II↓, 1,   LC3II↑, 11,   LC3s↓, 1,   LC3s↑, 2,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 7,   p62↑, 6,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 3,   TumAuto↑, 55,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   ATR↑, 1,   DFF45↓, 1,   DNAdam↑, 60,   mt-DNAdam↑, 1,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 3,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 1,   P53?, 1,   P53↓, 3,   P53↑, 62,   P53↝, 3,   P53∅, 1,   p‑P53↑, 6,   PARP↓, 2,   PARP↑, 13,   p‑PARP↑, 2,   cl‑PARP↑, 59,   PARP1↓, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 21,   SAPK↑, 1,   Telomerase↓, 5,   TOP1↓, 2,   TOP2↓, 4,   TOP2↑, 1,   TP53↑, 1,   TRF2↓, 1,   γH2AX↑, 8,   γH2AX↝, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↓, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 14,   CDK1↑, 1,   CDK1↝, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 17,   CDK2↑, 1,   p‑CDK2↓, 1,   CDK4↓, 26,   CDK4↑, 3,   CDK4/6↓, 1,   CDK6↓, 7,   CDK6↑, 3,   CDK8↓, 1,   cellSen↑, 1,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   Chk2↑, 2,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 6,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 19,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 69,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 1,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 4,   GADD45A↑, 2,   Ki-67↓, 51,   Ki-67↑, 1,   mitA↑, 2,   p19↑, 1,   P21↓, 3,   P21↑, 53,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 18,   PLK1↓, 1,   pRB↓, 1,   pRB↑, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   cl‑RB1↓, 1,   Securin↓, 2,   TubPol↓, 2,   TumCCA↓, 7,   TumCCA↑, 240,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 7,   ALDH1A1↓, 1,   ALDH1A3↓, 1,   Axin2↑, 1,   BMI1↓, 3,   BMP7/OP1↓, 1,   CD133↓, 12,   CD133↑, 1,   CD24↓, 4,   CD34↓, 2,   CEBPB?, 1,   cFos↓, 4,   CSCs↓, 47,   CSCs↑, 2,   CSCsMark↓, 1,   Diff↑, 13,   EP4/PTGER4↑, 1,   FGF↓, 1,   FOSL1↑, 1,   Gli↓, 1,   Gli1↓, 20,   Gli1∅, 1,   GTPBP4↓, 1,   HH?, 1,   HH↓, 19,   HMGCR↓, 2,   HMGCR↑, 1,   Id1↓, 1,   IGF-1↓, 10,   IGF-1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   Ki-67↓, 51,   Ki-67↑, 1,   Let-7↑, 1,   LRP6↓, 2,   mTORC1↓, 6,   Nanog↓, 10,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH2↑, 1,   NOTCH3↓, 3,   p300↓, 1,   Piezo1↑, 2,   PTCH1↓, 8,   PTCH2↓, 1,   Shh↓, 7,   Smo↓, 8,   Smo∅, 1,   STAT1↓, 1,   Sufu↓, 1,   Sufu↑, 1,   TAZ↓, 2,   TumCG?, 10,   TumCG↓, 915,   TumCG↑, 17,   TumCG⇅, 2,   TumCG↝, 3,   TumCG∅, 6,   TumCP↓, 201,   TumCP↑, 6,   Wnt↓, 26,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AKR1C2↓, 1,   AntiAg↑, 2,   AP-1↓, 3,   AP-1↝, 1,   ARG1/2↑, 1,   CA↓, 2,   Ca+2↓, 2,   Ca+2↑, 25,   Ca+2↝, 1,   i-Ca+2↑, 4,   Cav1↓, 1,   Cav1↑, 1,   CCAT1↓, 1,   CD11b↓, 1,   i-Chl↑, 1,   COL11A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 38,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 60,   EMT↝, 1,   EpCAM↓, 1,   FAK↓, 11,   FAK↑, 1,   Fibronectin↓, 1,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 5,   ITGA5↓, 2,   ITGB1↓, 3,   LEF1↓, 2,   MALAT1↓, 2,   MMP1↓, 3,   MMP13↓, 2,   MMP15↓, 1,   MMP2↓, 49,   proMMP2↓, 1,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 64,   MMPs↓, 7,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   N-cadherin↓, 24,   N-cadherin↝, 1,   Na+↑, 