TNFR 1 Cancer Research Results

TNFR 1, Tumor necrosis factor receptor 1,: Click to Expand ⟱
Source:
Type:
TNFR-1 is an important member of the death receptor family that shares the capability of inducing apoptotic cell death.

TNFR1 (p55): Often expressed ubiquitously, TNFR1 can mediate both apoptotic and survival signals. In some cancers, its upregulation has been associated with increased inflammatory signaling and may contribute to tumor progression through NF-κB activation.
Scientific Papers found: Click to Expand⟱
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
6673- Deg,    Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion
- in-vitro, Var, NA
NF-kB↓, IKKα↓, TNFR 1↓, TumCP↓, TumCI↓,
8715- MeJa,    Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells
- in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, memfluid↓, TNFR 1↑, MAPK↑, Casp8↑, MMP↓, Apoptosis↑, p38↑, ERK↑, Casp3↑,
8952- mushLions,    Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation
- vitro+vivo, CRC, DLD1
TNFR 1↑, Fas↑, FasL↑, Casp↑, Bcl-2↓, Bcl-xL↓, tumCV↓, selectivity↑, MMP2↓, MMP9↓, Apoptosis↑, Dose↝,
8961- mushLions,    A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation
- in-vivo, CRC, NA
Apoptosis↑, TRAIL↑, TNFR 1↑, DR5↑, p‑Akt↓, p‑ERK↓, Hif1a↓, PCNA↓, NF-kB↓, TumCI↓, TumCMig↓, TumCP↓,
48- QC,    Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells
- in-vitro, NSCLC, H460
TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↓, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   ROS↑, 3,   ROS⇅, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↑, 6,   BAX↑, 2,   Bcl-2↓, 3,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp↑, 2,   Casp10↑, 2,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 2,   CellShr↑, 1,   Cyt‑c↑, 2,   Diablo↑, 1,   DR5↑, 2,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   ICAD↓, 1,   iNOS↓, 1,   MOMP↑, 1,   p38↑, 1,   survivin↓, 2,   TNFR 1↓, 1,   TNFR 1↑, 7,   TRAIL↑, 1,   TRAILR↑, 2,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑Akt↓, 1,   EGFR↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IKKα↓, 3,   MAPK↑, 1,   mTOR↓, 2,   PI3K↓, 2,   Sp1/3/4↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   other↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 2,   DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

ChrCon↑, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   NOTCH1↓, 1,   TumCG↓, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   COL1↓, 2,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibronectin↓, 1,   LEF1↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 1,   Slug↓, 2,   Snail↓, 2,   TGF-β↓, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 2,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

memfluid↓, 1,   MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   DR4↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   RAGE↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 1,   TRADD↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Dose↝, 2,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 1,   Synergy?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 2,   RenoP↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 125

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NeuroI↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 20

Scientific Paper Hit Count for: TNFR 1, Tumor necrosis factor receptor 1,
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Quercetin
1 Boswellia (frankincense)
1 Deguelin
1 Methyl Jasmonate
1 Spirulina(Arthrospira/Limnospira)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:381  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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