Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
6463- 1,8-Cin,    Antitumor effect of 1, 8-cineole against colon cancer
- vitro+vivo, Colon, HCT116
TumCP↓, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3↑, TumVol↓,
7857- 3BP,    A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS Cells
- in-vitro, NA, AGS
tumCV↓, selectivity↑, *toxicity↓, Apoptosis↑, ROS↑, eff↓, TumCCA↑, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, TumCMig↓, Twist↓, N-cadherin↑, β-catenin/ZEB1↓, E-cadherin↑,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
1335- AG,    Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
p‑PI3K↓, p‑GS3Kβ↓, p‑Akt↓, p‑mTOR↓,
1338- AG,    The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method
- in-vitro, BC, NA
TumCI↓, Apoptosis↑, Symptoms↓, PIK3CA↓, Akt↓, Bcl-2↓,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5977- AgNPs,  CDT,    Silver Nitroprusside as an Efficient Chemodynamic Therapeutic Agent and a Peroxynitrite nanogenerator for Targeted Cancer Therapy
- in-vivo, Ovarian, A2780S - NA, Ovarian, SKOV3
Fenton↑, ROS↑, eff↑, angioG↓, p‑Akt↓, EPR↑, selectivity↑, selectivity↑, eff↑, Cyt‑c↑, HO-1↑,
4426- AgNPs,    Antiangiogenic properties of silver nanoparticles
- Study, NA, NA
angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,
4549- AgNPs,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
334- AgNPs,    Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53
- in-vitro, Colon, HCT116
Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,
324- AgNPs,  CPT,    Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
- in-vitro, Cerv, HeLa
ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,
309- AgNPs,    Interference of silver, gold, and iron oxide nanoparticles on epidermal growth factor signal transduction in epithelial cells
- in-vitro, NA, A431
ROS↑, Akt↓, p‑ERK↓,
377- AgNPs,    Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis
- in-vitro, BC, SkBr3
ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,
2288- AgNPs,    Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
- Review, Var, NA
*ROS↑, Akt↓, ERK↓, DNAdam↑, Ca+2↑, ROS↑, MMP↓, Cyt‑c↑, TumCCA↑, DNAdam↑, Apoptosis↑, P53↑, p‑ERK↑, ER Stress↑, cl‑ATF6↑, GRP78/BiP↑, CHOP/DDIT3↑, UPR↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
247- AL,    Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MMP2↓, MMP9↓, TIMP1↑, TIMP2↑, p‑Akt↓, PI3K/Akt↓,
256- AL,  doxoR,    Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
NRF2↓, HO-1↓, p‑Akt↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3434- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, PI3K↓, p‑Akt↓, p‑P70S6K↓, mTOR↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, LDHA↓, Glycolysis↓, ChemoSen↑,
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF7
ChemoSen↑, PI3K↓, Akt↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, Glycolysis↓, CSCs↓, IGF-1R↓, Furin↓, RadioS↑,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *eff↑, *memory↑, *motorD↑, *GutMicro↑,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
295- ALA,    α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
ITGB1↓, TumCMig↓, ERK↓, Akt↓,
259- ALA,    Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
- in-vitro, Liver, HepG2 - in-vitro, Liver, FaO
Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,
261- ALA,    The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells
- in-vitro, BC, MCF7
ROS↓, Akt↓, p27/CDKN1B↑, Bax:Bcl2↑,
258- ALA,    Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells
- in-vitro, BC, MDA-MB-231
TumCG↓, p‑Akt↓, Akt↓, HER2/EBBR2↓, Bcl-2↓, BAX↑, Casp3↑,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
4283- ALC,    Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice
- in-vivo, NA, NA
*BDNF↑, *p‑Akt↑, *PI3K↑,
6597- Anamu,    Dibenzyl trisulfide inhibits proliferation and induces apoptosis of HN30 cells via Akt/ p53 signaling pathway
- in-vitro, HNSCC, HN30 - in-vitro, Tong, SCC25
tumCV↓, Apoptosis↑, MMP↓, cl‑Casp3↑, Bcl-2↓, p‑Akt↓, p‑P53↑, TumCP↓,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,
6393- ANE,    Anethole in cancer therapy: Mechanisms, synergistic potential, and clinical challenges
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCCA↑, TumCP↓, angioG↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, Casp↓, ChemoSen↑,
6399- ANE,    Anethole attenuates lung cancer progression by regulating the proliferation and apoptosis through AKT and STAT3 signaling
