Casp7 Cancer Research Results

Casp7, Caspase-7: Click to Expand ⟱
Source:
Type:
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, −8, −9 and −10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, −6, and −7) that carry out the demolition phase of apoptosis. Downregulation of caspase-3 is an effective apoptosis-evading mechanism frequently observed in cancer cells in association with acquired chemoresistance to apoptosis-inducing anticancer drugs. Indeed, re-expression of caspase-3 often restores sensitivity to apoptosis.
Caspase-7:
Role: Executioner caspase similar to caspase-3.
Cancers: Expression levels can vary; often studied in breast and prostate cancers.
Prognosis: Its prognostic value is less clear and may depend on the cancer type.
Scientific Papers found: Click to Expand⟱
5459- AF,    Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
- in-vitro, Ovarian, NA
ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, Synergy↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, Synergy↑,
5145- AgNPs,    Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP/DDIT3↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,
351- AgNPs,    Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
Casp9↑, Casp3↑, Casp7↑, Bcl-2↓,
377- AgNPs,    Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis
- in-vitro, BC, SkBr3
ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,
381- AgNPs,    Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression
- in-vitro, Bladder, 5637
ROS↑, BAX↑, Bcl-2↓, Casp3↑, Casp7↑, Apoptosis↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
2755- BetA,    Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines
- in-vitro, Colon, HT29 - in-vitro, BC, MCF7 - in-vitro, Lung, H460
eff↑, Casp3↑, Casp7↑, NF-kB↓,
2744- BetA,    Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
- Review, Var, NA
Apoptosis↓, TumCCA↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, MMP↓, ROS↑, TOP1↓, NF-kB↓,
9203- BITC,    Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,
9164- BITC,    Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3
TumCG↓, MMP↓, Casp3↑, Casp7↑, DNAdam↑, ROS↑, eff↓,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1/ATG6↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,
9263- BTB,    Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Casp3↑, Casp7↑, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, MMP↓, DNAdam↑, Imm↑, angioG↑,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5919- Cats,  Cisplatin,    Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity
- in-vitro, Liver, HepG2
ROS↑, GSH↓, Apoptosis↑, Casp3↑, Casp7↑, NF-kB↓, selectivity↑, ChemoSen↑, chemoP↑,
6124- CHr,  EGCG,    The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
- in-vitro, HCC, HepG2
TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, Synergy↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,
2805- CHr,    Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
- in-vitro, ESCC, KYSE150 - in-vivo, ESCC, NA
FAK↓, GlucoseCon↓, Casp3↑, Casp7↑, p‑Akt↓, TumCG↓, Weight∅,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
6165- Cin,  doxoR,    Cinnamaldehyde potentiates cytotoxic and apoptogenic effects of doxorubicin in prostate cancer cell line
- in-vitro, Pca, PC3
ChemoSen↑, ROS↑, Casp3↑, Casp7↑,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
9101- CV,    Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model
- vitro+vivo, BC, MCF7
Dose↝, AntiTum↑, Casp7↑, VEGF↓, tumCV↓, TumCCA↑, MMP↓, ROS↑,
6686- DAP,    Lactoferrin-encapsulated dichloroacetophenone (DAP) nanoparticles enhance drug delivery and anti-tumor efficacy in prostate cancer
- in-vivo, Pca, NA
PDK1 / PDPK1↓, TumCP↓, TumCMig↓, BioAv↓, CompStab↑, Apoptosis↑, Casp3↑, Casp7↑, Glycolysis↓, CompStab↓,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6584- EU,    Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
- Review, Var, NA
*AntiAge↑, *Inflam↓, *antiOx↑, TumCD↑, Bcl-2↓, cl‑Casp7↑, cl‑PARP↑, BAX↑, P53↑, tumCV↓, selectivity↑, *testos↑, *PSA∅,
6332- Eug,    Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCP↓, MMP2↓, MMP9↓, TIMP1↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑,
6858- FBZ,    Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells
- in-vitro, Lung, A549
Synergy↑, mt-ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, PARP↑, TumCCA↑, cycA1/CCNA1↓, cycE/CCNE↓,
2859- FIS,    The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- in-vitro, Liver, HepG2 - NA, Colon, Caco-2
TumCG↓, other↝, Casp3↑, Casp7↑, PGE2↓, GSTs↓, Wnt↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, P53↑, P21↑, P450↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
7009- Fuc,    Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
selectivity↑, TumCCA↑, Casp3↑, Casp7↑, Casp9↑, ChemoSen↑, chemoP↑,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
7136- GI,    [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2
- vitro+vivo, NSCLC, H1650
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, EGFR↓, STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, TumCG↓, Ki-67↓, eff↑, Dose↝,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,

