CycB/CCNB1 Cancer Research Results

CycB/CCNB1, Cyclin B: Click to Expand ⟱
Source:
Type:
When cyclin B levels are elevated, cells can enter M phase prematurely and strict control over cell division is lost, which is favorable for cancer development.
Cyclin B is a regulatory protein that plays a crucial role in cell cycle progression, particularly in the transition from the G2 phase to mitosis. Its expression levels can significantly impact cancer progression and patient prognosis.
Cyclin B expression is often elevated in various cancers and is generally associated with poor prognosis.
Cyclin B levels:
-Accumulate during S and G2
-Peak at mitotic entry
-Are rapidly destroyed at metaphase–anaphase transition via the APC/C ubiquitin ligase


Scientific Papers found: Click to Expand⟱
9226- AITC,  Cisplatin,    Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo
- vitro+vivo, Var, NA
ChemoSen↑, Apoptosis↑, Bcl-2↓, survivin↓, TumCG↓, toxicity↓, TumCCA↑, β-Tubulin↓, CDC2↓, CycB/CCNB1↓, CDC25↓,
9235- AITC,    Anticancer Activity, Mechanism, and Delivery of Allyl Isothiocyanate
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCCA↑, CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, DNAdam↑, p‑Akt↓, p‑mTOR↓, Casp3↑, Casp9↑, ROS↑, MMP↓, selectivity↑, TumAuto↑, Beclin-1/ATG6↑, HATs↓, HDAC↓, HMTs↓, p‑ERK↑, P21↑, CDC25↓, CDK1↓, FasL↑, TRAIL↑, MAPK↑, ATF6↑, GRP94↑, GRP78/BiP↑, Cal1↑, cal2↑, CHOP/DDIT3↑, BAX↑, Endoglin↑, AIF↑, APAF1↑, Cyt‑c↑, TIMP1↑, GSTs↑, GGT/CD224↑, NRF2↓, BioAv↓, BioAv↑, Risk↓,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
251- AL,    Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB/CCNB1↓, HH↓, Smo↓, Gli1↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, Var, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB/CCNB1↓, CDK1↓, P21↑, PCNA↝, HDAC↓, TumCP↓, TumCCA↑, ac‑H3↑, TumW↓, TumVol↓,
173- Api,    Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
- in-vitro, Colon, HCT116
CycB/CCNB1↓, cDC2↓, CDC25↓, P53↑, P21↑, cl‑PARP↑, proCasp8↓, proCasp9↓, proCasp3↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP/DDIT3↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
4823- ASTX,    Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest
- in-vitro, ESCC, NA
RadioS↑, Apoptosis↑, TumCCA↑, Bcl-2↓, CycB/CCNB1↓, CDC2↓, BAX↑,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
5498- Ba,    Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis
- in-vitro, Lung, H460
12LOX↓, Dose↝, TumCCA↑, CDK1↓, CycB/CCNB1↓, Apoptosis↑, Bcl-2↓, P53↑, BAX↑, TumCP↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,
9210- BITC,    Potential mechanisms of benzyl isothiocyanate suppression of invasion and angiogenesis by the U87MG human glioma cell line
- vitro+vivo, GBM, U87MG
TumCI↓, angioG↓, TumCCA↑, CycB/CCNB1↓, P21↓, MMP2↓, MMP9↓, CD44↓, CXCR4↓, Telomerase↓, PKCδ↓,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
9161- BITC,    Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, NA, MCF10
TumCG↓, TumCCA↑, Apoptosis↑, selectivity↑, CycB/CCNB1↓, CDK1↓, CDC25↓, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, Cyt‑c↑, ROS?, cl‑Casp9↑, cl‑Casp8↑, cl‑Casp3↑,
6067- CHL,    Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CycB/CCNB1↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6334- Cro,  Eug,  Rad,    Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro
- in-vitro, OS, NA
tumCV↓, RadioS↑, TumCCA↑, BAX↑, Casp3↑, Bcl-2↓, cycA1/CCNA1↓, CycB/CCNB1↓,
6189- Cuc,    Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, Cyt‑c↑, STAT3↓, Casp3↑, Casp9↑, MMP↓,
6190- Cuc,    Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells
- in-vitro, Colon, SW480
ROS↑, TumCCA↑, Apoptosis↑, CycB/CCNB1↓, CDC25↓, Casp↓, eff↓,
6184- Cuc,    Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
- vitro+vivo, PC, NA
TumCG↓, TumCCA↑, Apoptosis↑, JAK2↓, STAT3↓, STAT5↓, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, Bcl-xL↓, ChemoSen↑, TumVol↓, toxicity↓,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