- vitro+vivo, NSCLC, A549
TumCP↓, TumCG↓, Apoptosis↑, DNAdam↑, Casp3↑, PI3K↓, Akt↓, STAT3↓, Ki-67↓, cl‑Casp3↑,
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↓, *PI3K↑, *Akt↑, *mTOR↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
6405- ANE,    Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
BAX↑, Bcl-2↓, PI3K↓, Akt↓, TumCP↓, Apoptosis↑,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
1008- Api,    Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
577- Api,  PacT,    Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
p‑Akt↓, Bcl-xL↓, Bcl-2↓, AXL↓, Tyro3↓,

Showing Research Papers: 1 to 50 of 907
Page 1 of 19 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 907

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   ACE/ACE1↓, 1,   AKR1B10↓, 1,   APOE4↑, 1,   ASAP2↓, 1,   ATG13↑, 1,   ATG16L1↑, 1,   ATGL/PNPLA2↓, 1,   BMP7/OP1↓, 3,   CCN1/CYR61↓, 1,   CD47↓, 1,   CDK7↓, 1,   i-Cer↑, 1,   ChrCon↑, 1,   compII↓, 1,   compV↓, 1,   CTSK↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   CXCL16↓, 1,   DDIT4↑, 1,   DHODH↓, 1,   ERCC3↑, 1,   FEN1↓, 1,   FFA/NEFA↓, 1,   FGFR4/CD334↓, 1,   HES1↓, 2,   HLA-I/II↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   HSP60/HSPD1↓, 2,   IGF-2R↑, 2,   ILK↓, 1,   Ingr↝, 3,   IP6K1↓, 1,   IQGAP3↓, 1,   IRes↓, 1,   LIMK1↓, 1,   LRIG1↑, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-124-3p↓, 1,   miR-149↑, 1,   miR-224↓, 2,   miR-339-5p↝, 1,   miR-375↝, 1,   miR-422a↑, 2,   miR-590-3p↑, 1,   MMP16↓, 3,   MTA1↓, 1,   MYCN↓, 1,   NA↓, 1,   NA↑, 2,   NA?, 1,   NOD1↓, 1,   O-Glc↓, 1,   OGFr↑, 1,   PA↑, 1,   PDE3B↓, 1,   PFS↑, 1,   PGI2↓, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   PTN↓, 1,   Rictor↓, 1,   RUBCN↓, 1,   SERPINH1/HSP47↓, 1,   SUV39H↓, 2,   TF-Ag↓, 1,   TFE3↑, 2,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRAF2↑, 1,   ULK1/ATG1↑, 1,   WDR72↓, 1,   WEE1↑, 2,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 13,   antiOx⇅, 2,   ARE↓, 1,   ATF3↑, 4,   Catalase↓, 14,   Catalase↑, 4,   compI↓, 4,   Copper↓, 1,   CYP1A1↓, 4,   CYP1A1↑, 3,   CYP2E1↑, 1,   Fenton↑, 4,   Ferroptosis↑, 17,   frataxin↑, 1,   GPx↓, 5,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 9,   GSH↓, 37,   GSH↑, 9,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 2,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 3,   H2O2↑, 2,   HK1↓, 1,   HO-1↓, 13,   HO-1↑, 28,   HO-2↓, 1,   hyperG↓, 1,   ICD↑, 4,   Iron↓, 2,   Iron↑, 5,   Iron↝, 1,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 8,   lipid-P↑, 17,   MAD↓, 1,   MDA↓, 2,   MDA↑, 13,   MFN2↑, 1,   MPO↓, 1,   NADH↓, 2,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 4,   NRF2↓, 29,   NRF2↑, 25,   NRF2↝, 4,   p‑NRF2↓, 1,   OSI↑, 1,   OXPHOS↓, 5,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PAO↑, 1,   PARK2↑, 2,   Prx↓, 1,   Prx4↑, 1,   PYCR1↓, 2,   ROS?, 1,   ROS↓, 40,   ROS↑, 322,   ROS⇅, 9,   ROS↝, 3,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 3,   SIRT3↑, 2,   SOD?, 1,   SOD↓, 15,   SOD↑, 10,   mt-SOD↑, 1,   SOD1↓, 3,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 4,   TAC↓, 2,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR1↓, 4,   VDAC1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 3,   IronCh∅, 1,   KLF5↓, 1,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 12,   ATP↓, 43,   mt-ATP↓, 1,   BOK↑, 2,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 11,   compIII↓, 1,   EGF↓, 10,   EGF↑, 1,   ETC↓, 5,   FGFR1↓, 4,   Insulin↓, 3,   MEK↓, 14,   p‑MEK↓, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK4↓, 2,   MKK7↓, 1,   MMP↓, 155,   MMP↑, 3,   MPT↑, 8,   mtDam↓, 1,   mtDam↑, 30,   OCR↓, 8,   OCR↑, 1,   p‑p42↓, 1,   PGC-1α↑, 1,   PINK1↑, 2,   Raf↓, 12,   e-Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 45,   XIAP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 5,   ACC↓, 2,   ACC↑, 4,   p‑ACC↑, 2,   Acetyl-CoA↓, 1,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 1,   adiP↑, 1,   AKT1↓, 3,   ALAT↓, 6,   ALDOA↓, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 42,   p‑AMPK↑, 3,   ATG7↑, 4,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   Cav1↓, 1,   CholSyn↓, 1,   cMyc↓, 55,   cMyc↑, 1,   p‑cMyc↑, 1,   CYP3A4↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ECAR∅, 1,   ENO1↓, 2,   p‑ENO1↓, 1,   FABP4↓, 1,   FABP4↑, 1,   FASN↓, 10,   FASN↑, 