Showing Research Papers: 1 to 50 of 116
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 116

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 2,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 12,   GSH↑, 2,   GSH/GSSG↓, 2,   GSR↓, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   mt-H2O2↑, 1,   HO-1↑, 4,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 4,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 4,   OSI↑, 1,   Prx4↑, 1,   ROS↓, 4,   ROS↑, 44,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 4,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 4,   OCR↓, 2,   mt-OXPHOS↓, 1,   PHB↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACSL4↑, 1,   ALAT↝, 1,   AMP↑, 1,   AMPK↑, 3,   ATP↓, 4,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 5,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 3,   LDL↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 2,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 58,   BAD↓, 2,   BAD↑, 4,   p‑BAD↓, 1,   Bak↑, 3,   BAX↑, 36,   Bax:Bcl2↑, 7,   Bcl-2↓, 40,   Bcl-2↑, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 6,   BID↑, 4,   p‑BID↓, 1,   BIM↑, 2,   BOK↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 87,   cl‑Casp3↑, 13,   Casp6↑, 1,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 98,   cl‑Casp7↑, 15,   Casp8↑, 13,   cl‑Casp8↑, 4,   Casp9?, 1,   Casp9↑, 42,   cl‑Casp9↑, 7,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   Diablo↑, 1,   DR5↑, 3,   FADD↑, 2,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 2,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 2,   Mcl-1↓, 5,   p‑Mcl-1↓, 1,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   NAIP↓, 1,   p38↓, 1,   p38↑, 8,   p‑p38↑, 1,   PUMA↑, 2,   RIP3↑, 1,   survivin↓, 21,   TRAIL↑, 2,   TumCD↓, 1,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 20,   p‑Akt↓, 8,   AKT1↓, 2,   CK2↓, 2,   cMET↓, 1,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 9,   ERK↓, 12,   ERK↑, 2,   e-ERK↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 3,   p‑MAPK↓, 1,   MKK4↓, 1,   mTOR↓, 12,   p‑mTOR↓, 2,   PDGFRA↓, 1,   PI3K↓, 18,   PTEN↑, 5,   p‑PTEN↓, 1,   RAS↓, 2,   RIP1↑, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   c-Src↓, 1,   STAT3↓, 11,   p‑STAT3↓, 4,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF4↑, 4,   ATF4↝, 1,   cJun↓, 1,   cMyc↓, 13,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   p‑FOXO3↓, 1,   H3↓, 1,   HATs↓, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   miR-21↓, 1,   miR-339-5p↝, 1,   Myc↓, 2,   OCT4↓, 4,   other↑, 1,   other↝, 1,   SOX2↓, 1,   SOX4↑, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 9,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↑, 24,   P53↓, 1,   P53↑, 26,   P53∅, 1,   PARP↑, 8,   PARP↝, 1,   cl‑PARP↑, 33,   PARP1↑, 1,   PCNA↓, 8,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 6,   p‑CDK2↓, 2,   CDK4↓, 11,   p‑CDK4↓, 1,   CDK6↓, 4,   CDKN2C/p18↑, 1,   p‑CHK1↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 22,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   cycE1↓, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 3,   P21↑, 14,   p27/CDKN1B↑, 4,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 41,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   cFos↓, 1,   CSCs↓, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 4,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 3,   STAT1↓, 1,   TumCG↓, 20,   TumCP↓, 32,   TumCP↑, 2,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 6,   cal2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 7,   EM↑, 1,   EMT↓, 15,   FAK↓, 3,   GLI2↓, 2,   hnRNPA1↓, 1,   ITGB4↓, 1,   LEF1↓, 2,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 14,   MMPs↓, 5,   N-cadherin↓, 6,   PAI-1/SERPINE1↑, 1,   PCBP1↓, 1,   Slug↓, 5,   Snail↓, 9,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TumCI↓, 16,   TumCMig↓, 10,   TumMeta↓, 17,   Twist↓, 6,   TXNIP↑, 2,   uPA↓, 3,   Vim↓, 6,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 15,   angioG↑, 2,   CD31/PECAM-1↓, 2,   HIF-1↓, 1,   Hif1a↓, 11,   VCAM-1↓, 1,   VEGF↓, 21,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   EPR↑, 1,   GLUT1↓, 2,   IBI↑, 1,   MMP?, 1,   MMP↓, 21,   MMP∅, 1,   MPT↑, 2,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 12,   CXCR4↓, 3,   DR4↑, 1,   ICAM-1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 5,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 5,   MCT1↓, 1,   NF-kB↓, 19,   p‑NF-kB↑, 1,   NK cell↑, 2,   p50↓, 1,   PGE2↓, 3,   PSA↓, 2,   SOCS-3↓, 1,   TCF↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↑, 24,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose↑, 2,   Dose↝, 12,   Dose∅, 2,   eff↓, 12,   eff↑, 13,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 6,   selectivity?, 1,   selectivity↑, 24,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↝, 1,   ALP↝, 1,   AR↓, 3,   AST↝, 1,   p‑BRCA1↑, 1,   EGFR↓, 9,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 5,   LDH↓, 1,   LDH↑, 1,   Myc↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 1,   chemoP↑, 6,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 1,   PFS↑, 1,   RenoP↑, 1,   Risk↓, 5,   toxicity↓, 2,   toxicity↝, 1,   TumNum↓, 1,   TumVol↓, 7,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 438