118- CUR,    Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB/CCNB1↓, MDM2↓, eff↓, eIF2α↑, ATF4↑, CHOP/DDIT3↑, ER Stress↑, TumCCA↑,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
- Review, CardioV, NA
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,
8851- DIM,    3,3’-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs
- Review, Var, NA
Apoptosis↑, NF-kB↓, Akt↓, Wnt↓, PI3K↓, mTOR↓, PSA↓, Let-7↓, miR-34a↓, EZH2↓, NOTCH1↓, AR↓, E-cadherin↑, Zeb1↓, Vim↓, Slug↓, EMT↓, MTA2↓, NF-kB↓, IRAK1↓, EGFR↓, SOX4↓, FOXM1↓, p27/CDKN1B↓, AhR↓, EZH2↓, Wnt↓, PUMA↓, AEG1↑, ROS↑, PPARα↑, CycB/CCNB1↑,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6276- DL,  Tam,    Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, Apoptosis↑,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB/CCNB1↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
1331- EMD,    Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
- in-vitro, NPC, NA
TumCCA↑, CycB/CCNB1↑, DNAdam↑, Casp3↑, cl‑PARP↑, MMP↓, Ca+2↑, ROS↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6386- Eug,    A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, Inflam↝, TumCI↓, TumMeta↓, cycD1/CCND1↓, CycB/CCNB1↓, PCNA↓, NF-kB↓, Bcl-2↓, BAX↑, AIF↑, P21↑, P53↑, ChemoSen↑,
6856- FBZ,    Fenbendazole Suppresses Growth and Induces Apoptosis of Actively Growing H4IIE Hepatocellular Carcinoma Cells via p21-Mediated Cell-Cycle Arrest
- in-vitro, Liver, H4IIE
TumCCA↑, P21↑, cycD1/CCND1↓, CycB/CCNB1↓, GlucoseCon∅, lactateProd∅, ROS∅, selectivity↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp/ABCB1∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, Synergy↑, Dose↝, TumCG↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,

Showing Research Papers: 1 to 50 of 111
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 111

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE/EpRE↑, 1,   Catalase↓, 1,   Fenton↑, 1,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 9,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 2,   HO-1↓, 1,   HO-1↑, 3,   Iron↓, 1,   Iron↑, 1,   i-Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 6,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 7,   NRF2↑, 5,   ROS?, 1,   ROS↓, 10,   ROS↑, 57,   ROS⇅, 2,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 11,   CDC2↑, 1,   CDC25↓, 20,   CDC25↑, 1,   CDC25↝, 1,   compI↓, 1,   compIII↓, 2,   compV↓, 1,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 3,   OXPHOS↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   ALDOA↓, 1,   AMPK↓, 1,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 2,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   ENO1↓, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   Glycolysis↓, 5,   GSK‐3β↓, 3,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   H2S↑, 1,   HK1↓, 1,   HK2↓, 5,   lactateProd↓, 3,   lactateProd∅, 1,   LDHA↓, 3,   MCT4↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 3,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 2,   p‑S6↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 7,   Apoptosis↓, 2,   Apoptosis↑, 65,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 2,   BAX↓, 2,   BAX↑, 44,   Bax:Bcl2↑, 5,   Bcl-2↓, 47,   Bcl-2↑, 2,   Bcl-xL↓, 15,   BID↑, 1,   BIM↑, 1,   BNIP3↑, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 5,   Casp10↑, 2,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 40,   cl‑Casp3↑, 12,   proCasp3↓, 1,   Casp7↑, 9,   Casp8↑, 13,   cl‑Casp8↑, 4,   proCasp8↓, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 34,   cl‑Casp9↑, 4,   proCasp9↓, 2,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 24,   Diablo↑, 2,   DR5↓, 1,   DR5↑, 10,   FADD↑, 3,   Fas↑, 9,   FasL↑, 6,   Ferroptosis↑, 3,   HEY1↓, 1,   IAP1↓, 2,   iNOS↓, 5,   Mcl-1↓, 7,   MDM2↓, 9,   MOMP↑, 2,   NAIP↓, 1,   p38↑, 6,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↓, 1,   PUMA↑, 3,   survivin↓, 16,   TRAIL↑, 2,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 5,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 38,   Akt↑, 2,   p‑Akt↓, 13,   AKT1↓, 1,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↓, 1,   EGFR↓, 6,   p‑EGFR↓, 1,   ERK↓, 