1,   FBPase↑, 1,   FGF21↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 2,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↓, 25,   GlucoseCon↑, 2,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 65,   Glycolysis↑, 1,   p‑GS3Kβ↓, 1,   H2S↑, 1,   HK2?, 1,   HK2↓, 38,   HK2↑, 1,   HMG-CoA↓, 1,   HSD17B4↓, 1,   lactateProd↓, 24,   lactateProd↑, 3,   LDH↓, 7,   LDH↑, 2,   i-LDH↓, 1,   LDHA↓, 18,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MCU↓, 1,   NADPH↓, 4,   NADPH↑, 3,   p‑PCK1↓, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 20,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 4,   PFK1↓, 3,   PFK2↓, 2,   PFKP↓, 1,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 3,   PIK3CA↓, 2,   p‑PIK3R1↓, 1,   PKM2↓, 27,   PKM2↑, 1,   PKM2:PKM1↓, 1,   POLD1↓, 1,   polyA↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 2,   PPARγ↑, 10,   PPARγ↝, 1,   Pyruv↓, 2,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 3,   S6K↓, 1,   p‑S6K↓, 3,   SCD1↓, 3,   SIRT1↓, 8,   SIRT1↑, 9,   SIRT2↓, 2,   SREBF2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   SSAT↑, 1,   STK11/LKB1↑, 2,   p‑STK11/LKB1↑, 1,   TCA↓, 3,   TCA↑, 1,   TS↓, 3,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1,   AhR↓, 1,   AhR↑, 1,   Akt↓, 595,   Akt↑, 28,   Akt↝, 3,   Akt∅, 1,   p‑Akt↓, 209,   p‑Akt↑, 8,   APAF1↑, 12,   Apoptosis?, 2,   Apoptosis↓, 7,   Apoptosis↑, 355,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASK1↑, 2,   ATF2↓, 1,   BAD↓, 7,   BAD↑, 23,   p‑BAD↓, 2,   Bak↓, 1,   Bak↑, 15,   BAX↓, 4,   BAX↑, 186,   BAX↝, 4,   Bax:Bcl2↑, 49,   Bcl-2↓, 206,   Bcl-2↑, 6,   Bcl-2↝, 3,   Bcl-2∅, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 48,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 11,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 11,   BMP2↓, 1,   Casp↓, 2,   Casp↑, 47,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 3,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 3,   Casp3↓, 4,   Casp3↑, 218,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 50,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   proCasp3↑, 4,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 18,   cl‑Casp7↑, 5,   Casp8↓, 3,   Casp8↑, 48,   Casp8∅, 2,   cl‑Casp8↑, 8,   proCasp8↑, 3,   pro‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 121,   p‑Casp9↑, 1,   cl‑Casp9↑, 23,   proCasp9↓, 1,   proCasp9↑, 3,   CBP↓, 3,   cFLIP↓, 9,   Chk2↓, 2,   p‑Chk2↑, 1,   CK2↓, 7,   Cyt‑c↓, 1,   Cyt‑c↑, 124,   Cyt‑c↝, 2,   Diablo↑, 11,   DR4↑, 10,   DR5↓, 1,   DR5↑, 40,   FADD↑, 5,   Fap1↓, 1,   Fas↓, 3,   Fas↑, 27,   FasL↓, 1,   FasL↑, 8,   FasL⇅, 1,   Ferroptosis↑, 17,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDMD↑, 1,   GSDME↑, 2,   HEY1↓, 2,   HGF/c-Met↓, 3,   Hippo↓, 2,   Hippo↝, 1,   hTERT/TERT↓, 14,   IAP1↓, 11,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 19,   JNK↓, 10,   JNK↑, 33,   JNK↝, 1,   p‑JNK↓, 5,   p‑JNK↑, 7,   JWA↑, 1,   MAPK?, 1,   MAPK↓, 66,   MAPK↑, 22,   MAPK↝, 2,   p‑MAPK↓, 1,   p‑MAPK↑, 3,   Mcl-1?, 1,   Mcl-1↓, 46,   p‑Mcl-1↓, 1,   MCT1↓, 2,   MDM2↓, 14,   MDM2↑, 1,   p‑MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   MLKL↑, 2,   MOMP↑, 2,   Myc↓, 7,   NAIP↓, 2,   Necroptosis↑, 5,   necrosis↑, 3,   NICD↓, 1,   NOXA↑, 4,   oncosis↑, 1,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 47,   p38↓, 12,   p38↑, 31,   p‑p38↓, 3,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   Proteasome↓, 3,   PUMA↑, 6,   Pyro↑, 7,   RIP1↓, 3,   RIP1↑, 1,   p‑RIP1↑, 1,   survivin↓, 72,   Telomerase↓, 13,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 2,   TRPV1↑, 2,   TRPV1↝, 1,   TumCD↑, 27,   YAP/TEAD↓, 9,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 3,   CaMKII ↓, 3,   CaMKII ↑, 1,   cSrc↓, 4,   EF-1α↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 22,   p‑HER2/EBBR2↓, 1,   p70S6↓, 5,   p‑p70S6↓, 3,   p‑p70S6↑, 1,   RET↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 15,   TSC2↑, 5,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↓, 1,   BowelM↑, 1,   ChrMod↑, 1,   cJun↓, 10,   cJun↑, 3,   p‑cJun↑, 1,   EZH2↓, 6,   H3↓, 3,   H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 7,   HATs↑, 1,   miR-205↑, 1,   miR-21↓, 8,   miR-21↑, 1,   miR-218↑, 1,   miR-27a-3p↓, 1,   other?, 1,   other↓, 6,   other↑, 2,   other↝, 14,   PCAF↓, 2,   PhotoS↑, 1,   pRB↓, 4,   pRB↑, 1,   p‑pRB↓, 6,   TLE1↓, 1,   tumCV?, 3,   tumCV↓, 