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 8,   GPx↑, 8,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 7,   MDA↓, 3,   NRF2↑, 2,   ROS↓, 13,   SOD↑, 8,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   HMG-CoA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp7↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   MAPK↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GastroP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 5,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 3,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 19,   NF-kB↓, 3,   NK cell↑, 2,   PGE2↓, 2,   PSA∅, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 3,   Dose↝, 2,   GSTA1↑, 1,   Half-Life↝, 2,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 3,   LDH↓, 1,   PSA∅, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 6,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 6,   chemoPv↑, 1,   diuretic↑, 1,   hepatoP↑, 6,   neuroP↑, 11,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↓, 1,   AntiViral↑, 4,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 104

Scientific Paper Hit Count for: Casp7, Caspase-7
8 Thymoquinone
6 EGCG (Epigallocatechin Gallate)
6 Kaempferol
5 Quercetin
5 Sulforaphane (mainly Broccoli)
5 Magnetic Fields
4 Silver-NanoParticles
3 Cisplatin
3 Chrysin
3 Fucoidan
3 Marjoram (Origanum majorana)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 Cinnamon
2 doxorubicin
2 Echinacea
2 Fisetin
2 Graviola
2 Lemon Balm/Melissa officinalis
2 Phenylbutyrate
2 Piperlongumine
1 Auranofin
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Bromelain
1 borneol
1 Black turtle bean
1 Caffeic acid
1 Carvacrol
1 Cat’s Claw
1 Cucurbitacin
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 Docetaxel
1 Emodin
1 Eurycomanone
1 Eugenol
1 Fenbendazole
1 Flaxseed/Linseed
1 Ginger/6-Shogaol/Gingerol
1 Hibiscus sabdariffa
1 Honokiol
1 Inulin Prebiotic
1 Isoliquiritigenin
1 Ivermectin
1 Juglone
1 Lapachol
1 Licochalcone A
1 Licorice
1 Luteolin
1 Lycopene
1 Magnolol
1 Matrine
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 Mangiferin
1 magnetic nanoparticles
1 Iron
1 Moringa oleifera
1 Methylsulfonylmethane
1 Nimbolide
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Shikonin
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:43  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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