Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

6461-

1,8-Cin,

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

-

Review,

AD,

NA

-

Review,

Var,

NA

*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

-

in-vitro,

HCC,

HepG2

TumCP↓, ROS↑, NRF2↑, BAX↑, P53↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

T47D

Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP/DDIT3↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

7426-

AgNPs,

CS,

Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

-

in-vitro,

Pca,

PC3

0.85 μg/mL

-

in-vitro,

Lung,

A549

 0.94 μg/mL

*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

334-

AgNPs,

Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53

-

in-vitro,

Colon,

HCT116

Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

-

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

324-

AgNPs,

CPT,

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

363-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, lipid-P↑, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, JNK↑,

359-

AgNPs,

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

-

in-vitro,

Lung,

A549

 9.87ug/ml

-

in-vitro,

Nor,

HEK293

111.3ug/ml

normal cells

Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,

346-

AgNPs,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

-

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

-

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

350-

AgNPs,

Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells

-

in-vitro,

BC,

MCF7

 40ug/mL

ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

351-

AgNPs,

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

-

in-vitro,

BC,

MCF7

 5ug/mL

-

in-vitro,

BC,

T47D

Casp9↑, Casp3↑, Casp7↑, Bcl-2↓,

397-

AgNPs,

GEM,

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

-

in-vitro,

Ovarian,

A2780S

50 nM GEM, 50 nM AgNPs

6nm

P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

-

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

2660-

AL,

Allicin: A review of its important pharmacological activities

-

Review,

AD,

NA

-

Review,

Var,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,

5168-

AL,

Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells

-

in-vitro,

Var,

NA

TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

-

in-vitro,

ESCC,

Eca109

 0-100ug/ml

-

in-vitro,

ESCC,

EC9706

-

in-vivo,

NA,

NA

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

241-

AL,

Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells

-

in-vitro,

neuroblastoma,

SK-N-SH

 5 μmol/l

 (0, 0.5, 1, 5, 10, and 20 Î¼mol/l) of allicin for 12, 24, and 48 h

Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

3448-

ALA,

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

-

in-vitro,

Nor,

NA

*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,

3549-

ALA,

Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia

-

Review,

AD,

NA

*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,

3550-

ALA,

Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

-

Review,

AD,

NA

*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,

3541-

ALA,

Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology

-

Review,

Var,

NA

*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

Var,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

-

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

267-

ALA,

α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

-

vitro+vivo,

Lung,

A549

 1.5 mM LA for 24 h

-

vitro+vivo,

Lung,

PC9

Apoptosis↑, ROS↑, PDK1 / PDPK1↓, NRF2↓, PDK1 / PDPK1↓, Bcl-2↓, Casp9↑, Dose∅,

7399-

Amla,

Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)

-

Review,

Var,

NA

*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,

1078-

And,

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

-

in-vitro,

BC,

MDA-MB-231

5, 10, 25 and 50 μM

20uM

-

in-vitro,

Nor,

HUVECs

50uM

-

in-vivo,

BC,

MCF7

35uM

xenografts nude mice

-

in-vitro,

BC,

T47D

32uM

-

in-vitro,

BC,

BT549

23uM

-

in-vitro,

BC,

MDA-MB-361

31uM

TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

1009-

And,

5-FU,

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

-

in-vivo,

CRC,

HCT116

-

in-vitro,

CRC,

SW480

ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

6396-

ANE,

FEO,

Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis

-

in-vitro,

Pca,

PC3

TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27/CDKN1B↑, NF-kB↓, eff↑,

6398-

ANE,

trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells

-

in-vitro,

OS,

MG63

*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,

584-

Api,

Cisplatin,

Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

-

in-vivo,

Var,

NA

Eighty Swiss albino male mice

Beclin-1/ATG6↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,

310-

Api,

Apigenin inhibits renal cell carcinoma cell proliferation

-

vitro+vivo,

RCC,

ACHN

 5-80 uM

39.4 μM for 24 h; 15.4 μM for 48 h

 5, 10 and 20 uM

-

in-vitro,

RCC,

786-O

 39.1 μM for 24 h; 19.0 μM for 48 h

-

in-vitro,

RCC,

Caki-1

 50.9 μM for 24 h; 21.4 μM for 48 h

-

in-vitro,

RCC,

HK-2

 122.1 μM for 24 h; 70.2 μM for 48 h

TumCCA↑, p‑ATM↑, p‑CHK1↑, p‑CDC25↑, p‑cDC2↑, P53↑, BAX↑, Casp9↑, Casp3↑,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

-

in-vitro,

Lung,

H1299

 20 uM

-

in-vitro,

Lung,

H460

-

in-vitro,

Lung,

A549

 40 uM

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Lung,

H2030

-

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

270-

Api,

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK

-

in-vivo,

AML,

U937

 20-40 uM (12/24h)

Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,

173-

Api,

Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

-

in-vitro,

Colon,

HCT116

 25, 50 uM

CycB/CCNB1↓, cDC2↓, CDC25↓, P53↑, P21↑, cl‑PARP↑, proCasp8↓, proCasp9↓, proCasp3↓,

416-

Api,

In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

-

vitro+vivo,

MM,

NA

20 mg/kg (C57BL/6 mice, oral gavage)

Malignant mesothelioma (MM)

Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,

2632-

Api,

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

-

in-vitro,

EC,

NA

 20–60 μM

45.55 μM

TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP/DDIT3↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

-

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP/DDIT3↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

