MRP1/ABCC1 Cancer Research Results

MRP1/ABCC1, Multidrug Resistance Protein 1: Click to Expand ⟱
Source:
Type:
Multidrug resistance protein 1 (MRP1) encoded by ABCC1 gene.
MRP1 levels are elevated in numerous cancer types, NSCLC, breast cancer, and prostate cancer Multidrug Resistance Protein 1 (MDR1), also known as P-glycoprotein (P-gp) or ABCB1, is a membrane protein that functions as an efflux pump, transporting a variety of drugs and xenobiotics out of cells. Its expression is a significant factor in the development of multidrug resistance (MDR) in cancer therapy.

Resistance Protein 1 (MDR1) is often upregulated in various cancers, and its high expression is associated with poor prognosis and protumorigenic effects due to its role in drug resistance.
Field Suggested Entry
Target ABCC1 / MRP1
Full Name ATP-binding cassette subfamily C member 1 / multidrug resistance-associated protein 1
Target Class ATP-dependent ABC efflux transporter
Primary Biology Efflux of drugs, xenobiotics, organic anions, glutathione conjugates, oxidized glutathione, and inflammatory lipid mediators
Cancer Relevance High: contributes to multidrug resistance by exporting anticancer drugs and reducing intracellular drug accumulation
AD Relevance Medium: possible role in amyloid-β clearance and barrier transporter function, but less established than ABCB1/P-gp and LRP1
Therapeutic Direction Context-dependent. In cancer, inhibition/down-modulation may improve chemotherapy retention in tumor cells. In AD, support/upregulation may be desirable if enhancing amyloid-β clearance. Systemic inhibition may increase normal-tissue toxicity.


Scientific Papers found: Click to Expand⟱
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1/ABCC1↓, *5HT↑, *GABA↑, *eff↑,
5695- BRU,    Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- in-vitro, Lung, A549
NRF2↓, ChemoSen↑, Apoptosis↑, TumCP↓, TumCG↓, MRP1/ABCC1↓, GSH↓, cMyc↓,
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2↓, ChemoSen↑, MDR1↓, MRP1/ABCC1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp↓, PI3K↓, Akt↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, eff↑, chemoPv↑, BioAv↑,
5328- TFdiG,    Study on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer
- in-vitro, NA, Caco-2
BioAv↓, P-gp↑, MRP1/ABCC1↑, ROS↑, *BioAv↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

AntiBio↓, 1,   CB2 / CNR2↑, 1,  

Redox & Oxidative Stress ⓘ

GSH↓, 2,   HO-1↓, 1,   HO-1↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 1,   Prx4↑, 1,   ROS↑, 6,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 2,   Glycolysis↓, 1,   HK2↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 5,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 2,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MAPK↓, 1,   necrosis↑, 1,   p27↑, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

PhotoS↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   XBP-1↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   DNArepair↓, 1,   P53↓, 1,   PARP↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑ERK↓, 2,   GSK‐3β↓, 1,   mTOR↓, 2,   PI3K↓, 2,   PTEN↑, 1,   RAS↓, 1,   STAT1↓, 1,   STAT3↓, 2,   STAT6↓, 1,   TumCG↓, 3,  

Migration ⓘ

AP-1↓, 1,   E-cadherin↓, 1,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 2,   ROCK1↓, 1,   SOX4↑, 1,   TumCI↓, 2,   TumCP↓, 1,   TumCP↑, 1,   TumMeta↓, 2,   Twist↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↝, 1,   EPR↑, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 3,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 3,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   COMT↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 6,   Dose↝, 1,   eff↑, 3,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 7,   MRP1/ABCC1↑, 1,   RadioS↑, 3,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   Pain↓, 1,   toxicity↝, 2,  
Total Targets: 112

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   P-gp↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   GABA↑, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   BioAv↑, 1,   BioAv⇅, 1,   BioEnh↑, 1,   Dose↑, 1,   eff↑, 1,   MRP1/ABCC1↓, 1,  

Functional Outcomes ⓘ

toxicity⇅, 1,  
Total Targets: 17

Scientific Paper Hit Count for: MRP1/ABCC1, Multidrug Resistance Protein 1
2 brusatol
1 Baicalein
1 Baicalin
1 doxorubicin
1 Beta-Caryophyllene
1 Brucea javanica
1 borneol
1 Celecoxib
1 Cisplatin
1 Piperlongumine
1 Quercetin
1 EGCG (Epigallocatechin Gallate)
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:424  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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