2,   NCAM↓, 1,   NFAT↑, 1,   p‑p44↓, 1,   PAK1↓, 1,   PCBP1↓, 1,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 9,   p‑SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 14,   SPARC↑, 2,   talin↓, 1,   TET1↓, 1,   TGF-β↓, 7,   TGF-β1↓, 2,   TIMP1↑, 4,   TIMP2↑, 4,   TRIB3↑, 2,   TSP-1↑, 2,   TumCA↓, 3,   TumCI?, 1,   TumCI↓, 105,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 116,   TumCMig↑, 2,   TumMeta?, 1,   TumMeta↓, 87,   TumMeta↑, 5,   TumPF↓, 3,   Twist↓, 7,   TXNIP↓, 1,   TXNIP↑, 2,   uPA↓, 6,   uPAR↓, 2,   Vim↓, 24,   Zeb1↓, 7,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 1,   α-tubulin↓, 3,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 37,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 83,   angioG↑, 2,   CD31/PECAM-1↓, 7,   CD31/PECAM-1↑, 1,   ECM/TCF↓, 3,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 49,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 4,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 77,   VEGF↑, 2,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 12,   VM↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   CellMemb↓, 1,   CellMemb↑, 4,   CLDN1↓, 1,   CLDN7↑, 1,   EPR↑, 9,   GLUT1↓, 11,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   IBI↑, 1,   K+↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 124,   MMP↑, 5,   MPT↑, 4,   Na+↑, 2,   NHE1↓, 1,   TRPM7↑, 2,   TRPV1↓, 1,   TRPV1↑, 1,   TRPV1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CCL20↑, 1,   CD155↓, 1,   CD25+↓, 2,   CD4+↓, 3,   CD4+↑, 9,   CD44↓, 17,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 11,   cDC2↓, 2,   p‑cDC2↓, 2,   cGAS–STING↑, 1,   CLP↑, 1,   COX2/PTGS2↓, 28,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL9↓, 1,   CXCR4↓, 8,   DCells↑, 3,   DR4↑, 2,   DR6↑, 1,   FOXP3↓, 1,   FoxP3+↓, 2,   Gal-3↓, 2,   GM-CSF↓, 3,   HLA-I/II↑, 1,   HMGB1↓, 4,   HMGB1↑, 1,   ICAM-1↓, 6,   IFN-γ↓, 1,   IFN-γ↑, 3,   IL1↓, 5,   IL1↑, 2,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL12↑, 4,   IL18↑, 2,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↑, 1,   IL6↓, 21,   IL6↑, 2,   IL8↓, 7,   Imm↑, 19,   Imm↝, 1,   Inflam↓, 22,   Inflam↝, 1,   pol-M1↑, 1,   M2 MC↓, 1,   M2 MC↑, 1,   pol-M2 MC↓, 2,   Macrophages↑, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NAF1↓, 1,   NF-kB↓, 101,   NF-kB↑, 4,   NF-kB⇅, 1,   NF-kB↝, 1,   p‑NF-kB↓, 3,   NK cell↑, 7,   NLRP3↓, 2,   NLRP3↑, 3,   p50↓, 1,   p65↓, 6,   p‑p65↓, 3,   PD-1↓, 2,   PD-L1↓, 19,   PD-L2↓, 1,   PGE2↓, 9,   PSA↓, 9,   T-Cell↑, 7,   TCF↓, 3,   Th1 response↑, 1,   TILs↑, 2,   TIM-3↓, 2,   TLR4↓, 3,   TLR4↝, 1,   TNF-α↓, 13,   TNF-α↑, 4,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GFAP↓, 1,   pH↓, 2,   pH↑, 3,   pH↝, 1,   e-pH↑, 10,   i-pH↓, 1,   i-pH↑, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   AR↓, 16,   COMT↑, 1,   CYP11A1↓, 1,   CYP19↓, 1,   DHT↓, 1,   ER-α36↓, 1,   ER(estro)↓, 2,   ERα/ESR1↓, 2,   ERβ/ESR2↑, 2,   FGF21↓, 1,   GR↓, 1,   HSD3B↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↑, 1,   RANKL↓, 2,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   BioAv↓, 25,   BioAv↑, 21,   BioAv↝, 11,   ChemoSen?, 1,   ChemoSen↓, 4,   ChemoSen↑, 148,   ChemoSen∅, 2,   CompStab↓, 2,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 6,   Dose↑, 7,   Dose⇅, 2,   Dose↝, 99,   Dose∅, 13,   DrugR↓, 1,   