2639-

Api,

Plant flavone apigenin: An emerging anticancer agent

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,

2640-

Api,

Apigenin: A Promising Molecule for Cancer Prevention

-

Review,

Var,

NA

chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, Synergy↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

Showing Research Papers: 1 to 50 of 550
Page 1 of 11 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 550

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↑, 2, NA⇅, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 2, antiOx↑, 7, antiOx⇅, 1, ARE↓, 1, Catalase↓, 14, Catalase↑, 7, Copper↑, 1, Fenton↑, 2, frataxin↑, 1, GCLC↑, 1, GCLM↓, 1, GCLM↑, 1, GPx↓, 5, GPx↑, 3, GPx4↓, 5, GSH↓, 40, GSH↑, 9, GSH/GSSG↓, 4, GSR↑, 3, GSS↑, 1, GSSG↓, 1, GSSG↑, 1, GSTs↓, 1, GSTs↑, 2, H2O2↓, 1, H2O2↑, 8, i-H2O2↑, 1, HO-1↓, 7, HO-1↑, 13, HO-1↝, 1, HO-2↓, 1, Iron↑, 1, Keap1↓, 1, lipid-P↓, 8, lipid-P↑, 13, lipid-P↝, 1, MDA↓, 5, MDA↑, 5, MPO↓, 2, NADPH/NADP+↓, 1, NOX4↑, 1, NQO1↓, 1, NQO1↑, 2, Nrf1↑, 1, NRF2↓, 16, NRF2↑, 23, p‑NRF2↓, 1, p‑NRF2↑, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, ROS?, 3, ROS↓, 26, ROS↑, 263, ROS⇅, 10, ROS↝, 2, ROS∅, 1, i-ROS↓, 1, i-ROS↑, 5, mt-ROS↑, 7, SAM-e↝, 1, SOD?, 1, SOD↓, 15, SOD↑, 8, SOD2↓, 3, SOD2↑, 2, TBARS↑, 2, Thiols↓, 1, Trx↓, 1, Trx1↑, 1, ox-Trx1↑, 1, TrxR↓, 6, TrxR1↓, 3, xCT/SLC7A11↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2, FTL↑, 1, IronCh↑, 3, NCOA4↑, 1, STEAP3↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2, BCR↓, 1, CDC2↓, 8, CDC25↓, 15, CDC25↑, 1, p‑CDC25↑, 1, compI↓, 2, compIII↓, 1, compV↓, 1, EGF↓, 4, ETC↓, 2, ETC↝, 1, Insulin↓, 2, MCU↓, 1, MFN2↓, 1, MFN2↑, 1, mitResp↓, 2, MKK7↓, 1, mtDam↑, 31, OCR↓, 3, OXPHOS↓, 1, mt-OXPHOS↓, 1, PDH↓, 1, PINK1↑, 2, SDH↓, 1, SIRT3↓, 2, SIRT3↑, 3,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6, 5LO↓, 2, p‑ACC↑, 1, ACLY↓, 2, ACSL4↑, 1, ACSL5↑, 2, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALDOA↓, 1, AMP↑, 1, AMPK↓, 1, AMPK↑, 19, AMPK↝, 1, p‑AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 14, ATP↝, 1, CAIX/CA9↑, 1, citrate↓, 1, CPT1A↓, 1, ECAR↝, 1, ENO1↓, 2, FASN↓, 2, FASN↑, 2, FBPase↑, 1, GLS↓, 1, glucoNG↑, 1, glucose↓, 1, GlucoseCon↓, 12, GlutMet↓, 1, Glycolysis↓, 24, GSK‐3β↓, 10, GSK‐3β↑, 6, p‑GSK‐3β↓, 5, p‑GSK‐3β↑, 1, Histones↑, 1, HK1↓, 1, HK2↓, 11, lactateProd↓, 10, lactateProd↑, 1, LDHA↓, 6, LDL↓, 1, NAD↝, 1, NADPH↓, 2, NADPH↑, 2, O-Glc↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 6, PFK↓, 1, PFK1↓, 2, PFK2?, 1, PFK2↓, 2, PFKP↓, 1, PGK1↓, 1, PKM2↓, 4, PKM2∅, 1, PLA2↓, 1, polyA↓, 1, PPP↓, 2, Pyruv↓, 1, p‑S6↓, 1, SAT1↑, 1, SIRT1↓, 5, SIRT1↑, 2, SREBP1/SREBF1↓, 2, SREBP2↓, 1, TCA?, 1, TCA↓, 3, TCA↑, 1, TS↓, 3, Warburg↓, 3, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1, AIF↑, 20, APAF1↑, 18, Apoptosis↓, 9, Apoptosis↑, 286, mt-Apoptosis↑, 4, ASK1↑, 2, BAD?, 1, BAD↓, 4, BAD↑, 20, p‑BAD↓, 1, Bak↓, 1, Bak↑, 16, BAX?, 1, BAX↓, 2, BAX↑, 228, BAX⇅, 1, BAX↝, 1, Bax:Bcl2↓, 1, Bax:Bcl2↑, 54, Bcl-2↓, 227, Bcl-2↑, 6, Bcl-2↝, 1, Bcl-2∅, 1, cl‑Bcl-2↓, 1, Bcl-xL↓, 54, Bcl-xL↑, 2, BID↓, 2, BID↑, 17, p‑BID↓, 1, cl‑BID↑, 3, BIM↑, 5, BNIP3↑, 2, BNIP3↝, 1, BOK↑, 2, Casp↑, 13, Casp↝, 1, Casp10↓, 1, Casp10↑, 3, Casp12?, 1, Casp12↑, 9, Casp12↝, 1, cl‑Casp12↑, 1, Casp2↑, 5, Casp3?, 1, Casp3↓, 7, Casp3↑, 371, Casp3↝, 1, Casp3∅, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 62, cl‑Casp3⇅, 1, proCasp3↓, 3, proCasp3↑, 4, pro‑Casp3↑, 1, CASP4↑, 1, Casp6↓, 1, Casp6↑, 4, Casp7?, 1, Casp7↑, 41, cl‑Casp7↑, 7, Casp8↓, 3, Casp8↑, 122, Casp8↝, 1, Casp8∅, 2, cl‑Casp8↑, 16, proCasp8↓, 2, proCasp8↑, 2, pro‑Casp8↑, 1, Casp9?, 2, Casp9↓, 4, Casp9↑, 432, Casp9↝, 1, Casp9∅, 1, p‑Casp9↑, 2, cl‑Casp9↓, 