IFN-γ Cancer Research Results

IFN-γ, Interferon-γ: Click to Expand ⟱
Source:
Type:
Plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer.
Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression.
However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application.

IFN-γ is often expressed in the tumor microenvironment, particularly in response to immune cell infiltration. Its expression can be influenced by the presence of tumor-infiltrating lymphocytes (TILs) and other immune cells.
High levels of IFN-γ are typically associated with a Th1 immune response, which is generally considered beneficial for anti-tumor immunity.

Tumor Suppression:
In many cases, IFN-γ has tumor-suppressive effects, as it can inhibit tumor cell proliferation and induce apoptosis in certain cancer types.
Scientific Papers found: Click to Expand⟱
9259- Acai, EO,    Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model
- vitro+vivo, Pca, LNCaP
Ingr↝, eff↝, Dose↝, TumVol↓, necrosis↑, IL6↓, IFN-γ↓,
9260- Acai, EO,    Anticancer potential, molecular mechanisms and toxicity of Euterpe oleracea extract (açaí): A systematic review
- Review, Var, NA
Dose↝, Risk↓, chemoPv↑, TumCP↓, Inflam↓, toxicity↓, IFN-γ↑, IL5↓, IL8↓, MPO↓, TNF-α↓, IL1β↓, IL6↓, PCNA↓, Ki-67↓, Casp3↑, Bcl-2↓, toxicity↓,
1000- AG,  5-FU,    Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation
- vitro+vivo, BC, 4T1
TumCG↓, TumCCA↑, Apoptosis↑, *IL2↑, *TNF-α↑, *IFN-γ↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, Var, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, Var, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
*GutMicro↑, *IL6↑, *IL10↑, *IL17↑, *IFN-γ↑, PDGF↓, *RAD51↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5622- Bif,    Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice
- in-vivo, Var, NA
eff↑, Imm↑, IFN-γ↑,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
741- Bor,    Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MOB1↓, PD-L1↑, p‑YAP/TEAD↝, IFN-γ↓, sFasL↑, Perforin↓, GranA↓, GranB/GZMB↓, GNLY↓, PD-1↑,
9265- BTB,    Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets
- in-vivo, Nor, NA
*other↝, *LDL↓, *TG/TAG↓, *IL4↝, *IL5↝, *IFN-γ↝, *TNF-α↝, *IRes↓, *GutMicro↑,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *LTA/TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
1205- Caff,  immuno,    Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody
- in-vivo, Melanoma, B16-F10
OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, IFN-γ↑, IL12↑, IL15↑, STAT4↑, NF-kB↑, DCells↑,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,
423- CUR,    Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TLR4↓, IRF3↓, IFN-γ↓, TRIF↓,
451- CUR,    The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
- vitro+vivo, HNSCC, SCC15 - vitro+vivo, HNSCC, SNU1076 - vitro+vivo, HNSCC, SNU1041
TumCMig↓, TumCG↓, PD-L1↓, PD-L2↓, Galectin-9↓, EMT↓, T-Cell↑, TILs↑, PD-1↓, TIM-3↓, CD4+↓, CD25+↓, FoxP3+↓, E-cadherin↑, CD8+↑, IFN-γ↑,
9097- CV,    Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial)
- Trial, Nor, NA
