GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, Synergy↑,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
1406- AgNPs,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Nor, NA
*ROS↓, *GPx↑, *Catalase↑, *ROS↑,
1905- AgNPs,    Evaluation of the effect of silver and silver nanoparticles on the function of selenoproteins using an in-vitro model of the fish intestine: The cell line RTgutGC
- in-vivo, Nor, NA
*TrxR↓, *ROS∅, GPx↑,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
335- AgNPs,  PDT,    Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy
- Review, Var, NA
ROS↑, GSH↓, GPx↑, Catalase↓, SOD↓, p38↑, BAX↑, Bcl-2↓,
324- AgNPs,  CPT,    Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
- in-vitro, Cerv, HeLa
ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, Nor, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3448- ALA,    Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line
- in-vitro, Nor, NA
*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1562- Api,    Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- in-vitro, Vit, NA
*SOD↑, *Catalase↑, *GPx↑, *MDA↓, *NRF2↑, *toxicity∅,
3884- Api,    Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
3159- Ash,    Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model
- in-vitro, Park, SH-SY5Y
*neuroP↑, *Inflam↓, *ROS↓, *cognitive↑, *memory↑, *GPx↑, *Prx↓, *ATP↑, *Vim↓, *mtDam↓,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP/DDIT3↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
4806- ASTX,    Astaxanthin's Impact on Colorectal Cancer: Examining Apoptosis, Antioxidant Enzymes, and Gene Expression
- in-vitro, CRC, HCT116
BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, MDA↓, ROS↓, SOD↑, Catalase↑, GPx↑, antiOx↑, TumCG↓, TumCP↓,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
7949- BuckWS,    Producing High-Quality Buckwheat Sprouts: The Combined Effects of Melatonin and UV-B Treatment
- Study, Nor, NA
*eff↑, *SOD↑, *GPx↑, *Catalase↑, *other↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5902- CAR,    A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol
- in-vitro, Nor, HEK293
*other↓, *GSH↑, *GPx↑, *ROS↓, *Apoptosis↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,

Showing Research Papers: 1 to 50 of 252
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 9,   Catalase↓, 12,   Catalase↑, 13,   GPx↓, 20,   GPx↑, 28,   GPx4↓, 3,   GSH↓, 20,   GSH↑, 9,   GSH⇅, 1,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 2,   HO-1↑, 8,   Iron↑, 4,   Iron↝, 1,   lipid-P↓, 5,   lipid-P↑, 11,   MDA?, 1,   MDA↓, 5,   MDA↑, 6,   MPO↓, 2,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 12,   ROS↓, 15,   ROS↑, 71,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↑, 1,   SOD↓, 12,   SOD↑, 15,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↓, 1,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↑, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compIV↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 10,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 3,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 2,   ATP↓, 6,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 6,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 3,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 3,   Pyruv↓, 2,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 49,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 2,   Bcl-2↓, 29,   Bcl-2↑, 5,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 7,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 39,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 12,   Casp9↑, 27,   cl‑Casp9↑, 1,   Cyt‑c↑, 18,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 6,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 5,   Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 8,   TumCD↑, 5,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 33,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 6,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 5,   MAPK↑, 6,   MAPK↝, 1,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   mTOR↝, 1,   p‑mTOR↓, 3,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 25,   PI3K↑, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 2,   RAS↓, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 3,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 1,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 3,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 1,   tumCV↓, 14,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 9,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 6,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↑, 1,   P53↓, 3,   P53↑, 28,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 9,   cl‑PARP∅, 1,   PCNA↓, 13,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↑, 5,   pRB↓, 1,   pRB↑, 1,   RB1↑, 1,   TumCCA↑, 45,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 3,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 10,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 34,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 2,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 8,   EMT↓, 12,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 22,   MMP9↑, 2,   MMPs↓, 5,   N-cadherin↓, 9,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 18,   TumMeta↓, 17,   TumMeta↑, 3,   Twist↓, 2,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 18,   NO↓, 2,   NO↑, 2,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 18,   MMP↑, 2,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 2,   IL6↓, 15,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 8,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 5,   PSA↓, 2,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 14,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ER-α36↓, 1,   Estro↝, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 6,   BioAv↝, 4,   BioEnh?, 1,   ChemoSen↑, 43,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 5,   Dose↝, 15,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 1,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 13,   selectivity↑, 23,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 6,   AST↓, 2,   BP↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 6,   EGFR↑, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 15,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 2,   PSA∅, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 20,   antiNeop↑, 1,   AntiTum↑, 6,   Appetite↑, 1,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 7,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 8,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 10,   RenoP↑, 2,   Risk↓, 9,   Sleep↑, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 565