2, cl‑Casp9↑, 66, proCasp9↓, 4, proCasp9↑, 5, pro‑Casp9↑, 1, CellShr↑, 1, cFLIP↓, 11, Cyt‑c↓, 3, Cyt‑c↑, 184, Cyt‑c↝, 1, Cyt‑c?, 1, Diablo↑, 10, DR5↑, 37, FADD↑, 14, Fas↓, 2, Fas↑, 32, FasL↓, 1, FasL↑, 22, Ferroptosis↑, 5, cl‑GSDME↑, 1, HEY1↓, 1, IAP1↓, 15, IAP2/BIRC3↓, 5, cl‑IAP2/BIRC3↑, 1, ICD↑, 2, iNOS↓, 15, Mcl-1↓, 40, Mcl-1↑, 1, p‑Mcl-1↓, 1, MDM2↓, 11, MDM2↑, 2, MLKL↑, 1, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 8, NAIP↓, 2, Necroptosis↑, 3, necrosis↑, 2, NOXA↑, 7, p38↓, 6, p38↑, 30, p‑p38↓, 4, p‑p38↑, 6, PUMA↑, 6, PUMA↝, 1, Pyro↑, 1, RIP3↑, 3, p‑RIP3↑, 1, survivin↓, 66, survivin↝, 1, TNFR 1↑, 2, TRAIL↑, 8, TRAILR↑, 2, TumCD↓, 1, TumCD↑, 22, XIAP↓, 35, XIAP↑, 1, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1, Akt?, 1, Akt↓, 121, Akt↑, 8, p‑Akt↓, 43, AKT1↓, 6, Akt2↓, 2, AMPKα↑, 1, BRAF↝, 1, CaMKII ↓, 2, CK2↓, 4, cMET↓, 3, p‑cMET↑, 1, CREB2↓, 1, cSrc↓, 3, EF-1α↓, 1, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 3, ERK↓, 44, ERK↑, 11, p‑ERK↓, 17, p‑ERK↑, 3, p‑ERK⇅, 1, e-ERK↑, 1, FGFR1↓, 3, FGFR2↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 14, Hippo↑, 1, HRAS↓, 2, IGF-1R↓, 8, IKKα↓, 5, IKKα↑, 1, p‑IKKα↓, 1, IκB↑, 1, p‑IκB↓, 3, JAK↓, 3, JAK1↓, 4, JAK1↑, 1, JAK2↓, 9, p‑JAK2↓, 2, JNK↓, 6, JNK↑, 33, p‑JNK↓, 5, p‑JNK↑, 4, cl‑JNK↑, 1, LIMK1↓, 1, MAP2K1/MEK1↓, 1, MAPK↓, 33, MAPK↑, 22, MAPK↝, 2, p‑MAPK↓, 1, p‑MAPK↑, 1, MEK↓, 6, p‑MEK↓, 3, p‑MEK↑, 1, MKK4↓, 1, mTOR↓, 59, mTOR↑, 1, mTOR↝, 2, p‑mTOR↓, 15, mTORC2↓, 3, NRAS↓, 1, p70S6↓, 2, p70S6↑, 1, P70S6K↓, 3, p‑P70S6K↓, 2, P90RSK↓, 1, PDGFR-BB↓, 1, PDGFRA↓, 1, PI3K↓, 87, PI3K↑, 2, p‑PI3K↓, 8, PI3K/Akt↓, 6, PI3K/Akt↝, 1, PI3k/Akt/mTOR↝, 1, PIAS-3↑, 1, PIK3CA↓, 1, PKA↓, 2, PKCδ↓, 8, p‑PKCδ↓, 1, cl‑PKCδ↑, 1, PTEN↓, 1, PTEN↑, 30, PTEN↝, 1, Raf↓, 8, c-Raf↓, 1, RAS↓, 8, RAS↑, 1, RIP1↑, 1, S6K↓, 1, p‑S6K↓, 1, SHP1↓, 1, SHP1↑, 3, Sp1/3/4↓, 5, Src↓, 3, c-Src↓, 1, STAT↓, 2, STAT3↓, 53, STAT3↑, 2, p‑STAT3↓, 15, p‑STAT3↑, 2, STAT5↓, 2, STAT6↓, 1, TK1↓, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2, ATF4↑, 12, ATF4↝, 1, ATFs↑, 1, ChrMod↝, 1, cJun↓, 5, cJun↑, 4, p‑cJun↑, 2, cMyc↓, 33, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 7, DNMT3A↓, 2, DNMTs↓, 5, EZH2↓, 2, FOXM1↓, 1, FOXO↑, 2, FOXO1↑, 4, FOXO3↓, 3, FOXO3↑, 6, FOXO4↑, 1, GATA3↑, 1, H3↑, 2, ac‑H3↑, 1, H4↑, 2, ac‑H4↑, 1, HATs↓, 5, HATs↑, 1, HDAC↓, 15, HDAC1↓, 4, HDAC10↑, 1, HDAC2↓, 2, HDAC3↓, 4, HDAC8↓, 2, HES1↓, 1, miR-106b↓, 1, miR-133a-3p↑, 1, miR-155↓, 3, miR-17↓, 1, miR-195↑, 1, miR-21↓, 6, miR-21↑, 1, miR-221↓, 1, miR-25-5p↓, 1, miR-25-5p↑, 1, miR-27a-3p↑, 1, miR-339-5p↝, 1, miR-34a↓, 2, miR-34a↑, 2, Myc↓, 5, MYCN↓, 1, n-MYC↓, 1, OCT4↓, 9, OCT4↑, 1, other↓, 4, other↑, 6, other↝, 10, PhotoS↑, 2, SALL4↓, 1, SETBP1↓, 1, sonoS↑, 1, SOX2↓, 7, SOX4↓, 1, SOX4↑, 2, SUV39H↓, 2, TCF-4↓, 2, TET3↑, 1, tumCV?, 1, tumCV↓, 98,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3, cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 28, cl‑CHOP/DDIT3↑, 1, CUL1↝, 1, CUL5↝, 1, eIF2α↓, 1, eIF2α↑, 9, p‑eIF2α↓, 1, p‑eIF2α↑, 2, ER Stress↓, 2, ER Stress↑, 52, GRP78/BiP?, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 19, GRP94↑, 2, HSF1↓, 1, HSP27↓, 7, HSP27↝, 1, HSP70/HSPA5↓, 4, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 11, HSP90↑, 1, HSPs↓, 1, IRE1↑, 6, PDI↑, 1, PERK↑, 10, p‑PERK↑, 1, SERPINH1/HSP47↓, 1, UPR↑, 7, XBP-1↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1, ATG5↑, 9, ATG5↝, 1, ATG7↑, 2, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 20, Beclin-1/ATG6↝, 1, CTSB↓, 2, CTSD↓, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 4, LC3A↑, 3, LC3B↑, 2, LC3B-II↑, 5, LC3I↑, 1, LC3II↓, 1, LC3II↑, 7, LC3s↑, 2, MitoP↑, 2, p62↓, 5, p62↑, 3, PARK2↑, 2, SESN2↑, 1, TumAuto↑, 42,