97,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 30,   eIF2α↓, 3,   eIF2α↑, 8,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 58,   ERStress↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 7,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSP90↓, 30,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 9,   p‑PERK↑, 1,   UPR↑, 13,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG3↑, 5,   ATG5↑, 10,   Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 26,   BNIP3↑, 3,   BNIP3↝, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↑, 4,   LC3I↓, 1,   LC3II↓, 3,   LC3II↑, 24,   LC3s↑, 2,   MitoP↑, 1,   p62↓, 10,   p62↑, 7,   SESN2↑, 3,   TumAuto↓, 1,   TumAuto↑, 89,   TumAuto⇅, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 3,   p‑CHK1↑, 2,   CYP1B1↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↓, 2,   DNAdam↑, 84,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 11,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 6,   HR↓, 1,   MGMT↓, 1,   p16↑, 4,   P53?, 1,   P53↓, 5,   P53↑, 128,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 6,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   p73↑, 2,   PARP↓, 7,   PARP↑, 31,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↑, 110,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 37,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 2,   TP53↓, 1,   TP53↑, 5,   UHRF1↓, 1,   γH2AX↑, 11,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 25,   CDK1↑, 2,   p‑CDK1↓, 2,   CDK1/2/5/9↓, 1,   CDK2↓, 49,   CDK2↑, 4,   CDK4↓, 58,   CDK4↑, 4,   p‑CDK4↓, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 13,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 35,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 115,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 26,   cycE/CCNE↑, 1,   cycE1↓, 2,   E2Fs↓, 5,   E2Fs↑, 1,   mitA↓, 1,   mitA↑, 1,   p19↑, 2,   P21↓, 8,   P21↑, 87,   P21↝, 2,   PLK1↓, 1,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 3,   TAp63α↑, 1,   TFAP2A↓, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 290,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 5,   ALDH↓, 8,   ALDH1A1↓, 5,   AR-V7?, 1,   AXIN1↑, 2,   Axin2↑, 1,   CD133↓, 11,   CD133↑, 1,   CD24↓, 2,   CD34↓, 2,   CD44↓, 16,   cDC2↓, 1,   CDK8↓, 2,   cFos↓, 10,   cFos↑, 1,   CIP2A↓, 2,   cMET↓, 9,   p‑cMET↑, 2,   CSCs?, 1,   CSCs↓, 50,   CSCs↑, 1,   CTSB↓, 2,   CTSD↓, 2,   Diff↓, 2,   Diff↑, 5,   EIF4E↓, 2,   EMT↓, 123,   EMT↑, 4,   EMT↝, 1,   EP2↓, 1,   EP4/PTGER4↓, 1,   EpCAM↓, 2,   ERK↓, 108,   ERK↑, 13,   ERK∅, 1,   p‑ERK↓, 35,   p‑ERK↑, 8,   p‑ERK⇅, 1,   FGF↓, 4,   FGF↑, 1,   FGFR2↓, 1,   FOXM1↓, 6,   FOXO↑, 3,   FOXO1↓, 3,   FOXO1↑, 4,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 8,   GSK‐3β↓, 25,   GSK‐3β↑, 15,   GSK‐3β↝, 2,   p‑GSK‐3β↓, 12,   p‑GSK‐3β↑, 3,   H3K27ac↓, 1,   HDAC↓, 21,   HDAC∅, 1,   HDAC1↓, 7,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 5,   HDAC4↓, 2,   HDAC8↓, 5,   HH↓, 10,   HMGCR↓, 1,   HRAS↓, 1,   IGF-1↓, 20,   p‑IGF-1↓, 1,   IGF-1R↓, 15,   IGF-1R↑, 1,   p‑IGF-1R↓, 1,   IGF-2↓, 2,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 3,   IGFBP7↑, 1,   IGFR↓, 2,   p‑IGFR↓, 1,   Jun↓, 1,   p‑Jun↓, 1,   p‑Jun↑, 1,   Let-7↑, 2,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-125b↝, 1,   miR-34a↓, 2,   miR-34a↑, 7,   miR-429↑, 1,   mTOR↓, 224,   mTOR↑, 3,   mTOR⇅, 1,   mTOR↝, 3,   mTOR∅, 1,   p‑mTOR↓, 45,   mTORC1↓, 12,   p‑mTORC1↓, 1,   mTORC2↓, 5,   mTORC2↑, 2,   n-MYC↓, 2,   Nanog↓, 17,   Nestin↓, 4,   NOTCH↓, 24,   NOTCH1↓, 19,   NOTCH1↑, 3,   NOTCH3↓, 3,   OCT4↓, 15,   p300↓, 4,   P70S6K↓, 14,   p‑P70S6K↓, 6,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 359,   PI3K↑, 12,   PI3K↝, 4,   p‑PI3K↓, 38,   PIAS-3↑, 1,   PRKCG↑, 1,   PTCH1↓, 1,   PTEN↓, 5,   PTEN↑, 54,   PTEN↝, 1,   p‑PTEN↓, 1,   RAS↓, 18,   RAS↑, 1,   RPS6KA1↓, 1,   SCF↓, 2,   Shh↓, 10,   SHP1↑, 2,   Smo↓, 4,   SOX2↓, 15,   Src↓, 6,   Src↑, 1,   p‑Src↓, 1,   STAT↓, 10,   p‑STAT↓, 1,   STAT1↓, 1,   p‑STAT1↓, 1,   STAT3↓, 108,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 3,   STAT5↓, 2,   STAT6↓, 4,   p‑STAT6↓, 1,   TAZ↓, 1,   TCF↓, 4,   TCF↑, 1,   TCF↝, 1,   TCF-4↓, 2,   TK1↓, 1,   TOP1?, 1,   TOP1↓, 5,   TOP2↓, 6,   TOP2↑, 1,   TRPM7↓, 5,   TRPM7↑, 1,   TumCG?, 2,   TumCG↓, 131,   TumCG↑, 5,   tyrosinase↓, 2,   Wnt?, 1,   Wnt↓, 67,   Wnt↑, 2,   Wnt↝, 1,   Wnt/(β-catenin)↓, 8,  

Migration(tgid=13) ⓘ

