CD8+ Cancer Research Results

CD8+, CD8+ T cell: Click to Expand ⟱
Source:
Type: T cell
CD8+ T cells are "end effectors" of cancer immunity.
Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.
CD8+ T cells, also known as cytotoxic T lymphocytes (CTLs), play a crucial role in the immune response against cancer. They are responsible for identifying and killing cancer cells that present abnormal antigens, which can arise from mutations or viral infections.
Scientific Papers found: Click to Expand⟱
346- AgNPs,  RSQ,    Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment
- in-vivo, Melanoma, SK-MEL-28 - in-vivo, Melanoma, WM35
ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,
541- Akk,    Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut-Liver-Brain Axes?
- Review, Var, NA
GutMicro↑, PD-1↝, CD8+↑, IL8↑,
315- Api,    Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer
- vitro+vivo, PC, Panc02
CK2↓, CD4+↑, CD8+↑, Ikaros↑,
5629- Bif,  ProBio,    Gut microbiota shapes cancer immunotherapy responses
- Review, Var, NA
eff↑, DCells↑, CD8+↑, eff↑, AntiTum↑, other↑, selectivity↑, GutMicro↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
1205- Caff,  immuno,    Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody
- in-vivo, Melanoma, B16-F10
OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,
5892- CAR,  SRF,    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study
- in-vivo, HCC, NA
Hif1a↓, AFP↑, hepatoP↑, STAT3↓, JAK2↓, *CD8+↑, ChemoSen↑, Dose↝, angioG↓,
5819- CBD,    The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence
- Review, Lung, NA
Apoptosis↑, PPARγ↓, mtDam↑, ROS↑, EMT↓, CD8+↑, NK cell↑, ChemoSen↑, ATP↓, glucose↓, Ca+2↑, TRPV2↑,
9142- CC,  immuno,    Combination nivolumab and ipilimumab with and without camu camu in first-line treatment of metastatic renal cell carcinoma (mRCC)
- Trial, RCC, NA
GutMicro↑, CD8+↑, CD4+↑, Synergy?, Dose?,
9136- CC,  immuno,    Two Cases of Durable and Deep Responses to Immune Checkpoint Inhibition-Refractory Metastatic Melanoma after Addition of Camu Camu Prebiotic
- Case Report, Melanoma, NA
GutMicro↑, Ingr?, CD8+↑, CR↑, CR↑, Synergy↑,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
1033- CHr,    Chrysin inhibits hepatocellular carcinoma progression through suppressing programmed death ligand 1 expression
- vitro+vivo, HCC, NA
TumCG↓, CD4+↑, CD8+↑, PD-L1↓,
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,
451- CUR,    The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
- vitro+vivo, HNSCC, SCC15 - vitro+vivo, HNSCC, SNU1076 - vitro+vivo, HNSCC, SNU1041
TumCMig↓, TumCG↓, PD-L1↓, PD-L2↓, Galectin-9↓, EMT↓, T-Cell↑, TILs↑, PD-1↓, TIM-3↓, CD4+↓, CD25+↓, FoxP3+↓, E-cadherin↑, CD8+↑, IFN-γ↑,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
TumCP↑, angioG↓, CD8+↑, GutMicro↑, Synergy↑,
1859- dietFMD,  Chemo,    Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
- in-vitro, BC, 4T1 - in-vivo, Melanoma, B16-BL6
CLP↑, CD8+↑, TumCG↓, HO-1↓, TILs↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
8583- FS,    The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity
- in-vivo, BC, NA
TumCP↓, CD38↓, CD4+↑, CD8+↑, GutMicro↑,
8608- FSO,  Cisplatin,    Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
- in-vivo, Cerv, NA