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1, ATM↑, 3, p‑ATM↑, 2, ATR↑, 1, p‑BRCA1↑, 1, DFF45↓, 2, DFF45↑, 2, DNA-PK↑, 2, DNAdam↓, 2, DNAdam↑, 81, DNArepair↓, 2, DNArepair↑, 1, ERCC1↓, 1, ERCC4/XPF↓, 1, hTERT/TERT↓, 14, Ku70/XRCC6↓, 1, MGMT↓, 2, p16↑, 3, P53?, 1, P53↓, 3, P53↑, 122, P53∅, 1, p‑P53↓, 1, p‑P53↑, 5, p53 Wildtype↓, 1, PARP↓, 4, PARP↑, 40, PARP↝, 1, p‑PARP↑, 1, cl‑PARP↓, 3, cl‑PARP↑, 128, cl‑PARP∅, 1, PARP1↑, 2, cl‑PARP1↑, 3, PCNA↓, 28, RAD51↓, 1, SIRT6↑, 1, Telomerase↓, 15, TOP1↓, 2, TOP2↓, 4, TP53↑, 1, UHRF1↓, 1, γH2AX↑, 11, γH2AX↝, 1, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 16, CDK1↑, 4, p‑CDK1↑, 1, CDK2↓, 38, CDK2↑, 3, p‑CDK2↓, 1, CDK4↓, 46, CDK4↑, 3, p‑CDK4↓, 1, CDK6↓, 19, CDK6↑, 2, CDK8↓, 1, CHK1↓, 2, CHK1↑, 1, p‑CHK1↑, 1, Chk2↓, 2, Chk2↑, 1, ChrCon↑, 2, Cyc↓, 2, cycA1/CCNA1↓, 13, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 34, CycB/CCNB1↑, 3, cycD1/CCND1↓, 81, cycD1/CCND1↑, 3, p‑cycD1/CCND1↓, 1, CycD3↓, 4, cycE/CCNE↓, 25, cycE/CCNE↑, 1, cycE1↓, 1, E2Fs↓, 3, Ki-67↓, 16, mitA↑, 1, p19↑, 1, P21?, 1, P21↓, 4, P21↑, 82, p27/CDKN1B↓, 1, p27/CDKN1B↑, 33, pRB↑, 1, p‑pRB↓, 2, RB1↑, 1, p‑RB1↓, 4, Securin↓, 1, TumCCA?, 1, TumCCA↓, 10, TumCCA↑, 193, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, ALDH↓, 3, ALDH1A1↓, 2, BMP7/OP1↓, 1, BMPs↑, 1, CD133↓, 7, CD24↓, 2, CD34↓, 1, CEBPA↑, 1, cFos↓, 5, cMYB↓, 1, CSCs↓, 28, Diff↓, 1, Diff↑, 3, FGF↓, 4, Gli↓, 1, Gli1↓, 4, HH↓, 3, IGF-1↓, 8, IGF-2↓, 1, IGFBP3↑, 3, JAG1↓, 1, Jun↓, 1, p‑Jun↑, 1, Ki-67↓, 16, Let-7↑, 3, mTORC1↓, 5, p‑mTORC1↓, 1, Nanog↓, 7, Nanog↑, 1, Nestin↓, 3, NICD↓, 1, NOTCH↓, 11, NOTCH1↓, 10, NOTCH1↑, 1, NOTCH3↓, 2, OGFr↑, 2, PTCH1↓, 1, SCF↓, 1, Shh↓, 5, Smo↓, 3, STAT1↓, 1, TAZ↓, 1, TumCG?, 2, TumCG↓, 72, TumCG↑, 3, TumCP↓, 131, TumCP↑, 3, tyrosinase↓, 1, URGCP/URG4↓, 1, Wnt?, 1, Wnt↓, 26, Wnt/(β-catenin)↓, 6, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg?, 1, AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 11, AP-1↑, 1, BACH1↓, 1, Ca+2↓, 6, Ca+2↑, 45, Ca+2↝, 4, i-Ca+2↑, 4, mt-Ca+2↑, 1, CAFs/TAFs↓, 1, cal2↑, 4, CCN2/CTGF↓, 1, Cdc42↑, 1, COL1↓, 2, COL3A1↓, 1, DLC1↑, 3, E-cadherin↓, 8, E-cadherin↑, 40, EM↑, 1, EMT↓, 51, EMT↑, 2, EMT↝, 1, EpCAM↓, 1, FAK↓, 16, p‑FAK↓, 2, Fibronectin↓, 1, FOSB↑, 1, GLI2↓, 1, IQGAP3↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB3↓, 1, ITGB4↓, 1, KRAS↓, 1, LAMs↓, 1, LEF1↓, 1, MALAT1↓, 1, MMP1↓, 5, MMP13↓, 3, MMP2↓, 78, MMP3↓, 5, MMP7↓, 9, MMP9↓, 90, MMP9↑, 1, MMPs↓, 27, MUC4↓, 1, N-cadherin↓, 29, p‑p44↓, 1, PDGF↓, 4, proline↓, 1, Rac1↓, 1, Rho↓, 2, ROCK1↓, 2, Slug?, 1, Slug↓, 11, Smad1↓, 1, SMAD2↓, 1, p‑SMAD2↓, 1, SMAD3↓, 3, SMAD3↑, 1, p‑SMAD3↓, 1, SMAD4↓, 1, p‑SMAD4↓, 2, Snail?, 1, Snail↓, 25, TET1↓, 1, TET1↑, 4, TGF-β↓, 16, TGF-β↑, 3, TIMP1↓, 2, TIMP1↑, 8, TIMP2↓, 3, TIMP2↑, 11, TIMP3↑, 1, TRIB3↑, 1, TSP-1↑, 3, TumCA↓, 2, TumCA↑, 1, TumCI↓, 71, TumCI↑, 1, TumCMig↓, 55, TumMeta↓, 47, TumMeta↑, 4, TumPF↓, 2, Twist↓, 17, uPA↓, 21, uPAR↓, 1, Vim↓, 31, Zeb1↓, 11, ZEB2↓, 3, α-tubulin↑, 1, β-catenin/ZEB1↓, 35, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74, angioG↑, 1, CD31/PECAM-1↓, 3, Endoglin↑, 2, HIF-1↓, 4, Hif1a↓, 48, Hif1a↑, 1, NO↓, 3, NO↑, 2, VCAM-1↓, 3, VEGF↓, 82, VEGF↑, 1, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 16,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 2, CLDN2↓, 1, CLDN2↑, 1, CX43/GJA1↓, 1, EPR↑, 3, GLUT1↓, 13, GLUT1↑, 1, GLUT2↓, 1, GLUT3↑, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 193, MMP↑, 1, MPT↑, 8, NHE1↓, 1, TRPM7↓, 1, TRPV1↑, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD4+↓, 1, CD4+↑, 2, CD44↓, 12, CD8+↑, 1, cDC2↓, 2, p‑cDC2↑, 1, COX1↓, 1, COX2/PTGS2↓, 71, CXCL1↓, 2, CXCL12↓, 1, CXCR2↓, 1, CXCR4↓, 13, CXCR4↑, 1, DR4↑, 8, DR4∅, 1, FOXP3↓, 1, FOXP3↑, 1, HLA-I/II↑, 1, HMGB1↓, 2, ICAM-1↓, 4, IFN-γ↓, 3, IFN-γ↑, 2, Igs↓, 1, IL1↓, 4, IL10↓, 3, IL12↓, 2, IL12↑, 1, IL17↓, 1, IL1β↓, 14, IL2↓, 2, IL2↑, 2, IL4↓, 1, IL6↓, 33, IL8↓, 6, Imm↑, 9, Imm↝, 2, Inflam↓, 29, pol-M1↑, 1, MCP1/CCL2↓, 4, MCT1↓, 1, NAF1↓, 1, NF-kB↓, 121, NF-kB↑, 4, p‑NF-kB↓, 2, p‑NF-kB↑, 2, NK cell↑, 3, NLRP3↑, 1, p50↓, 2, p65↓, 7, PD-1↓, 1, PD-L1↓, 3, PGE2↓, 19, PSA↓, 7, RAGE↓, 2, SOCS-3↓, 1, T-Cell↑, 2, T-Cell↝, 1, Th1 response↑, 2, Th17↑, 1, TLR4↓, 3, TNF-α↓, 30, TNF-α↑, 5, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2, TRADD↑, 1, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, AR↓, 11, ER-α36↓, 1, ER(estro)↓, 1, PPARα↓, 1, cl‑PPARα↓, 1, PPARγ↓, 2, PPARγ↑, 2, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, AKR1B10↓, 1, BioAv↓, 30, BioAv↑, 32, BioAv↝, 5, BioEnh↑, 4, ChemoSen?, 2, ChemoSen↓, 3, ChemoSen↑, 112, ChemoSen↝, 1, CompStab↑, 3, CompStab↝, 2, CYP1A1↓, 2, CYP1A1↑, 1, CYP1B1↑, 1, CYP3A4↓, 2, DDS↑, 1, Dose?, 5, Dose↓, 4, Dose↑, 9, Dose⇅, 1, Dose↝, 43, Dose∅, 7, eff↓, 77, eff↑, 68, eff↝, 8, eff∅, 1, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 10, MDR1↓, 4, MRP1/ABCC1↓, 2, MRP1/ABCC1↝, 1, P-gp/ABCB1↓, 13, P450↓, 4, RadioS↑, 37, selectivity?, 1, selectivity↓, 2, selectivity↑, 88, Synergy?, 1, Synergy↑, 76, TET2↓, 1, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALP↝, 1, AR↓, 11, AST↓, 2, AST↑, 1, AST↝, 1, BRAF↝, 1, p‑BRCA1↑, 1, CEA↓, 1, CRP↓, 1, E6↓, 1, E7↓, 1, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 3, EZH2↓, 2, FOXM1↓, 1, HER2/EBBR2↓, 14, hTERT/TERT↓, 14, IL6↓, 33, KRAS↓, 1, LDH↓, 5, LDH↑, 5, LDH↝, 2, Myc↓, 5, PD-L1↓, 3, PSA↓, 7, RAGE↓, 2, TG/TAG↓, 1, TP53↑, 1, TRIB3↑, 1, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 44, antiD↑, 1, antiNeop↑, 1, AntiTum↑, 23, cachexia↓, 2, cardioP↑, 5, CardioT↑, 1, chemoP↑, 24, chemoPv↑, 18, chemoPv⇅, 1, ChemoSideEff↓, 5, cognitive?, 1, hepatoP↓, 1, hepatoP↑, 7, neuroP↑, 2, NP/CIPN↓, 1, OS↑, 8, Pain↓, 2, PFS↓, 1, Pin1↓, 2, QoL↑, 4, QoL∅, 1, radioP↑, 6, RenoP↑, 9, Risk↓, 9, Strength↑, 1, toxicity↓, 11, toxicity↑, 4, toxicity↝, 4, toxicity∅, 1, TumVol↓, 24, TumVol↑, 1, TumW↓, 13, Weight↑, 2, Weight∅, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, Bacteria↓, 2, GutMicro↑, 2, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↝, 7,
Total Targets: 1025