5LO↓, 7,   AEG1↓, 1,   Akt2↓, 2,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 20,   AP-1↝, 1,   ATPase↓, 2,   AXL↓, 4,   CA↓, 3,   Ca+2↓, 6,   Ca+2↑, 34,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 6,   Cdc42↓, 1,   CDK4/6↓, 3,   CEA↓, 2,   Chl↓, 1,   Chl↑, 1,   CLDN1↓, 5,   CLDN2↓, 2,   Cofilin↓, 2,   p‑Cofilin↑, 2,   COL1↓, 2,   COL3A1↓, 1,   COL4↓, 1,   CXCL12↓, 2,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 60,   EM↑, 1,   ER-α36↓, 4,   F-actin↓, 3,   FAK↓, 26,   FAK↑, 1,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 6,   FTO↓, 1,   Furin↓, 2,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   ITGA5↓, 2,   ITGB1↓, 6,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   Ki-67↓, 44,   KLF2↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MARK4↓, 1,   MET↓, 4,   p‑MET↓, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-29b↑, 2,   miR-340↓, 2,   miR-384↑, 2,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 2,   MMP15↓, 1,   MMP17↓, 1,   MMP2↓, 129,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 12,   MMP7↓, 14,   MMP9↓, 141,   MMP9↑, 2,   MMPs↓, 44,   MUC1↑, 1,   MUC4↓, 2,   N-cadherin↓, 48,   N-cadherin↑, 1,   NCAM↑, 1,   NEDD9↓, 3,   p44↓, 1,   p‑p44↓, 2,   PAK1↓, 5,   PAK1↑, 1,   PDGF↓, 5,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 15,   PKCδ↑, 1,   Rac1↓, 3,   RAGE↓, 2,   RECK↑, 1,   Rho↓, 3,   Rho↑, 2,   Rho↝, 1,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   ROCK1↓, 5,   ROCK1↑, 1,   SDC1↑, 1,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 22,   Smad1↓, 2,   Smad1↑, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   p‑SMAD3↓, 1,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 42,   Snail↑, 1,   SOX4↓, 2,   SOX4↑, 1,   STAC2↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 22,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 14,   TIMP2↓, 4,   TIMP2↑, 8,   Treg lymp↓, 2,   TRIB3↑, 3,   TSC1↑, 2,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI↓, 140,   TumCI↑, 3,   TumCMig↓, 139,   TumCMig↑, 4,   TumCP?, 1,   TumCP↓, 270,   TumCP↑, 5,   TumMeta↓, 113,   TumMeta↑, 6,   TumPF↓, 1,   Twist↓, 32,   Twist↑, 1,   Tyro3↓, 2,   uPA↓, 24,   uPAR↓, 2,   VCAM-1↓, 3,   VEGFR1↓, 4,   Vim?, 1,   Vim↓, 54,   Vim↑, 3,   vinculin↓, 1,   Zeb1↓, 16,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 4,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 2,   α-tubulin↑, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 86,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 140,   angioG↑, 4,   ATF4↓, 1,   ATF4↑, 11,   ATF4↝, 1,   EGFR↓, 64,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 8,   EGR1↑, 2,   Endoglin↑, 2,   eNOS↓, 4,   EPR↑, 4,   HIF-1↓, 12,   Hif1a↓, 98,   Hif1a↑, 3,   Hif1a↝, 1,   Hypoxia↓, 1,   LOX1↓, 1,   miR-126↑, 1,   miR-210↓, 1,   miR-34b-5p↑, 1,   NO↓, 5,   NO↑, 4,   NO↝, 1,   PDGFR-BB↓, 1,   TAMS↓, 1,   VEGF↓, 155,   VEGF↑, 3,   VEGF↝, 1,   VEGFR2/KDR/Flk1↓, 28,   p‑VEGFR2/KDR/Flk1↓, 1,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↓, 1,   BBB↑, 8,   BBB∅, 2,   CellMemb↑, 1,   CTR1↑, 1,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↓, 2,   NHE1↓, 1,   P-gp/ABCB1↓, 27,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   ASC↑, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 2,   CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 3,   COX1↓, 5,   COX2/PTGS2↓, 108,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CRP↓, 3,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 3,   IFN-γ↑, 2,   Igs↑, 1,   IKKα↓, 7,   IKKα↑, 2,   p‑IKKα↓, 3,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 3,   IL12↓, 3,   IL12↑, 2,   IL17↓, 2,   IL1α↓, 1,   IL1β↓, 17,   IL2↓, 3,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 2,   IL6↓, 51,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   IL8↑, 1,   Imm↑, 13,   Imm↝, 4,   Inflam↓, 42,   Inflam↑, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 3,   JAK↓, 11,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 16,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB?, 1,   NF-kB↓, 246,   NF-kB↑, 7,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 8,   p50↓, 3,   p65↓, 7,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 12,   PGE2↓, 25,   PSA↓, 10,   PSA↝, 1,   SOCS-3↓, 1,   SOCS-3↑, 2,   SOCS1↑, 1,   T-Cell↑, 3,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 7,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   