eff?, 1,   eff↓, 82,   eff↑, 103,   eff↝, 15,   eff∅, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 7,   Half-Life∅, 2,   MDR1↓, 6,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 11,   P-gp/ABCB1↝, 1,   P-gp/ABCB1∅, 1,   P450↓, 1,   P450↑, 1,   RadioS?, 1,   RadioS↑, 43,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 3,   selectivity↑, 122,   selectivity∅, 1,   Synergy↑, 93,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 5,   ALAT∅, 1,   AR↓, 16,   ascitic↓, 2,   AST↓, 4,   AST∅, 1,   BG↓, 4,   BMD↑, 3,   BP↓, 1,   BRAF↓, 2,   BRAF↑, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 2,   Ferritin↓, 3,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 9,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 21,   IL6↑, 2,   KeyT↑, 1,   LDH↓, 7,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 5,   PD-L1↓, 19,   PSA↓, 9,   SUZ12↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 60,   AntiCan?, 1,   antiCG↓, 1,   antiNeop↑, 3,   antiNeop∅, 1,   AntiTum↑, 38,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 3,   cardioP↑, 7,   CardioT↓, 1,   chemoP↓, 1,   chemoP↑, 23,   chemoPv↑, 17,   ChemoSideEff↓, 7,   cognitive↑, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↑, 5,   hepatoP∅, 1,   kidSt↓, 1,   motorD↑, 1,   neuroP↑, 4,   Obesity↓, 1,   OS↑, 59,   OS⇅, 1,   Pain↓, 5,   PDE4↓, 1,   QoL↑, 7,   QoL∅, 2,   radioP↑, 7,   Remission↑, 5,   Risk↓, 25,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 4,   toxicity↓, 45,   toxicity↑, 4,   toxicity⇅, 1,   toxicity↝, 14,   toxicity∅, 9,   TumVol↓, 35,   TumW↓, 20,   Weight↑, 4,   Weight∅, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 2,   Bacteria↓, 1,   GutMicro↑, 11,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 1129

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 49,   ARE↑, 1,   Catalase↑, 12,   DPPH↓, 1,   GPx↑, 12,   GPx1↑, 1,   GSH↓, 2,   GSH↑, 19,   GSR↑, 3,   GSTs↑, 6,   H2O2↓, 2,   HO-1↑, 11,   lipid-P↓, 13,   MDA↓, 11,   NQO1↑, 1,   NRF2↑, 16,   ROS↓, 52,   ROS↑, 4,   ROS∅, 2,   mt-ROS↓, 1,   SOD↑, 18,   SOD1↑, 1,   SOD2↓, 1,   TBARS↓, 1,   Trx↓, 1,   Trx↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   ETC↝, 1,   mitResp↑, 1,   OCR↓, 1,   OXPHOS↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 5,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   ATP↑, 1,   ECAR∅, 1,   glucose↓, 3,   GlucoseCon↑, 3,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   LDL↓, 6,   lipidLev↓, 1,   NAD↓, 1,   NADPH↓, 1,   PONs↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 3,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   iNOS↓, 7,   iNOS↑, 1,   necrosis↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑Akt↑, 1,   Akt2↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↑, 2,   IKKα↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 2,   mTOR↑, 1,   PTEN↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   other?, 1,   other↓, 2,   other↑, 6,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↑, 1,   neuroG↑, 1,   TumCG↓, 4,   TumCG↑, 1,   TumCG∅, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 3,   Ca+2↑, 2,   Ca+2∅, 1,   i-Ca+2↓, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP9↓, 1,   MMPs↓, 1,   Snail↑, 1,   TGF-β↓, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   Twist↑, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   