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5, antiOx↑, 78, ARE↑, 1, Catalase↓, 1, Catalase↑, 38, Fenton↓, 1, GPx↑, 30, GSH↑, 38, GSR↓, 1, GSR↑, 4, GSTs↓, 2, GSTs↑, 10, H2O2↓, 2, HDL↑, 2, HO-1↓, 2, HO-1↑, 15, Keap1↓, 2, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 29, MDA↓, 28, MPO↓, 3, NADH↓, 1, NOX↓, 1, NOX4↓, 1, NQO1↑, 2, NRF2↓, 1, NRF2↑, 35, Prx↑, 1, RNS↓, 4, ROS↓, 95, ROS↑, 3, ROS∅, 1, mt-ROS?, 1, SOD↓, 2, SOD↑, 46, SOD1↑, 1, SOD2↑, 1, TAC↑, 3, TBARS↓, 3, Trx↑, 1, uricA↓, 1, VitC↑, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2, IronCh↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1, FIS1↓, 1, Insulin↑, 1, MFN2↑, 1, mitResp↑, 1, mtDam↓, 2, PGC-1α↑, 2, PGC-1α↝, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 1, adiP↑, 1, ALAT↓, 12, AMPK↓, 1, AMPK↑, 5, ATP↓, 2, ATP↑, 7, cAMP↑, 2, DGAT1↓, 1, FASN↓, 1, glucose↓, 3, glucose↝, 1, GlucoseCon↑, 1, GSK‐3β↓, 5, H2S↑, 2, HMG-CoA↓, 1, LDHA↑, 1, LDL↓, 3, lipidLev↓, 3, NAD↓, 1, NAD↑, 1, NADPH↓, 3, NADPH↑, 2, PLA2↓, 1, SIRT1↑, 7,