TumVol↓, TumW↓, ChemoSen↑, *TAC↑, lipid-P↑, CD8+↑, IFN-γ↑, IL4↓, E6↓, E7↓, P53↑,
1283- GA,  immuno,    Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy
- vitro+vivo, CRC, NA
p‑STAT3↓, Treg lymp↓, FOXP3↓, CD8+↑, IFN-γ↑,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
2505- H2,    Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
- Trial, CRC, NA
PGC-1α↑, Dose↝, CD8+↑, OS↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
1021- HNK,    Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer
- in-vivo, Lung, NA
PD-L1↓, T-Cell↑, CD4+↑, CD8+↑, TumCG↓,
7583- I3C,    Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer
- vitro+vivo, CRC, NA
TumCP↓, TumCMig↓, toxicity↓, PTEN↑, CD8+↑,
7776- IBC,    Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation
- vitro+vivo, PC, Panc02
TumCP↓, Apoptosis↑, ROS↑, TumW↓, CD8+↑, M2 MC↓, CSCs↓, antiNeop↑, Imm↑, eff↓, Bcl-2↓, BAX↑,
7652- IP,    Inulin prebiotic reinforces host cancer immunosurveillance via ɣδ T cell activation
- in-vivo, Melanoma, B16-F10
GutMicro↑, Imm↑, CD4+↑, CD8+↑, TumCG↓,
7667- IP,  H2,    Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption
- in-vitro, Var, NA
*AntiTum↑, *other↑, NA↝, *CD4+↑, *CD8+↑, TumCG↓, Imm↑,
8370- LT,    Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer
- vitro+vivo, Colon, NA
TumCP↓, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, Ferroptosis↑, pol-M1↑, CD8+↑, Imm↑,
9267- MFrot,    EXTH-12. Oncomagnetic Monotherapy Mediated Anti-Tumor Immune Response in Glioblastoma
- Review, GBM, NA
TumCP↓, tumCV↓, ROS↑, MMP↓, ATP↓, DNAdam↑, TumCCA↑, TumCG↓, OS↑, Imm↑, CD4+↑, CD8+↑,
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,
221- MFrot,  MF,    Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma
- in-vivo, Liver, NA
OS↑, TumCG↓, IL6↓, GM-CSF↓, CXCc↓, Macrophages↑, DCells↑, CD4+↑, CD8+↑, IL12↑,
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
8911- MO,    Anticancer Potential of Moringa Oleifera in Lung Cancer: A Mini Review of In vitro and In vivo Evidence
- Review, Lung, NA
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp↑, NF-kB↓, EGFR↓, STAT3↓, VEGF↓, eff↑, CD4+↑, CD8+↑,
8917- MO,    Harnessing Moringa oleifera for Immune Modulation in Cancer: Molecular Mechanisms and Therapeutic Potential
- Review, Var, NA
*Ingr↝, *Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *PGE2↓, *PPARγ↑, pol-TregCell↓, NK cell↑, CD8+↑, CD4+↑, *GutMicro↑, Imm↑, TumCMig↓, TumMeta↓, Synergy↑, *toxicity↓, Apoptosis↑, TumCCA↑,
2- MushShi,    The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy
- Human, Ovarian, NA
CD8+↑, Pain↑,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, Synergy↑, ChemoSen↑, ChemoSen↓,
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,
9051- PatchO,    Traditional Patchouli essential oil modulates the host's immune responses and gut microbiota and exhibits potent anti-cancer effects in ApcMin /+ mice
- in-vivo, CRC, NA
AntiTum↑, IBI↑, TJ↑, CD4+↑, CD8+↑, GutMicro↑, SCFAs↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
9036- SP,    The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors
- Trial, Var, NA
Mye↓, CD8+↑, Imm↑, Dose↝,
3141- VitC,    High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer
- in-vitro, CRC, HCT116
Glycolysis↓, Synergy↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,