HIF2a↑, 1,   NO↓, 5,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   BBB↝, 2,   CellMemb↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   MMP↓, 1,   MMP↑, 2,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 13,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 2,   IL1β↓, 7,   IL2↑, 1,   IL6↓, 14,   IL8↓, 2,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 55,   Inflam↑, 1,   IRF3↓, 1,   MyD88↓, 1,   Neut↑, 1,   NF-kB↓, 15,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 5,   TLR2↓, 2,   TLR4↓, 5,   TNF-α↓, 13,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 1,   AChE↓, 8,   AChE↑, 1,   AChE↝, 1,   BDNF↓, 1,   BDNF↑, 6,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 11,   BioAv↑, 24,   BioAv↝, 7,   BioEnh↑, 3,   CompStab↑, 1,   CYP3A2↓, 1,   Dose?, 2,   Dose⇅, 1,   Dose↝, 4,   eff↑, 4,   Half-Life↓, 3,   Half-Life↝, 3,   Half-Life∅, 1,   P450↓, 3,   selectivity↑, 3,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 6,   ALP↓, 1,   AST↓, 7,   BMD↑, 2,   BP↓, 3,   colonLen↑, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6↓, 14,   LDH↓, 2,   LDH↑, 1,   TC↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 3,   AntiArt↑, 4,   AntiCan↑, 6,   AntiDiabetic↑, 8,   AntiTum↑, 1,   cardioP↑, 26,   chemoP↑, 5,   chemoPv↑, 6,   cognitive↑, 12,   DCR∅, 1,   hepatoP↑, 20,   memory↑, 13,   motorD↑, 1,   neuroP↑, 36,   ORR∅, 1,   OS↑, 3,   Pain↓, 2,   PDE4↓, 1,   PFS∅, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 4,   Stroke↓, 2,   toxicity↓, 38,   toxicity↑, 3,   toxicity↝, 7,   toxicity∅, 12,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 5,   Bacteria↓, 11,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 5,  
Total Targets: 292

Scientific Paper Hit Count for: TumCG, Tumor cell growth
29 Curcumin
29 Magnetic Fields
17 Quercetin
17 Phenethyl isothiocyanate
15 Magnetic Field Rotating
14 Berberine
14 EGCG (Epigallocatechin Gallate)
14 Sulforaphane (mainly Broccoli)
13 Silver-NanoParticles
13 Chemotherapy
13 Shikonin
12 Vitamin C (Ascorbic Acid)
12 Magnolol
12 Bicarbonate(Sodium)
11 Alpha-Lipoic-Acid
11 Melatonin
11 Baicalein
11 Garcinol
11 phytic acid, Inositol hexakisphosphate
10 Capsaicin
10 Apigenin (mainly Parsley)
10 chaetocin
10 Fisetin
9 Cucurbitacin
9 Resveratrol
9 Silymarin (Milk Thistle) silibinin
9 Dichloroacetate
9 Deguelin
9 Formononetin
9 Phenylbutyrate
8 Astragalus
8 Radiotherapy/Radiation
8 Artemisinin
8 salinomycin
8 diet FMD Fasting Mimicking Diet
8 Emodin
8 Gambogic Acid
8 Ginkgetin
8 Honokiol
8 Ivermectin
8 Matrine
8 Magnesium
8 Pterostilbene
8 Urolithin
7 Allicin (mainly Garlic)
7 HydroxyCitric Acid
7 Ashwagandha(Withaferin A)
7 immunotherapy
7 Boron
7 Boswellia (frankincense)
7 Crocetin
7 Isoliquiritigenin
7 Lycopene
7 mebendazole
7 methylseleninic acid
6 Metformin
6 Cisplatin
6 Betulinic acid
6 Chrysin
6 Coenzyme Q10
6 Gemcitabine (Gemzar)
6 diet Methionine-Restricted Diet
6 Sulfasalazine
6 Indole-3-carbinol
6 Inulin Prebiotic
6 itraconazole
6 Juglone
6 Rosmarinic acid
6 α-Santalol/Sandalwood oil
5 chitosan
5 doxorubicin
5 Paclitaxel/Taxol
5 Berbamine
5 Beta-Caryophyllene
5 Centella asiatica / Gotu kola → asiaticoside
5 Citric Acid
5 Diindolylmethane
5 Dandelion Root
5 Eugenol
5 Gallic acid
5 Graviola
5 isoquercitrin
5 Linalool
5 Luteolin
4 3-bromopyruvate