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 4,   antiOx↑, 102,   ARE↑, 2,   Bil↓, 2,   Catalase↓, 4,   Catalase↑, 123,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 6,   GPx↑, 202,   GPx↝, 1,   GPx∅, 1,   GPx4↓, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 89,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 25,   GSSG↓, 3,   GSTs↓, 2,   GSTs↑, 24,   H2O2↓, 9,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 5,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 8,   Keap1↝, 1,   lipid-P↓, 62,   MDA↓, 84,   MDA↑, 3,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 11,   NRF2↓, 1,   NRF2↑, 82,   Prx↓, 1,   Prx↑, 2,   RNS↓, 1,   ROS?, 2,   ROS↓, 164,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 5,   SOD?, 1,   SOD↓, 2,   SOD↑, 160,   SOD↝, 1,   SOD1↑, 4,   SOD2↑, 6,   TAC↑, 15,   TBARS↓, 3,   TBARS↑, 1,   Thiols↑, 2,   Trx↑, 3,   Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 7,   VitE↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTL↓, 1,   IronCh↑, 4,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   EGF↓, 1,   ETC↑, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN1↑, 1,   MFN2↑, 2,   mtDam↓, 2,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   mt-ACC⇅, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 25,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 11,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↑, 1,   glucose↓, 7,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 10,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 13,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDKs↑, 1,   PFK↓, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PONs↑, 1,   PPP↓, 1,   SCFAs↑, 2,   SIRT1↑, 14,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 18,   BAD↓, 1,   BAX↓, 15,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 11,   Bcl-2↝, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 26,   cl‑Casp3↓, 2,   proCasp3↑, 1,   Casp8↓, 1,   Casp9↓, 11,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 4,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 4,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 2,   IκB?, 1,   JAK2↓, 1,   JNK↓, 7,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 3,   PI3K↑, 4,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ?, 1,   PP2A↑, 1,   PTEN↓, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 2,   HDAC?, 1,   HDAC↓, 1,   miR-34a↓, 1,   other?, 1,   other↓, 7,   other↑, 12,   other↝, 3,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   P53↓, 1,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CHIP↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↑, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   AP-1↑, 1,   ATPase↑, 1,   Ca+2↓, 8,   Ca+2↝, 2,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MUC1↑, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 2,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Vim↓, 3,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 22,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   GastroP↑, 4,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 1,   MMP↑, 10,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPM7⇅, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 42,   COX2/PTGS2↑, 2,   Eos↓, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↓, 5,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 1,   IL10↓, 7,   IL10↑, 12,   IL12↓, 2,   IL12↑, 1,   IL13↓, 1,   IL17↓, 5,   IL18↓, 1,   IL1β↓, 43,   IL2↓, 3,   IL2↑, 2,   IL23↓, 2,   IL4↓, 4,   IL4↑, 3,   IL5↓, 2,   IL6↓, 44,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↓, 1,   Imm↑, 6,   INF-γ↓, 2,   Inflam↓, 106,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   NF-kB↓, 49,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 8,   p65↓, 1,   PGE2↓, 14,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 13,   TNF-α↓, 60,   TNF-α↑, 2,   TRAF6↓, 1,   TRIF↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 6,   Ach↑, 9,   AChE↓, 31,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 18,   BDNF⇅, 1,   ChAT↑, 8,   GABA↑, 3,   MAOA↓, 3,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 2,   BACE/β-secretase↓, 9,   tau↓, 8,   p‑tau↓, 8,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 5,   GR↝, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 40,   BioAv⇅, 1,   BioAv↝, 23,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 23,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 7,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 25,   ALAT↑, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 27,   AST↑, 1,   BG↓, 3,   Bil↓, 2,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BP↝, 1,   BUN↓, 3,   Calcium↑, 1,   CEA↓, 2,   creat↓, 5,   CRP↓, 8,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 44,   IL6↑, 1,   IRes↝, 1,   LDH↓, 10,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 5,   Urea↓, 3,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 12,   AntiArt↑, 4,   AntiCan↑, 12,   AntiDiabetic↑, 18,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↑, 1,   BOLD↑, 1,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 36,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 44,   Learn↑, 2,   memory↑, 37,   motorD↑, 6,   neuroP↑, 82,   NP/CIPN↓, 1,   Obesity↓, 12,   OS↑, 2,   Pain↓, 4,   radioP↑, 3,   RenoP↑, 14,   Risk↓, 7,   Sleep↑, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity↓, 14,   toxicity↝, 8,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 10,   GutMicro↑, 24,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 2,  
Total Targets: 535

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Lycopene
9 Thymoquinone
8 Melatonin
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Hydrogen Gas
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Sulforaphane (mainly Broccoli)
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hyperoside
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Luteolin
3 Moringa oleifera
3 Morin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Berberine
2 Phenethyl isothiocyanate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Sesame seeds and Oil
2 doxorubicin
2 isoorientin
2 Kaempferol
2 Matrine
2 Cisplatin
2 Methylsulfonylmethane
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Cichoric acid / Chicoric acid
1 Citicoline, CDP-Choline
1 Citric Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 Butein
1 Scopoletin
1 Isothiocyanates
1 Juglone
1 Lactoferrin/Talactoferrin
1 Vitamin E
1 Magnolol
1 Mung Bean Sprouts
1 methylseleninic acid
1 Magnetic Field Rotating
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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