Cell Death(tgid=5) ⓘ

AIF↓, 2, APAF1↓, 2, Apoptosis↓, 15, Apoptosis↑, 1, Apoptosis∅, 1, ASK1↓, 1, BAX↓, 18, Bax:Bcl2↓, 1, Bax:Bcl2↑, 3, Bax:Bcl2↝, 1, Bcl-2↓, 3, Bcl-2↑, 12, Bcl-xL↑, 1, Casp↓, 1, Casp12↓, 1, Casp3?, 1, Casp3↓, 35, Casp3↑, 3, Casp3∅, 1, cl‑Casp3↓, 3, cl‑Casp3↑, 1, Casp6↓, 1, Casp8↓, 3, Casp8↑, 1, cl‑Casp8↑, 1, Casp9↓, 29, Casp9↑, 4, Casp9∅, 1, cl‑Casp9↓, 4, cl‑Casp9↑, 1, Cyt‑c↓, 11, Cyt‑c∅, 1, Fas↓, 2, Fas↑, 2, FasL↓, 1, GSDMD↓, 1, iNOS↓, 17, iNOS↑, 1, MLKL↓, 1, necrosis↓, 1, p38↓, 2, p‑p38↓, 1, Pyro↓, 1, TUNEL↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5, Akt↑, 6, p‑Akt↓, 1, p‑Akt↑, 1, Akt2↓, 1, CaMKII ↓, 1, CREB↑, 2, ERK↓, 5, ERK↑, 3, p‑ERK↑, 1, HGF/c-Met↑, 1, IKKα↓, 1, IKKα↑, 1, IκB?, 1, JAK↓, 1, JAK2↑, 1, JNK↓, 5, p‑JNK↓, 2, MAPK↓, 8, mTOR↓, 1, mTOR↑, 4, p‑mTOR↓, 1, PDGFR-BB↓, 1, PDGFRB↓, 1, PI3K↓, 5, PI3K↑, 5, PKCδ↓, 1, PKCδ↑, 1, RIP1↓, 1, STAT↓, 1, STAT3↓, 2, STAT3↑, 3, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF4↓, 1, cJun↓, 1, p‑cMyc↑, 1, HDAC↓, 2, HDAC2↓, 1, HDAC3↓, 1, HOTAIR↑, 1, other↓, 2, other↑, 5, other↝, 5, RUNX2↑, 1, tumCV↓, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 1, ER Stress↓, 2, GRP78/BiP↓, 2, GRP78/BiP↑, 2, GRP94↑, 1, HSP27↑, 1, HSP70/HSPA5↑, 1, HSPs↓, 1, HSPs↑, 1, IRE1↓, 1, PERK↓, 1, UPR↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4, Beclin-1/ATG6↑, 2, LC3II↓, 1, LC3II↑, 2, p62↓, 1, p62↑, 2, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5, p16↓, 1, P53↓, 5, P53↑, 2, PARP∅, 1, cl‑PARP↓, 1, cl‑PARP↑, 2, PARP1↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, GADD34↓, 1, Ki-67↓, 1, P21↓, 3, P21↑, 2, TumCCA↑, 3,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Diff↝, 1, Ki-67↓, 1, neuroG↑, 1, TumCP↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 3, AP-1↓, 1, Ca+2↓, 1, Ca+2↑, 1, COL1↓, 2, COL1↑, 1, E-cadherin↓, 1, E-cadherin↑, 1, EMT↓, 1, MLC2/MYL9↝, 1, MMP13↓, 2, MMP9↓, 1, p‑Rac1↓, 1, Rho↓, 1, ROCK1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, p‑T-cadherin↓, 1, TGF-β↓, 1, TregCell↑, 1, TumCI↓, 1, TumCMig↓, 1, Vim↓, 1, Zeb1↓, 1, α-SMA↓, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, angioG↑, 1, eNOS↑, 1, Hif1a↓, 4, Hif1a↑, 1, NO↓, 11, NO↑, 1, VCAM-1↓, 2, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 12, GastroP↑, 3, GLUT2↑, 1, GLUT4↑, 1, IBI↑, 1, MMP↓, 3, MMP↑, 10, OCLN↝, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, ZO-1↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1, CD19↑, 1, CD25+↑, 1, CD4+↑, 3, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 26, COX2/PTGS2↑, 1, CXCR4↓, 1, FOXP3↑, 1, HMGB1↓, 1, IFN-γ↓, 2, IL1↓, 1, IL10↓, 6, IL10↑, 4, IL17↓, 2, IL18↓, 2, IL1β↓, 25, IL2↓, 3, IL33↓, 1, IL4↓, 2, IL4↑, 1, IL5↓, 1, IL6↓, 34, IL6↑, 1, IL8↓, 4, Imm↓, 1, Imm↑, 5, INF-γ↓, 2, Inflam↓, 90, Inflam↑, 1, LPS↓, 1, M2 MC↑, 1, pol-M2 MC↑, 1, MCP1/CCL2↓, 2, MyD88↓, 1, NeuroI↓, 2, NF-kB↓, 32, p‑NF-kB↓, 1, NK cell↑, 1, NLRP3↓, 3, PGE2↓, 14, RANTES↓, 1, TLR4↓, 6, TNF-α↓, 45, Treg lymp↝, 1, TRIF↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 3, Ach↑, 1, AChE↓, 12, BChE↓, 4, BDNF↓, 1, BDNF↑, 9, ChAT↑, 2, DA↑, 1, MAOA↓, 2, NGF↑, 2, PSD95↑, 1, SNAP25↑, 1, TPH1↓, 1, TrkB↑, 2,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 13, Aβ42↓, 3, BACE/β-secretase↓, 6, IDE↑, 1, tau↓, 3, p‑tau↓, 2, XO↝, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 5,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 28, BioAv↑, 28, BioAv⇅, 1, BioAv↝, 12, BioEnh↑, 2, CYP2D6↓, 1, CYP2E1↓, 2, Dose↓, 1, Dose↑, 1, Dose⇅, 1, Dose↝, 8, eff↓, 2, eff↑, 6, eff↝, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 2, Half-Life↝, 9, P-gp/ABCB1↓, 2, P450↓, 2, P450↝, 1, selectivity↑, 1, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12, ALB↝, 1, ALP↓, 5, AST↓, 11, BG↓, 1, BloodF↑, 2, BP↓, 5, BUN?, 1, BUN↓, 2, CEA↓, 1, creat↓, 8, CRP↓, 3, hs-CRP↓, 1, IL6↓, 34, IL6↑, 1, LDH↓, 6, NOS2↓, 1, SpO2↑, 1, Urea↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 1, antiAll↑, 13, AntiArt↑, 4, AntiCan↑, 15, antiCG↑, 1, AntiDiabetic↑, 20, antiNeop↑, 1, antiPs↑, 3, AntiTum↓, 2, AntiTum↑, 4, cardioP?, 1, cardioP↑, 33, chemoP↑, 7, chemoPv↑, 1, cognitive↑, 16, diuretic↑, 3, hepatoP↑, 29, Learn↑, 1, memory↑, 12, motorD↑, 4, Mucositis↓, 2, neuroP↓, 1, neuroP↑, 53, Obesity↓, 4, OS↑, 1, Pain↓, 2, radioP↑, 3, RenoP↑, 8, Stroke↓, 4, toxicity?, 1, toxicity↓, 36, toxicity↑, 4, toxicity↝, 6, toxicity∅, 8, Weight↑, 1, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13, AntiFungal↓, 1, AntiFungal↑, 3, AntiP↑, 2, AntiViral↑, 8, Bacteria↓, 15, Diar↓, 2, GutMicro↑, 10, Inf↓, 1, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,
Total Targets: 428