IM↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↑, 1,   ADAM10↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 3,   NLRP3↑, 4,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 24,   AR↝, 1,   CDK6↓, 26,   CDK6↑, 4,   COMT↓, 2,   CYP19?, 1,   CYP19↓, 2,   ER(estro)↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 43,   BioAv↑, 56,   BioAv↝, 12,   BioEnh?, 1,   BioEnh↑, 7,   ChemoSen↓, 2,   ChemoSen↑, 191,   ChemoSen⇅, 2,   ChemoSen↝, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 3,   Dose↓, 3,   Dose↑, 7,   Dose↝, 69,   Dose∅, 8,   DrugR↓, 1,   eff?, 1,   eff↓, 58,   eff↑, 231,   eff↝, 11,   eff∅, 2,   Half-Life↓, 11,   Half-Life↝, 12,   Half-Life∅, 2,   MDR1↓, 12,   MRP1/ABCC1↓, 5,   P450↓, 5,   RadioS↑, 64,   selectivity?, 1,   selectivity↑, 102,   selectivity∅, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALP↓, 5,   AR↓, 24,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   BG↓, 1,   BMPs↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CEA↓, 2,   CRP↓, 3,   E6↓, 5,   E7↓, 5,   EGFR↓, 64,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 8,   EstroRS/ERS↓, 1,   EZH2↓, 6,   FOXM1↓, 6,   GutMicro↑, 11,   GutMicro↝, 1,   HemoG↓, 1,   HER2/EBBR2↓, 22,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 14,   IL6↓, 51,   IL6↑, 1,   IL6↝, 1,   Ki-67↓, 44,   KRAS↓, 1,   LDH↓, 7,   LDH↑, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 12,   PSA↓, 10,   PSA↝, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 5,   TRIB3↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 70,   AntiCan⇅, 1,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiP↑, 2,   AntiTum↓, 2,   AntiTum↑, 28,   Appetite↑, 2,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↑, 1,   chemoP↓, 1,   chemoP↑, 36,   chemoPv↑, 28,   ChemoSideEff↓, 6,   ChemoSideEff∅, 1,   cognitive?, 1,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 5,   K17↓, 1,   neuroP↑, 9,   NP/CIPN↓, 1,   OS↑, 14,   OS⇅, 1,   Pain↓, 4,   Pin1↓, 2,   PRAS40↑, 1,   QoL↑, 9,   radioP↑, 10,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 15,   Risk↑, 1,   Sleep↑, 2,   Strength↑, 2,   Symptoms↓, 1,   toxicity↓, 23,   toxicity↑, 2,   toxicity↝, 10,   TumVol↓, 29,   TumVol∅, 1,   TumW↓, 17,   TumW∅, 1,   Weight↑, 2,   Weight∅, 3,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   CD8+↑, 4,   Sepsis↓, 2,  
Total Targets: 1350

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   ACE/ACE1↓, 1,   ACE2↓, 1,   anemia↓, 1,   AntiBio↑, 12,   Aβ42↓, 3,   Buty↑, 1,   colonLen↑, 1,   compII↑, 1,   cough?, 1,   CYP2D6↓, 1,   diuretic↑, 3,   END↑, 1,   FFA/NEFA↓, 1,   FPN↑, 1,   GLP-1R↑, 1,   H+/K+-ATPase↓, 1,   Ingr↝, 3,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   Learn?, 1,   Learn↑, 1,   miR-107↑, 1,   Mucositis↓, 1,   NeuroI↓, 3,   NOX1↓, 1,   NOX2↓, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,   RBC↑, 1,   SCFAs↑, 1,   SLIT2↑, 1,   SoreThr?, 1,   SpO2↑, 1,   Stress↓, 1,   Stroke↓, 7,   TPH1↓, 1,   TRPA1↑, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 8,   antiOx↑, 129,   ARE↑, 2,   Catalase↑, 57,   Copper↓, 1,   CYP2E1↓, 1,   Fenton↓, 3,   Ferroptosis↓, 3,   GCLC↑, 4,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 40,   GPx1↑, 3,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 65,   GSH/GSSG↑, 1,   GSR↑, 8,   GSS↑, 1,   GSSG↓, 1,   GSTA1↓, 1,   GSTA1↑, 4,   GSTs↓, 1,   GSTs↑, 16,   H2O2↓, 7,   H2O2∅, 1,   HDL↓, 1,   HNE↓, 2,   HO-1↑, 49,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 5,   Keap1↑, 2,   lipid-P↓, 41,   lipid-P↑, 1,   MDA↓, 44,   MDA↑, 1,   MFN2↑, 1,   MPO↓, 7,   NOX4↓, 3,   NQO1↑, 5,   NRF2↓, 2,   NRF2↑, 84,   PARK2↑, 2,   Prx↑, 1,   RNS↓, 4,   ROS?, 1,   ROS↓, 167,   ROS↑, 3,   ROS⇅, 1,   ROS∅, 3,   mt-ROS↓, 2,   SIRT3↑, 3,   SOD↓, 1,   SOD↑, 68,   SOD1↑, 4,   SOD2↑, 5,   TAC↑, 8,   TBARS↓, 4,   Trx↑, 1,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 2,   VDAC1↓, 1,   VitC↑, 1,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   IronCh↓, 1,   IronCh↑, 8,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 5,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↓, 2,   MMP↑, 14,   MMP∅, 1,   mtDam↓, 2,   PGC-1α↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   adiP↑, 2,   ALAT↓, 13,   AMP↓, 1,   AMPK↓, 3,   AMPK↑, 20,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 1,   BUN↓, 1,   cAMP↑, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   