*Dose↝, *IFN-γ↑, *NK cell↑,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6749- DHA,    The effects of docosahexaenoic acid (DHA) on plasma cytokines, oxylipins, and tumor-infiltrating lymphocytes from women with breast cancer undergoing neoadjuvant chemotherapy in the DHA-WIN trial
- Trial, BC, NA
*IFN-γ↑, *TNF-α↑, Imm↑,
6750- DHA,  Chemo,    Docosahexaenoic acid (DHA) supplementation attenuates changes in the concentration, phenotype, and response of immune peripheral blood cells in breast cancer patients undergoing neoadjuvant therapy. Secondary findings from the DHA-WIN trial
- Trial, BC, NA
*CD14↑, *NLR↓, eff↑, *IL4↑, *IL10↑, *IFN-γ↑, *TNF-α↑, Imm↑, eff↑, TumW↓,
6715- dietF,    Are Fermented Foods Effective against Inflammatory Diseases?
- Review, Nor, NA
*Imm↑, *GastroP↑, *Inflam↓, AntiCan↑, *AntiBio↑, *hepatoP↑, *CD4+↑, *IFN-γ↓, *IL17↓, *GutMicro↑, *antiOx↑, *AST↓, *ALAT↓, *HDL↑, *LDL↓, *ROS↓, *lipid-P↓, *Inflam↓, *Aβ↓,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
5487- EP,    High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas
- in-vivo, GBM, NA
OS↑, CellMemb↑, Imm↑, Inflam↓, necrosis↑, Pyro↑, eff↑, IL2↑, IL6↑, IL17↑, IFN-γ↓,
6792- EPA,    Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico
- Trial, HNSCC, NA
Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, QoL↑,
8608- FSO,  Cisplatin,    Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
- in-vivo, Cerv, NA
TumVol↓, TumW↓, ChemoSen↑, *TAC↑, lipid-P↑, CD8+↑, IFN-γ↑, IL4↓, E6↓, E7↓, P53↑,
1283- GA,  immuno,    Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy
- vitro+vivo, CRC, NA
p‑STAT3↓, Treg lymp↓, FOXP3↓, CD8+↑, IFN-γ↑,
7117- Ge-132,    Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts
- in-vitro, Nor, NA
*IL6↓, *Apoptosis↓, *toxicity↓, Imm↑, IFN-γ↑, NK cell↑, AntiTum↑, Pain↓, *Wound Healing↑,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
4346- H2,    Medical Application of Hydrogen in Hematological Diseases
- Review, Var, NA
*AntiAg↑, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
1004- HNK,  RAPA,    Honokiol downregulates PD-L1 expression and enhances antitumor effects of mTOR inhibitors in renal cancer cells
- in-vitro, RCC, NA
Apoptosis↑, TumCCA↑, ROS↑, PD-L1↓, IFN-γ↓,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- in-vitro, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3529- Lyco,    The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *ROS↓, *TNF-α↓, *IFN-γ↓, IL10↓,
1041- Lyco,  immuno,    Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells
- in-vivo, Lung, NA
TumVol↓, TumW↓, eff↑, IL1↑, IFN-γ↑, IL4↓, IL10↓,
8640- MBZ,  GB,    Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231
Synergy↑, tumCV↓, EGFR↓, RCC1↓, MMP2↓, STAT4↓, IL6↓, IL1β↓, TNF-α↑, IFN-γ↓,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- in-vitro, MS, NA
*CD4+↑, *MCP1/CCL2↓, RANTES↓, *MIP‑1α/CCL3↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,
9081- MGF,    Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma
- in-vitro, Melanoma, NA
Inflam↓, lipid-P↓, NF-kB↓, IL6↓, TNF-α↓, IFN-γ↓, VEGF↓, uPA↓, MCP1/CCL2↓, PGF↓, angioG↓,
8956- mushLions,  5-FU,    Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota
- in-vivo, Var, NA
TumCG↓, Inflam↓, IFN-γ↓, IL1β↓, IL2↓, IL6↓, LPS↓, Akt↓, GutMicro↑, Imm↑, ChemoSen↑,