Scientific Paper Hit Count for: Casp9, Caspase-9

21 Quercetin
18 Silver-NanoParticles
18 Baicalein
17 Luteolin
16 Curcumin
16 Thymoquinone
15 Emodin
14 Fisetin
13 Kaempferol
12 Sulforaphane (mainly Broccoli)
11 Apigenin (mainly Parsley)
11 Magnolol
9 Allicin (mainly Garlic)
9 Berberine
9 Betulinic acid
9 Chrysin
9 Morin
8 Honokiol
8 Silymarin (Milk Thistle) silibinin
7 Cisplatin
7 Artemisinin
7 Alpha-Lipoic-Acid
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
6 Citric Acid
6 D-limonene
6 Eugenol
6 Garcinol
6 Graviola
5 Ginkgetin
5 Ivermectin
5 Matrine
5 Phenethyl isothiocyanate
5 Shikonin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Ashwagandha(Withaferin A)
4 Bromelain
4 Boron
4 Capsaicin
4 Carvacrol
4 chaetocin
4 Photodynamic Therapy
4 Radiotherapy/Radiation
4 Formononetin
4 Fucoidan
4 Juglone
4 Licochalcone A
4 Lycopene
4 Magnetic Fields
4 Plumbagin
4 Resveratrol
3 5-fluorouracil
3 Berbamine
3 Boswellia (frankincense)
3 α-Bisabolol / Chamomile oil
3 Carnosic acid
3 Chlorogenic acid
3 Dandelion Root
3 Evodiamine
3 Ferulic acid
3 Gallic acid
3 Geraniol
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Hyperoside
3 Isoliquiritigenin
3 isoorientin
3 Vitexin
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
3 Aflavin-3,3′-digallate
2 Astragalus
2 Andrographis
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Beta-Caryophyllene
2 Brucea javanica
2 Bullatacin
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Polyphenols
2 Deguelin
2 Docetaxel
2 Echinacea
2 Electrical Pulses
2 Paclitaxel/Taxol
2 Hydrogen Gas
2 Chemotherapy
2 Hibiscus sabdariffa
2 Rutin
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoquercitrin
2 lambertianic acid
2 low dose naltrexone
2 Linalool
2 methylseleninic acid
2 Mangiferin
2 doxorubicin
2 Mistletoe/Viscum album Extracts
2 Nimbolide
2 Oleuropein
2 Phycocyanin
2 Rosmarinic acid
2 salinomycin
2 Selenium
2 chitosan
2 Selenite (Sodium)
2 Ursolic acid
1 1,8-Cineole
1 entinostat
1 Camptothecin
1 Resiquimod
1 Gemcitabine (Gemzar)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Fennel Oil/Foeniculum vulgare
1 Metformin
1 2-DeoxyGlucose
1 almonertinib
1 epirubicin
1 Biochanin A
1 Bufalin/Huachansu
1 brusatol
1 borneol
1 Caffeic acid
1 Sorafenib (brand name Nexavar)
1 Celecoxib
1 Chlorophyllin
1 Cinnamon
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Cynaropicrin
1 Diclofenac
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Geldanamycin
1 Radicicol/monorden
1 Flaxseed/Linseed
1 olaparib/LYNPARZA
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Baicalin
1 Indole-3-carbinol
1 Isovitexin
1 L-Theanine
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Melatonin
1 Moringa oleifera
1 Methylsulfonylmethane
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 sericin
1 Propyl gallate
1 topotecan
1 Piperine
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 polyethylene glycol
1 Auranofin
1 Spirulina(Arthrospira/Limnospira)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:45  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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