Snail Cancer Research Results

Snail, SNAI1, Snail Family Transcriptional Repressor 1: Click to Expand ⟱
Source:
Type:
Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
1333- AG,    Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, Ki-67↓, TumCP↓, Snail↓, Vim↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, Var, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,
1560- Api,    Apigenin as an anticancer agent
- Review, Var, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
1095- Api,    Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway
- Analysis, Colon, NA
Snail↓, EMT↓, NF-kB↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
210- Api,    Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer
- in-vitro, Pca, DU145
EMT↓, E-cadherin↑, Snail↓, Vim↓,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27/CDKN1B↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, Synergy↑, Synergy↑, Synergy↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5172- Ash,    Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
- in-vitro, CRC, NA
Akt↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Snail↓, Slug↓, β-catenin/ZEB1↓, Vim↓, angioG↓,
1098- BA,    Baicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2
- in-vitro, Nor, MCF10 - in-vivo, NA, NA
*TumCMig↓, *F-actin↓, *E-cadherin↑, *ZO-1↑, *N-cadherin↓, *Vim↓, *Snail↓, *cal2↓, *Ca+2↝,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
9196- BITC,    Benzyl Isothiocyanate Inhibits Epithelial-Mesenchymal Transition in Cultured and Xenografted Human Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, PC, PL45
TumCG↓, EMT↓, E-cadherin↑, OCLN↑, Vim↓, Fibronectin↓, Snail↓, cMET↓, Slug↓,
756- Bor,    Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF7
COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF7
miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,
733- Bor,    The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells
- in-vitro, Lung, NA
Snail↑, ITGB1↑, ITGA5↑, COL1A1↓, LAMA5↑, MMP3↓, Vim↓, E-cadherin↑, EMT↓, Zeb1↑,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, CRC, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1107- CHr,    Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
- in-vitro, BC, NA
TumCP↓, Apoptosis↑, MMP-10↓, E-cadherin↑, Vim↓, Snail↓, Slug↓, EMT↓,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, Var, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
433- CUR,    Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression
- in-vitro, Lung, A549
E-cadherin↓, Vim↓, Slug↓, N-cadherin↓, Snail↓, MMP9↓, EMT↓,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,
6245- Cyc,    Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
- vitro+vivo, PC, NA
HH↓, Snail↓, E-cadherin↑, EMT↓, TumCI↓, ChemoSen↑, TumMeta↓, ALDH↓, eff↑,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
16- Cyc,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
4682- EGCG,    Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
- Review, Var, NA
CSCs↓, EMT↓, ChemoSen↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, TumCP↓, Apoptosis↑, p‑GSK‐3β↓, GSK‐3β↑, β-catenin/ZEB1↓, cMyc↓, XIAP↓, Bcl-2↓, survivin↓, Vim↓, Slug↓, Snail↓,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, Var, NA
Bcl-2↓, survivin↓, XIAP↓, EMT↓, Apoptosis↑, Nanog↓, cMyc↓, OCT4↓, Snail↓, Slug↓, Zeb1↓, TCF↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,

Showing Research Papers: 1 to 50 of 129
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 129