13,   ERK↑, 2,   p‑ERK↓, 7,   p‑ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 3,   p‑IKKα↓, 1,   IκB↑, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 7,   p‑JNK↓, 1,   p‑JNK↑, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 10,   MAPK↑, 5,   p‑MAPK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   p70S6↑, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 32,   PI3K↑, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 6,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 3,   Raf↓, 2,   RAS↓, 4,   RSK2/RPS6KA3/p90RSK2↓, 1,   Sp1/3/4↓, 3,   STAT↓, 1,   STAT3↓, 20,   STAT3↑, 1,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↑, 5,   CBP↓, 1,   p‑cJun↑, 1,   cMyc↓, 13,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMTs↓, 1,   EZH2↓, 4,   FOXM1↓, 5,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   H3↓, 3,   H3↑, 1,   p‑H3↑, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC10↓, 1,   HDAC6↓, 1,   HMTs↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   MTA2↓, 1,   MYCN↓, 1,   OCT4↓, 2,   other↓, 1,   other↝, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 10,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 14,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   GRP94↑, 1,   HSP70/HSPA5↓, 3,   HSP90↓, 5,   PERK↑, 2,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 2,   LC3II↑, 3,   p62↑, 2,   RUBCN↓, 1,   TumAuto↑, 10,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DFF45↓, 1,   DNAdam↑, 13,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 3,   P53↓, 2,   P53↑, 37,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↓, 5,   PARP↑, 10,   cl‑PARP↑, 22,   PCNA↓, 11,   PCNA↝, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 3,   TOP2↑, 1,   XRCC1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 38,   CDK1↑, 2,   CDK1↝, 1,   p‑CDK1↓, 1,   p‑CDK1↑, 1,   CDK2↓, 22,   CDK2↑, 1,   p‑CDK2↓, 1,   CDK4↓, 21,   CDK4/6↓, 1,   CDK6↓, 4,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 3,   Cyc↓, 1,   cycA1/CCNA1↓, 19,   cycA1/CCNA1↑, 3,   CycB/CCNB1↓, 93,   CycB/CCNB1↑, 16,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 30,   cycD1/CCND1↑, 2,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 3,   Ki-67↓, 6,   mitA↑, 1,   P21↓, 3,   P21↑, 41,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 13,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 3,   TumCCA↑, 91,   WEE1↑, 3,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH1A1↓, 1,   BMI1↓, 1,   CD133↓, 2,   cFos↓, 2,   CSCs?, 1,   CSCs↓, 9,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 6,   Let-7↓, 1,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 5,   NOTCH1↓, 3,   NOTCH1↑, 1,   p300↓, 1,   Shh↓, 3,   Smo↓, 1,   TAZ↓, 1,   TumCG↓, 22,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 48,   TumCP↑, 1,   Wnt↓, 9,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   AP-1↓, 4,   Ca+2↑, 8,   i-Ca+2↑, 1,   Cal1↑, 1,   cal2↑, 1,   Cdc42↑, 1,   E-cadherin↑, 13,   E-cadherin↝, 1,   EMT↓, 16,   EMT↑, 1,   FAK↓, 4,   p‑FAK↓, 2,   KRAS↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 19,   MMP3↓, 4,   MMP7↓, 1,   MMP9↓, 19,   MMP9↑, 2,   MMPs↓, 9,   N-cadherin↓, 9,   N-cadherin↝, 1,   pax↓, 1,   PDGF↓, 2,   Rho↓, 2,   ROCK1↓, 3,   Slug↓, 5,   Snail↓, 6,   TGF-β↓, 5,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 3,   TSC1↑, 1,   TSP-1↑, 1,   TumCI↓, 18,   TumCMig↓, 13,   TumMeta↓, 12,   TumMeta↑, 1,   Twist↓, 4,   uPA↓, 6,   uPAR↓, 2,   Vim↓, 11,   Zeb1↓, 3,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 11,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN2↓, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 29,   TRPV1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 1,   CD44↓, 3,   cDC2↓, 7,   p‑cDC2↓, 1,   COX2/PTGS2↓, 19,   COX2/PTGS2↑, 1,   CXCR4↓, 6,   Eos↑, 1,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 2,   IL12↓, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 2,   IL2↑, 1,   IL6↓, 12,   IL8↓, 4,   Imm↑, 4,   Inflam↓, 7,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   mPGES-1↓, 1,   Neut↑, 1,   NF-kB↓, 