4 Fenbendazole
4 Astaxanthin
4 Atorvastatin
4 Dipyridamole
4 Brucea javanica
4 Butyrate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Cynaropicrin
4 Docosahexaenoic Acid
4 Disulfiram
4 Evodiamine
4 Flaxseed/Linseed
4 Genistein (soy isoflavone)
4 Hydrogen Gas
4 Hyperoside
4 Isobavachalcone
4 Inositol
4 Nimbolide
4 Marjoram (Origanum majorana)
4 Terpinen-4-ol / Tea Tree Oil
4 Piperine
4 Piperlongumine
4 Selenite (Sodium)
4 Thymoquinone
4 Vitamin K2
4 VitK3,menadione
3 Caffeic acid
3 Diclofenac
3 Baicalin
3 Bufalin/Huachansu
3 brusatol
3 Bruteridin(bergamot juice)
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Carvacrol
3 Celastrol
3 Chlorogenic acid
3 Selenium NanoParticles
3 Copper and Cu NanoParticles
3 Photodynamic Therapy
3 tamoxifen
3 Ellagic acid
3 eicosapentaenoic acid
3 Fucoidan
3 Geraniol
3 Ginger/6-Shogaol/Gingerol
3 Glabrescione B
3 Gossypol/AT-101
3 HydroxyTyrosol
3 MCT, metronomic chemo
3 Licochalcone A
3 Licorice
3 Lemongrass Extract/Citral
3 SDG/lignans
3 Modified Citrus Pectin
3 Niclosamide (Niclocide)
3 Propyl gallate
3 Plumbagin
3 Aflavin-3,3′-digallate
2 2-DeoxyGlucose
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Anethole/trans-Anethole
2 Fennel Oil/Foeniculum vulgare
2 Ascorbyl Palmitate
2 Biochanin A
2 Bifidobacterium
2 Bromelain
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Polyphenols
2 Cyclopamine
2 Oxygen, Hyperbaric
2 diet Short Term Fasting
2 D-limonene
2 Ginkgo biloba-EGb 761
2 ferumoxytol
2 Galloflavin
2 Ginkgo biloba
2 Ginkgolide B
2 Grapeseed extract
2 Hydroxycinnamic-acid
2 iodine
2 Isovitexin
2 Kaempferol
2 Lutein
2 Methylene blue
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Oroxylin-A
2 Oleuropein
2 Orlistat
2 Psoralidin
2 Hyperthermia
2 EMF
2 Oxaliplatin
2 Spermidine
2 Ursolic acid
2 Vitexin
2 Whole Body Vibration
1 1,8-Cineole
1 5-fluorouracil
1 Anzaroot, Astragalus fasciculifolius Bioss
1 octreotide
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 Anti-oxidants
1 5-Aminolevulinic acid
1 Aloe anthraquinones
1 beta-glucans
1 temozolomide
1 Bacopa monnieri
1 Bullatacin
1 Caffeine
1 urea
1 Cat’s Claw
1 Cannabidiol
1 Celecoxib
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Bicalutamide
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dasatinib/Phyrago
1 Bortezomib
1 Date Fruit Extract
1 diet Ketogenic
1 diet Plant based
1 Ormeloxifene (Centchroman)
1 Aspirin
1 Zinc
1 Echinacea
1 PXD, phenoxodiol
1 Sorafenib (brand name Nexavar)
1 Electrical Pulses
1 erastin
1 Eurycomanone
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Ginkgolic acids
1 Hibiscus sabdariffa
1 Lactobacillus
1 probiotics
1 Laetrile B17 Amygdalin
1 Lapachol
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 MCT oil
1 Methyl Jasmonate
1 vp16, etoposide
1 Methylglyoxal
1 magnetic nanoparticles
1 Morin
1 Mistletoe/Viscum album Extracts
1 Naringin
1 Noscapine
1 Aromatherapy
1 Parthenolide
1 Broccoli
1 raloxifen
1 Salvia officinalis
1 Vorinostat
1 Selenium
1 irinotecan
1 Salvia miltiorrhiza
1 Saikosaponin B1 and D
1 Sutherlandioside D
1 cetuximab
1 Taurine
1 Tomatine
1 triptolide
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Transarterial Chemoembolization
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:323  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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