CREB↑, 6,   p‑CREB↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 3,   FGF21↑, 1,   glucose↓, 6,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 5,   GLUT2↑, 1,   H2S↑, 2,   LDH↓, 8,   LDHA↑, 1,   LDL↓, 8,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 4,   NADPH∅, 1,   p‑PDK1 / PDPK1↓, 1,   PIP3↑, 1,   PKM2↓, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 6,   p‑PPARγ↓, 1,   SIRT1↑, 9,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt?, 1,   Akt↓, 28,   Akt↑, 65,   Akt↝, 4,   p‑Akt↓, 10,   p‑Akt↑, 17,   e-Akt↑, 1,   Apoptosis↓, 24,   Apoptosis↑, 1,   ATF2↑, 1,   BAD↓, 2,   BAX↓, 18,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 14,   Bcl-xL↑, 2,   BMP2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 26,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 3,   Casp6↓, 1,   Casp9↓, 6,   Cyt‑c↓, 5,   Cyt‑c∅, 1,   Ferroptosis↓, 3,   GADD34↓, 1,   GranB/GZMB↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 25,   iNOS↑, 1,   JNK↓, 5,   JNK↑, 1,   JNK↝, 1,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK↓, 26,   MAPK↑, 8,   MAPK↝, 3,   p38↓, 7,   p38↑, 3,   p‑p38↓, 3,   TRPV1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 7,   AntiThr↑, 6,   cJun↓, 1,   p‑cJun↓, 1,   other↓, 3,   other↑, 6,   other↝, 12,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   p‑eIF2α↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   HSP90↑, 2,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 2,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 2,   p16↓, 2,   P53↓, 4,   PCNA↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↓, 3,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↑, 1,   Diff↑, 1,   Diff↝, 1,   EMT↓, 1,   ERK↓, 5,   ERK↑, 15,   ERK↝, 1,   p‑ERK↑, 5,   e-ERK↑, 1,   FGF↑, 2,   FOXO1↝, 1,   FOXO3↑, 2,   GSK‐3β↓, 10,   GSK‐3β↑, 5,   p‑GSK‐3β↑, 3,   HDAC↓, 1,   HH↓, 1,   IGF-1↑, 1,   Jun↓, 1,   Mst1↓, 1,   mTOR↓, 11,   mTOR↑, 9,   mTOR↝, 1,   p‑mTOR↓, 3,   p‑mTOR↑, 3,   neuroG↑, 1,   p300↓, 1,   P70S6K↓, 1,   p‑P70S6K↑, 1,   PDGFRB↓, 1,   PI3K↓, 21,   PI3K↑, 46,   PI3K↝, 2,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PTEN↓, 7,   PTEN↑, 2,   p‑PTEN↓, 1,   RAS↓, 1,   RUNX2↑, 1,   STAT↓, 2,   STAT3↓, 3,   STAT3↑, 1,   STAT3↝, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 4,   5LO↝, 1,   AntiAg↓, 1,   AntiAg↑, 12,   AP-1↓, 2,   APP↓, 7,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 6,   Ca+2↑, 2,   Ca+2↝, 1,   Cartilage↑, 2,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP2↓, 1,   MMP3↓, 2,   MMP9↓, 8,   MMPs↑, 1,   MUC1↑, 1,   N-cadherin↑, 1,   Na+↑, 1,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   PKA↑, 3,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 4,   PTP1B↓, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   RAGE↓, 3,   Rho↓, 1,   Smad1↝, 1,   SMAD3↓, 1,   TGF-β↓, 5,   TGF-β↑, 3,   TGF-β↝, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TJ↑, 1,   Treg lymp↝, 1,   TRPC1↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 3,   uPA↓, 1,   VCAM-1↓, 4,   Vim↓, 1,   ZO-1↑, 1,   α-SMA↓, 3,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   ATF4↓, 3,   EGFR↓, 1,   Endoglin↑, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 16,   NO↑, 2,   PDGFR-BB↓, 1,   VEGF↓, 6,   VEGF↑, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 23,   BBB↝, 1,   GastroP↑, 2,   GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   IBI↑, 4,   MRP↓, 1,   Na+↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↑, 3,   COX1↓, 4,   COX2/PTGS2↓, 44,   CRP↓, 5,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 9,   IL10↑, 8,   IL12↓, 1,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 37,   IL2↓, 2,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 1,   IL5↓, 3,   IL6?, 1,   IL6↓, 49,   IL6↑, 2,   IL8↓, 6,   Imm↓, 1,   Imm↑, 9,   Inflam?, 1,   Inflam↓, 154,   Inflam↑, 3,   IκB?, 1,   IκB↓, 2,   JAK2↓, 1,   JAK2↑, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 77,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p65↓, 1,   PGE1↓, 1,   PGE2↓, 19,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR3↓, 1,   TLR4↓, 10,   TNF-α↓, 60,   TNF-α↑, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,   NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   AChE↓, 27,   AChE↑, 1,   ADAM10↑, 3,   BChE↓, 3,   BDNF↓, 1,   BDNF↑, 22,   BDNF⇅, 1,   ChAT↑, 2,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 