33,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   p50↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 4,   PSA↓, 3,   SOCS-3↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 12,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 5,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↑, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 8,   BioAv↑, 12,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 32,   CompStab↑, 1,   CompStab↝, 1,   Dose?, 1,   Dose↝, 5,   Dose∅, 1,   eff↓, 19,   eff↑, 12,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 4,   Half-Life↑, 1,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 4,   P-gp/ABCB1∅, 1,   RadioS↑, 13,   selectivity↑, 21,   Synergy↑, 20,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 5,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 6,   p‑EGFR↓, 1,   EZH2↓, 4,   FOXM1↓, 5,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 12,   KRAS↓, 1,   LDH↑, 1,   PD-L1↓, 3,   PSA↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   AntiTum↑, 4,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 4,   ChemoSideEff↓, 1,   hepatoP↑, 1,   OS↑, 1,   radioP↑, 4,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 6,   TumVol↓, 6,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 577

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 14,   Catalase↑, 6,   GPx↑, 5,   GPx4↑, 1,   GSH↑, 8,   GSR↑, 1,   GSTs↑, 4,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 8,   MDA↓, 4,   MPO↓, 2,   Nrf1↑, 1,   NRF2↑, 7,   Prx↑, 1,   RNS↓, 1,   ROS↓, 21,   ROS↑, 1,   SOD↓, 1,   SOD↑, 7,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ACSL4↓, 1,   ALAT↓, 1,   AMPK↑, 3,   ATP↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3?, 1,   Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   JAK↓, 1,   JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   FOXO3↑, 1,   other↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   TregCell↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 2,   GastroP↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 4,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 14,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 3,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 9,   BioAv↝, 8,   Dose↝, 1,   eff↑, 1,   Half-Life↑, 1,   Half-Life↝, 3,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 2,   creat↓, 1,   IL6↓, 2,   IRes↝, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 5,   AntiTum↓, 2,   cardioP↑, 6,   chemoP↑, 3,   cognitive↑, 1,   diuretic↑, 1,   hepatoP↑, 9,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 13,   Obesity↓, 4,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Stroke↓, 1,   toxicity↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 3,  
Total Targets: 141

Scientific Paper Hit Count for: CycB/CCNB1, Cyclin B
10 Quercetin
4 Propolis -bee glue
4 Licochalcone A
4 Sulforaphane (mainly Broccoli)
3 Allyl isothiocyanate
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Benzyl isothiocyanate
3 Eugenol
3 Cucurbitacin
3 Curcumin
3 Emodin
3 Luteolin
3 Magnolol
3 Plumbagin
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Betulinic acid
2 Chrysin
2 D-limonene
2 Fenbendazole
2 Formononetin
2 Garcinol
2 Isoliquiritigenin
2 Isorhamnetin
2 Kaempferol
2 lambertianic acid
2 Magnetic Fields
2 Morin
2 doxorubicin
2 Silymarin (Milk Thistle) silibinin
1 Cisplatin
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Artemisinin
1 Astaxanthin
1 Aloe anthraquinones
1 Berberine
1 Biochanin A
1 Bufalin/Huachansu
1 Phenethyl isothiocyanate
1 Isothiocyanates
1 Chlorophyllin
1 Cinnamon
1 Crocetin
1 Radiotherapy/Radiation
1 Diindolylmethane
1 tamoxifen
1 Fisetin
1 Genistein (soy isoflavone)
1 isoflavones
1 isoorientin
1 Juglone
1 Laetrile B17 Amygdalin
1 Lapachol
1 SDG/lignans
1 Lycopene
1 Mangiferin
1 Melatonin
1 Phenylbutyrate
1 Piperlongumine
1 Resveratrol
1 Rutin
1 buckwheat sprouts
1 Thymoquinone
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:379  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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