Showing Research Papers: 1 to 46 of 46

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 46

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CoQ10↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↓, 2,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 1,   ROS?, 1,   ROS↑, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ikaros↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   Insulin↓, 1,   mtDam↑, 2,   OXPHOS↑, 1,   PGC-1α↑, 4,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACAA1↓, 1,   AMPK↑, 1,   ATP↓, 3,   ATP↑, 1,   i-ATP↓, 1,   FABP4↓, 1,   glucose↓, 1,   GlutMet↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   LDHA↓, 1,   PCK1↓, 1,   PFK↓, 1,   PKM2↓, 1,   PLIN1↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↑, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 9,   Bak↓, 1,   BAX↑, 4,   Bcl-2↓, 5,   BID↑, 1,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   Ferroptosis↑, 1,   GSDME-N↑, 1,   IAP2/BIRC3↓, 1,   ICD↑, 1,   Pyro↑, 1,   TumCD↑, 2,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   CaMKII ↑, 1,   CK2↓, 2,   CREB↑, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IGFR↓, 1,   JAK2↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 2,   EZH2↓, 1,   FOXO4↓, 1,   HDAC↓, 1,   miR-124-3p↓, 1,   other↑, 1,   tumCV?, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

i-CRT↓, 1,   ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LAMP2↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 3,   p‑P53↑, 1,   PARP↑, 1,   POLD1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   CDK6↑, 1,   Ki-67↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   FGF↓, 1,   IGF-1↓, 3,   Ki-67↓, 1,   TumCG↓, 13,   TumCP↓, 9,   TumCP↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Ca+2↝, 1,   Cartilage↑, 1,   CD38↓, 1,   COL4↓, 1,   E-cadherin↑, 2,   EMT↓, 4,   Fibronectin↓, 1,   Galectin-9↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   MALAT1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 2,   THBS2↓, 1,   TIMP2↑, 1,   pol-TregCell↓, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumMeta↓, 7,   Vim?, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 3,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↓, 1,   GLUT1↓, 1,   IBI↑, 1,   MMP↓, 4,   TJ↑, 1,   TRPV2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 18,   CD47↓, 1,   CD8+↓, 1,   CD8+↑, 42,   CLP↑, 1,   COX2/PTGS2↓, 1,   CXCc↓, 1,   CXCL12↓, 1,   CXCL9↓, 1,   DCells↑, 5,   FOXP3↓, 1,   FoxP3+↓, 1,   GM-CSF↓, 1,   i-HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 6,   IL1↑, 1,   IL10↑, 1,   IL12↑, 2,   IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   IL4↓, 1,   IL6↓, 2,   IL8↑, 1,   Imm↑, 10,   pol-M1↑, 1,   M2 MC↓, 2,   Macrophages↑, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NK cell↑, 5,   PD-1↓, 2,   PD-1↝, 1,   PD-L1↓, 4,   PD-L2↓, 1,   PDT+↓, 1,   T-Cell↑, 3,   Th1 response↑, 1,   TILs↑, 2,   TIM-3↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 1,   TAMS↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 7,   Dose?, 1,   Dose↝, 8,   eff↓, 3,   eff↑, 7,   eff↝, 2,   RadioS↑, 2,   selectivity↑, 3,   Synergy?, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   BG↓, 2,   BMD↑, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EZH2↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   Mye↓, 1,   PD-L1↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiNeop↑, 1,   AntiTum↑, 5,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   CR↑, 2,   hepatoP↑, 2,   NP/CIPN↓, 1,   OS↑, 7,   OS⇅, 1,   Pain↓, 2,   Pain↑, 1,   PFS↑, 1,   QoL↑, 2,   radioP↑, 2,   Remission↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 2,   TumVol↓, 2,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 10,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 248

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 2,   HO-1↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 3,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   ATP↑, 2,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 3,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑JNK↓, 1,   mTOR↓, 2,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,   TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 3,   CD8+↑, 4,   COX2/PTGS2↓, 2,   IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 2,   IL6↑, 1,   Imm↑, 2,   Inflam↓, 4,   LPS↓, 1,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   BChE↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 2,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   creat↓, 2,   IL6↓, 2,   IL6↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   cognitive↑, 1,   hepatoP↑, 2,   motorD↑, 1,   neuroP↑, 4,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 2,   Stroke↓, 1,   toxicity↓, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 107

Scientific Paper Hit Count for: CD8+, CD8+ T cell
5 Magnetic Field Rotating
4 immunotherapy
4 diet FMD Fasting Mimicking Diet
4 Hydrogen Gas
4 Magnetic Fields
2 Camu camu
2 Chemotherapy
2 Inulin Prebiotic
2 Moringa oleifera
2 Bicarbonate(Sodium)
1 Silver-NanoParticles
1 Resiquimod
1 Akkermansia
1 Apigenin (mainly Parsley)
1 Bifidobacterium
1 probiotics
1 α-Bisabolol / Chamomile oil
1 Caffeine
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Chlorogenic acid
1 Chrysin
1 Copper and Cu NanoParticles
1 Curcumin
1 diet Short Term Fasting
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Cisplatin
1 Gallic acid
1 Gambogic Acid
1 Honokiol
1 Indole-3-carbinol
1 Isobavachalcone
1 Luteolin
1 Mushroom Shiitake, AHCC
1 Patchouli Oil (Pogostemon cablin)
1 Resveratrol
1 Spirulina(Arthrospira/Limnospira)
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:344  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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