6,   NGF↑, 4,   PSD95↑, 1,   tau↓, 10,   p‑tau↓, 13,   TrkB↓, 1,   TrkB↑, 7,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 34,   BACE/β-secretase↓, 13,   BACE/β-secretase↑, 1,   IDE↑, 1,   MAOB↓, 1,   NLRP3↓, 11,   NLRP3↑, 1,   PP2A↑, 3,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   GR↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 50,   BioAv↑, 49,   BioAv⇅, 1,   BioAv↝, 36,   BioEnh↑, 2,   ChemoSen↑, 2,   DDS↑, 1,   Dose↓, 2,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 19,   eff↓, 2,   eff↑, 28,   eff↝, 1,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 10,   Half-Life∅, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 3,   AST↓, 16,   BloodF↑, 2,   BMD↑, 5,   BP↓, 4,   BP↝, 1,   creat↓, 4,   CRP↓, 5,   EGFR↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   GutMicro↑, 16,   HemoG↑, 1,   IL6?, 1,   IL6↓, 49,   IL6↑, 2,   LDH↓, 8,   RAGE↓, 3,   TP53↑, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll↑, 5,   AntiArt↑, 8,   AntiCan↑, 17,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 27,   AntiMyl↑, 1,   AntiP↑, 8,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 4,   Bone Healing↑, 1,   cardioP↓, 1,   cardioP↑, 52,   chemoP↑, 8,   chemoPv↑, 9,   cognitive↓, 1,   cognitive↑, 45,   fatigue↓, 1,   GFR↑, 1,   hepatoP↑, 46,   memory?, 1,   memory↑, 49,   motorD↑, 6,   neuroP?, 1,   neuroP↑, 117,   Obesity↓, 10,   OS↑, 2,   Pain↓, 5,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 19,   Risk↓, 2,   Strength↑, 1,   toxicity↓, 37,   toxicity↑, 3,   toxicity↝, 10,   toxicity∅, 10,   Weight↑, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 8,   AntiViral↑, 11,   Bacteria↓, 16,   Bacteria↑, 1,   CD8+↑, 1,   Diar↓, 1,   IRF3↓, 1,   Sepsis↓, 7,  
Total Targets: 587

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
30 Quercetin
26 Apigenin (mainly Parsley)
25 Thymoquinone
22 Baicalein
22 Fisetin
20 Luteolin
20 Resveratrol
19 Kaempferol
16 Berberine
16 Chrysin
14 Lycopene
14 Shikonin
13 Alpha-Lipoic-Acid
12 Magnetic Fields
12 Emodin
12 Sulforaphane (mainly Broccoli)
11 Formononetin
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
10 Licochalcone A
10 Magnolol
9 5-fluorouracil
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 HydroxyTyrosol
9 Isobavachalcone
9 Inositol
9 Ivermectin
9 Licorice
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Garcinol
8 Hyperoside
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 isoorientin
8 Piperlongumine
8 Urolithin
7 Isovitexin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 Radiotherapy/Radiation
7 Gambogic Acid
7 Indole-3-carbinol
7 Isoliquiritigenin
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 Celastrol
6 Dandelion Root
6 Ferulic acid
6 Fucoidan
6 Gallic acid
6 Vitexin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Ginkgolide B
5 Ginseng
5 itraconazole
5 Lactoferrin/Talactoferrin
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Paclitaxel/Taxol
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Caffeic acid
4 Celecoxib
4 Ginkgetin
4 Hydrogen Gas
4 Hibiscus sabdariffa
4 Juglone
4 Lasiodin
4 Lutein
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 3-bromopyruvate
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Thymol-Thymus vulgaris
3 chaetocin
3 Hydroxycinnamic-acid
3 Cucurbitacin
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Evodiamine
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 isoquercitrin
3 lambertianic acid
3 SDG/lignans
3 Linalool
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geldanamycin
2 Genistein (soy isoflavone)
2 Geraniol
2 Huperzine A/Huperzia serrata
2 Inulin Prebiotic
2 Melatonin
2 Magnesium
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 chemodynamic therapy
1 Camptothecin
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 Photodynamic Therapy
1 gefitinib, erlotinib
1 Cynaropicrin
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Bortezomib
1 chitosan
1 Ginkgolic acids
1 Ginkgo biloba
1 Gossypol/AT-101
1 Graviola
1 hydrogen sulfide
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 isoflavones
1 Laetrile B17 Amygdalin
1 low dose naltrexone
1 Lemongrass Extract/Citral
1 Mung Bean Sprouts
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Phenolic Acids
1 Psoralidin
1 Rhein
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 acetazolamide
1 statins
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page