Showing Research Papers: 1 to 50 of 82
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 82

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 4,   GSH↑, 1,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 3,   ROS?, 1,   ROS↓, 1,   ROS↑, 14,   ROS⇅, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ATP↓, 1,   i-ATP↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   NADPH↓, 1,   p‑PKM2↓, 1,   SCD1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 2,   Apoptosis↑, 14,   BAX↑, 8,   BAX⇅, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-xL↓, 1,   BIM↓, 1,   Casp↑, 4,   Casp10↑, 1,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 6,   DR5↑, 2,   Fas?, 1,   Fas↑, 2,   GranA↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 6,   MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   p38↓, 1,   Perforin↓, 1,   Pyro↑, 1,   sFasL↑, 1,   survivin↓, 4,   TNFR 1↑, 1,   TRAILR↑, 1,   XIAP↓, 4,   YAP/TEAD↓, 2,   p‑YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   EGFR↓, 3,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 2,   MEK↓, 1,   MOB1↓, 1,   mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 7,   PI3K/Akt↓, 1,   PI3K/Akt↑, 1,   PKCδ↓, 1,   Raf↓, 1,   RAS↓, 1,   RCC1↓, 1,   Sp1/3/4↓, 2,   STAT3↓, 6,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   cMyc↓, 3,   p‑cMyc↑, 1,   DNMTs↓, 1,   EZH2↓, 1,   HATs↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   miR-124-3p↓, 1,   miR-34a↓, 1,   other↓, 2,   other↑, 1,   other↝, 3,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

i-CRT↓, 1,   ER Stress↑, 3,   HSP27↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 4,   hTERT/TERT↓, 2,   P53↑, 8,   cl‑PARP↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 4,   Telomerase↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 4,   CDK4↑, 1,   CDK6↓, 2,   CDK6↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   Ki-67↓, 3,   P21↑, 7,   p27/CDKN1B↑, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   TumCCA↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cMYB↓, 1,   CSCs↓, 2,   IGF-1↓, 1,   Ki-67↓, 3,   NICD↓, 1,   NOTCH1↓, 5,   TAZ↓, 1,   TumCG↓, 8,   TumCP↓, 12,   TumCP∅, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AP-1↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↓, 2,   COL3A1↓, 1,   decorin↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   EMT↓, 9,   Galectin-9↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 9,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 4,   N-cadherin↓, 1,   NFAT↑, 1,   PDGF↓, 1,   PGF↓, 1,   Slug↓, 2,   Snail↓, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 6,   TumMeta↓, 4,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 9,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   GLUT1↓, 1,   MMP↓, 6,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD25+↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 2,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 9,   COX2/PTGS2↓, 8,   CXCL12↓, 1,   CXCL9↓, 2,   CXCR4↓, 2,   DCells↑, 3,   FOXP3↓, 1,   FoxP3+↓, 1,   GNLY↓, 1,   HCAR2↑, 1,   i-HMGB1↓, 1,   IFN-γ↓, 20,   IFN-γ↑, 19,   IL1↓, 1,   IL1↑, 2,   IL10↓, 3,   IL10↑, 3,   IL12↑, 4,   IL13↓, 1,   IL15↑, 1,   IL17↑, 1,   IL1β↓, 9,   IL2↓, 4,   IL2↑, 6,   IL4↓, 4,   IL4↑, 2,   IL5↓, 1,   IL6↓, 11,   IL6↑, 2,   IL8↓, 3,   Imm↑, 7,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 9,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP-1β↓, 1,   NF-kB↓, 10,   NF-kB↑, 3,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 1,   PD-1↓, 1,   PD-1↑, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PD-L2↓, 1,   PGE2↓, 2,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 1,   T-Cell↑, 3,   Th1 response?, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 14,   TNF-α↑, 3,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER-α36↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 12,   CYP1A1↓, 1,   DDS↑, 1,   Dose↝, 11,   eff↓, 1,   eff↑, 10,   eff↝, 1,   MDR1↓, 3,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 3,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BG↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 3,   EZH2↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 11,   IL6↑, 2,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 4,   Pain↓, 1,   PFS↑, 1,   QoL↑, 2,   radioP↑, 2,   Risk↓, 2,   toxicity↓, 2,   TumVol↓, 4,   TumW↓, 3,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 344

