TumPF Cancer Research Results

TumPF, Tumor-promoting fibroblasts: Click to Expand ⟱
Source: HalifaxProj(deactivate)
Type:
Tumor-promoting fibroblasts, often referred to as cancer-associated fibroblasts (CAFs), play a significant role in the tumor microenvironment and contribute to cancer progression.
CAFs are derived from various sources, including resident fibroblasts, mesenchymal stem cells, and even epithelial cells through a process called epithelial-to-mesenchymal transition (EMT). They exhibit distinct characteristics compared to normal fibroblasts, including altered gene expression and increased secretion of growth factors and cytokines.
Scientific Papers found: Click to Expand⟱
7185- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, p‑ATM↑, YAP/TEAD↑, p‑JNK↑, TumPF↓, SUV39H↓, TrxR↓, Casp3↑, Trx1↓, H3↓, lactateProd↓, ATP↓, GlucoseCon↓, TumCG↓, Dose↝,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
8575- Matr,    Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3
- in-vitro, GC, SGC-7901
TumPF↓, Apoptosis↑, Fas↑, FasL↑, Casp3↑,
9044- PatchO,    Patchouli oil and its main component patchouli alcohol inhibit colorectal cancer by activating ectopic olfactory receptor
- vitro+vivo, CRC, HCT116
OS↑, TumCG↓, Inflam↓, AMPK↑, Ferroptosis↑, OR13G1?, CaMKII ?, TumPF↓, TumCMig↓, Tumccf↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   NRF2↓, 1,   ROS↑, 3,   Trx1↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATP↓, 2,   GlucoseCon↓, 1,   lactateProd↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 4,   Casp9↑, 2,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 2,   ICD↑, 1,   YAP/TEAD↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CaMKII ?, 1,   p‑JNK↑, 1,   p‑MAPK↑, 1,   mTOR↓, 1,   OR13G1?, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   HMTs↓, 1,   miR-106b↓, 1,   miR-155↓, 1,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 1,   miR-221↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↑, 1,   miR-34a↑, 1,   SUV39H↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑ATM↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Ki-67↓, 2,   Let-7↑, 1,   TumCG↓, 4,   TumCP↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   TumPF↓, 6,   β-catenin/ZEB1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,   PSA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PSA↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 66

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: TumPF, Tumor-promoting fibroblasts
1 chaetocin
1 Ivermectin
1 Juglone
1 Lactobacillus
1 Matrine
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:329  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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