PGM1 Cancer Research Results

PGM1, Phosphoglucomutase 1: Click to Expand ⟱
Source:
Type:
Phosphoglucomutase 1 (PGM1) is an enzyme that plays a crucial role in glycogen metabolism. Recent studies have shown that PGM1 is overexpressed in various types of cancer, and its expression is associated with cancer progression and prognosis.
Scientific Papers found: Click to Expand⟱
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
7167- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, YAP/TEAD↑, ATM↑, JNK↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCP↓, TrxR↓, Trx1↓, H3K9↓, p‑ATM↑, γH2AX↑, ALDOB↑, ENO3↑, FBP1↑, GSK‐3β↑, HK3↑, PCK1↑, PGK2↑, PGM1↑, PGM3↑, PHKG1↑, PKLR↑, HK2↓, PCNA↓,
933- CUR,  EP,    Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study
- in-vitro, BC, NA
Apoptosis↑, ALDOA↓, ENO2↓, LDHA↓, LDHB↓, PFKP↓, PGK1↓, PGM1↓, PGAM1↓, OXPHOS↑, TCA↑,
1226- OLST,    Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation
- vitro+vivo, GC, NA
PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDOB↑, 1,   ENO3↑, 1,   H3K9↓, 1,   HK3↑, 1,   PGK2↑, 1,   PGM3↑, 1,   PHKG1↑, 1,   PKLR↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

OXPHOS↑, 1,   ROS↑, 1,   Trx1↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   ENO2↓, 1,   FASN↓, 1,   FBP1↑, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 2,   LDHA↓, 2,   LDHB↓, 1,   lipidLev↑, 1,   PCK1↑, 1,   PFKP↓, 1,   PGAM1↓, 1,   PGK1↓, 2,   PGM1↓, 2,   PGM1↑, 1,   PGM1∅, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   JNK↑, 1,   YAP/TEAD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,   HMTs↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mitResp↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   FAO↑, 1,   FASN↓, 1,   PGM1?, 1,   PKM2↓, 1,  

Migration(tgid=13) ⓘ

PKA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: PGM1, Phosphoglucomutase 1
1 Capsaicin
1 chaetocin
1 Curcumin
1 Electrical Pulses
1 Orlistat
1 Vitamin C (Ascorbic Acid)
1 Arsenic trioxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:358  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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