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 23,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 8,   GSH↑, 12,   GSR↑, 2,   GSTs↑, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↑, 10,   Keap1↓, 1,   lipid-P↓, 13,   MDA↓, 8,   MPO↓, 5,   NQO1↑, 1,   NRF2↑, 14,   ROS?, 1,   ROS↓, 20,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 3,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 1,   ATP↓, 1,   ATP↑, 2,   GSK‐3β↓, 2,   LDL↓, 5,   NAD↓, 1,   SCFAs↑, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 1,   p‑ERK↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 3,   HDAC↓, 2,   OCT4↓, 1,   other↓, 1,   other↑, 1,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSPs↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   RAD51↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   AP-1↑, 1,   MMP-10↝, 1,   MMP9↓, 2,   MUC1↑, 2,   TGF-β↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   Hif1a↓, 1,   NO↓, 7,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   CLDN1↑, 2,   CLDN3↑, 1,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 4,   MMP↑, 2,   MUC2↑, 1,   OATPs↓, 1,   OCLN↑, 3,   TJ↑, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD25+↓, 1,   CD4+↑, 3,   CD69↓, 1,   COX2/PTGS2↓, 11,   CTLA-4↓, 1,   CXCc↓, 2,   Eos↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 27,   IFN-γ↑, 14,   IFN-γ↝, 1,   IFN-γ∅, 1,   IgE↓, 3,   IgG1↓, 1,   IL1↓, 1,   IL10↓, 4,   IL10↑, 7,   IL10∅, 1,   IL12↓, 2,   IL13↓, 2,   IL13↑, 1,   IL17↓, 9,   IL17↑, 1,   IL17∅, 1,   IL18↓, 1,   IL1β↓, 14,   IL2↓, 6,   IL2↑, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 1,   IL4↝, 1,   IL4∅, 1,   IL5↓, 3,   IL5↝, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↓, 1,   Imm↑, 4,   Inflam↓, 30,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 17,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 3,   PGE2↓, 8,   RANTES↓, 1,   Th2↓, 1,   TLR2↓, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 24,   TNF-α↑, 5,   TNF-α↝, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↓, 1,   BDNF↑, 1,   BrainVol↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 2,   Aβ↓, 5,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 13,   BioAv↝, 2,   Dose↝, 8,   eff↑, 4,   Half-Life↓, 1,   Half-Life↑, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   AST↓, 9,   BP↓, 1,   BP↝, 1,   creat↓, 1,   CRP↓, 3,   FEV1↑, 1,   IL6↓, 22,   IL6↑, 1,   IRes↓, 1,   NLR↓, 1,   PEF↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 5,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 4,   neuroP↑, 10,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 4,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 8,   toxicity↝, 3,   Weight↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 255

Scientific Paper Hit Count for: IFN-γ, Interferon-γ
7 Thymoquinone
6 Silymarin (Milk Thistle) silibinin
4 immunotherapy
3 Quercetin
2 Açaí, Euterpe oleracea
2 5-fluorouracil
2 Astaxanthin
2 chitosan
2 Curcumin
2 Chlorella (Chlorella vulgaris)
2 Spirulina(Arthrospira/Limnospira)
2 Docosahexaenoic Acid
2 Emodin
2 Hydrogen Gas
2 Luteolin
2 Lycopene
2 Magnetic Field Rotating
2 Magnetic Fields
2 Patchouli Oil (Pogostemon cablin)
2 Sulforaphane (mainly Broccoli)
2 Shikonin
1 Astragalus
1 alpha Linolenic acid
1 beta-glucans
1 Berberine
1 Betulinic acid
1 Bifidobacterium
1 Bromelain
1 Boron
1 Black turtle bean
1 Butyrate
1 Caffeine
1 Capsaicin
1 Carvacrol
1 Chrysin
1 Copper and Cu NanoParticles
1 Chemotherapy
1 diet Fermented Foods
1 diet FMD Fasting Mimicking Diet
1 Electrical Pulses
1 eicosapentaenoic acid
1 Flaxseed Oil
1 Cisplatin
1 Gallic acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginger/6-Shogaol/Gingerol
1 Honokiol
1 Rapamycin
1 Linalool
1 mebendazole
1 gefitinib, erlotinib
1 Mangiferin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 Nimbolide
1 Propolis -bee glue
1 Phycocyanin
1 Piperine
1 Selenium
1 Salvia miltiorrhiza
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:442  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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