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 6,   NRF2↑, 6,   p‑NRF2↓, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 42,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 4,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 3,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 2,   mtDam↑, 5,   OCR↓, 3,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 8,   GSK‐3β↑, 3,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 5,   lactateProd↓, 2,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 3,   PFK↓, 1,   PFK1↓, 1,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 3,   SIRT1↓, 3,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 39,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 2,   BAX↑, 22,   Bax:Bcl2↑, 1,   Bcl-2↓, 32,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 6,   BNIP3↑, 1,   Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 37,   Casp3∅, 1,   cl‑Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 9,   Casp8↑, 14,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 24,   cl‑Casp9↑, 3,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 24,   Diablo↑, 5,   DR5↑, 8,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   HEY1↓, 2,   iNOS↓, 6,   Mcl-1↓, 12,   MDM2↓, 3,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 4,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 22,   TNFR 1↑, 2,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 7,   XIAP↓, 16,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   p‑Akt↓, 18,   AKT1↓, 2,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   ERK↓, 9,   p‑ERK↓, 7,   ERK5↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 5,   IKKα↑, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 3,   MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 34,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 8,   RAS↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 20,   p‑STAT3↓, 7,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 2,   p‑ATF4↝, 1,   cJun↓, 2,   cMyc↓, 14,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-126↑, 1,   miR-127-5p↑, 2,   miR-139-5p↑, 1,   miR-140↑, 1,   miR-182-5p↓, 1,   miR-200c↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-29b↓, 1,   miR-339-5p↝, 1,   miR-375↑, 1,   miR-592↑, 1,   Myc↓, 4,   OCT4↓, 12,   other↓, 2,   other↑, 1,   other↝, 1,   SOX2↓, 6,   SOX4↓, 1,   SOX9↓, 1,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 10,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 9,   Erlin1↑, 1,   GRP78/BiP↑, 3,   HSP27↓, 3,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 2,   PDI↑, 1,   PERK↑, 2,   p‑PERK↝, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 4,   PARK2↑, 2,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 2,   DNAdam↓, 1,   DNAdam↑, 10,   DNAdam⇅, 1,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 17,   p‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↑, 9,   cl‑PARP↑, 15,   PARP1↑, 1,   PCNA↓, 9,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,   UHRF1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1/2/5/9↓, 1,   CDK2↓, 15,   CDK2↑, 2,   CDK4↓, 11,   CDK4/6↓, 1,   CDK6↓, 9,   CDK8↓, 2,   CHK1↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 5,   E2Fs↓, 2,   Ki-67↓, 6,   MAD↓, 1,   P21↑, 15,   p27/CDKN1B↑, 6,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 27,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   CD133↓, 4,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 24,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 9,   HH↓, 9,   IGF-1↓, 2,   JAG1↓, 1,   Ki-67↓, 6,   LRP6↓, 3,   p‑LRP6↓, 2,   Nanog↓, 10,   NOTCH↓, 10,   NOTCH1↓, 7,   NOTCH1↑, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 2,   PTCH2↓, 1,   Shh↓, 8,   Smo↓, 6,   TumCG?, 1,   TumCG↓, 18,   TumCP↓, 33,   TumCP↑, 2,   Wnt↓, 20,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 3,   AXL↓, 2,   Ca+2↑, 10,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   Cdc42↓, 1,   CDH1↑, 2,   Cofilin↓, 1,   COL1↓, 3,   COL1A1↓, 3,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 68,   EM↑, 1,   EMT↓, 84,   EpCAM↓, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 8,   Fibronectin↑, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGA5↑, 3,   ITGB1↓, 2,   ITGB1↑, 3,   ITGB3↓, 1,   LAMA5↑, 3,   LEF1↓, 3,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP2↓, 45,   MMP2↝, 1,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 45,   MMP9↝, 1,   MMPs↓, 9,   N-cadherin↓, 50,   N-cadherin↑, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 3,   Sharpin↓, 2,   Slug?, 1,   Slug↓, 42,   Smad1↓, 3,   SMAD2↓, 3,   p‑SMAD2↓, 4,   SMAD3↓, 5,   p‑SMAD3↓, 3,   p‑SMAD4↓, 1,   Snail?, 2,   Snail↓, 119,   Snail↑, 6,   TET1↑, 1,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 48,   TumCI↑, 1,   TumCMig↓, 42,   TumMeta↓, 31,   Twist↓, 27,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 8,   Vim?, 1,   Vim↓, 71,   Vim↑, 3,   vinculin↓, 1,   Zeb1↓, 25,   Zeb1↑, 4,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 35,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   NO↓, 1,   NO↝, 1,   VCAM-1↓, 3,   VEGF↓, 27,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   GLUT1↓, 2,   MMP↓, 27,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 10,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 4,   IL2↑, 2,   IL4↓, 1,   IL6↓, 17,   IL8↓, 4,   Imm↑, 2,   Inflam↓, 7,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 33,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 1,   p50↓, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 5,   RAGE↓, 1,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α∅, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 3,   AR↑, 1,   ER-α36↓, 1,   PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 30,   CompStab↑, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose↝, 11,   Dose∅, 3,   eff↓, 6,   eff↑, 15,   eff↝, 1,   Half-Life↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 10,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 28,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 3,   AR↑, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 17,   LDH↓, 2,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cachexia↓, 2,   cardioP↑, 3,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 3,   Risk↓, 5,   Symptoms∅, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 4,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Catalase↑, 5,   DPPH↓, 1,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 4,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 6,   Prx↑, 1,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 4,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   DGAT1↓, 1,   FASN↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Casp3?, 1,   Casp3↓, 3,   Cyt‑c↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   mTOR↑, 2,   PI3K↑, 2,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   RUNX2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   F-actin↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   Snail↑, 1,   TregCell↑, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↓, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   NeuroI↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 1,   CYP2E1↓, 1,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   creat↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 3,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 6,   Obesity↓, 1,   PDE4↓, 1,   toxicity↓, 7,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiViral↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 108

Scientific Paper Hit Count for: Snail, SNAI1, Snail Family Transcriptional Repressor 1
9 Sulforaphane (mainly Broccoli)
7 Resveratrol
7 Quercetin
6 EGCG (Epigallocatechin Gallate)
6 Honokiol
5 Apigenin (mainly Parsley)
4 Ellagic acid
4 Luteolin
3 Boron
3 Curcumin
3 Cyclopamine
3 Eugenol
3 Fisetin
3 HydroxyTyrosol
3 Matrine
3 Urolithin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Benzyl isothiocyanate
2 Chrysin
2 Ginkgetin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Kaempferol
2 Piperine
2 Pterostilbene
1 1,8-Cineole
1 Astragalus
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cisplatin
1 Artemisinin
1 Baicalin
1 Betulinic acid
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Chlorogenic acid
1 Citric Acid
1 Diindolylmethane
1 Genistein (soy isoflavone)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 Isorhamnetin
1 Allyl isothiocyanate
1 Juglone
1 L-Theanine
1 Magnolol
1 5-fluorouracil
1 mebendazole
1 Metformin
1 Melatonin
1 Morin
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Propranolol
1 isoflavones
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Taurine
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:376  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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