p27/CDKN1B Cancer Research Results

p27/CDKN1B, p27kip1: Click to Expand ⟱
Source:
Type:
The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

CDKN1B - Cyclin-Dependent Kinase Inhibitor 1B / p27

Abbreviation: CDKN1B, p27, p27Kip1

Type: Cyclin-dependent kinase inhibitor / cell-cycle regulator

Function: CDKN1B/p27 inhibits cyclin-CDK complexes, particularly cyclin E-CDK2 and cyclin A-CDK2, thereby restricting G1/S cell-cycle progression. It also regulates differentiation, transcription, cytoskeletal organization, cell migration, and cellular responses to growth-factor signaling.

Cancer: ↕ Context-dependent, but predominantly tumor-suppressive. Reduced nuclear p27 expression or functional loss can promote uncontrolled proliferation, tumor progression, and treatment resistance. However, cytoplasmic p27 can acquire CDK-independent pro-oncogenic functions that promote cell motility, invasion, and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
9018- 3BP,    C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells
- in-vitro, BC, MDA-MB-231
TumCP↓, Tumccf↓, TumCCA↑, cycD1/CCND1↓, CDK2↓, P21↑, p27/CDKN1B↑, COX2/PTGS2↓, TumCMig↓, Apoptosis↑, MAPK↑, JNK↑, ERK↓, Synergy↑,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
4584- AgNPs,    Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells
- in-vitro, Pca, DU145
selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, AntiCan↑,
347- AgNPs,    The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
- Review, Var, NA
ROS↑, TumCCA↑, ER Stress↑, TumCG↓, TumCP↓, DNAdam↑, P53↑, MMP2↓, MMP9↓, angioG↓, TumMeta↓, MMP↓, Casp3↑, cycD1/CCND1↓, PCNA↓, TNF-α↓, IL6↓, P21↑, p27/CDKN1B↑, CDK2↓, CDK4↓, Fas↑, FADD↑, BAX↑, PUMA↑, Bcl-2↓, Bcl-xL↓, ATP↓, PDK1 / PDPK1↓, Glycolysis↓, Cyt‑c↑, cl‑PARP↑, TRF2↓, hTERT/TERT↓, ETC↓, GSH↓, eff↑, ChemoSen↑, EMT↓,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
261- ALA,    The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells
- in-vitro, BC, MCF7
ROS↓, Akt↓, p27/CDKN1B↑, Bax:Bcl2↑,
263- ALA,    Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines
- in-vitro, SCC, Jurkat - in-vitro, SCC, FaDu
p27/CDKN1B↑,
6396- ANE,  FEO,    Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
- in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27/CDKN1B↑, NF-kB↓, eff↑,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27/CDKN1B↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, Var, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
5171- Ash,    The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry"
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, PC3
Proteasome↓, BAX↑, p27/CDKN1B↑, AR↓, TumCG↓,
4809- ASTX,    Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression
- in-vitro, GC, AGS - in-vitro, GC, MKN45
tumCV↓, TumCP↓, TumCCA↑, p‑ERK↓, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, Var, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27/CDKN1B↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5551- BBM,    Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
- vitro+vivo, Bladder, NA
tumCV↓, TumCP↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, EMT↓, TumMeta↓, p65↓, p‑p65↓, IKKα↓, NF-kB↑, ROS↑, NRF2↓, HO-1↓, SOD2↓, GPx1↓, Bax:Bcl2↑, TumVol↓,
1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, Var, NA
TumCCA↑, TP53↑, COX2/PTGS2↓, Bax:Bcl2↑, ROS↑, VEGFR2/KDR/Flk1↓, Akt↓, ERK↓, MMP2↓, MMP9↓, IL8↑, P21↑, p27/CDKN1B↑, E-cadherin↓, Fibronectin↓, cMyc↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
CSCs↓, TumCP↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, TumCCA↑, Apoptosis↑, ChemoSen↑, β-catenin/ZEB1↓, FTO↑, CD44↓, CD133↓, ChemoSen↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
2753- BetA,    Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells
- in-vitro, Cerv, HeLa
PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27/CDKN1B↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
8703- BMF,    Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
- in-vitro, Var, NA
HMGCR↓, CSCs↓, ALDH↓, STAT3↓, NOTCH↓, Wnt↓, β-catenin/ZEB1↓, OXPHOS↓, FAO↓, selectivity↑, Ingr↝, HMG-CoA↓, Rho↓, p27/CDKN1B↑, mitResp↓, compI↓, compII↓, compIV↓, compV↓, OCR↓, ATP↓,
1450- Bos,  Cisplatin,    3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
- in-vitro, Pca, DU145
ROS↑, MMP↓, Casp↑, Apoptosis↑, Bax:Bcl2↑, TumCCA?, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, NOTCH↓, ChemoSen↑,
5750- CA,    Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells
- in-vitro, MM, NA
eff↑, selectivity↑, Ki-67↓, PCNA↓, TumCP↓, p‑ERK↓, Akt↓, p27/CDKN1B↑, P21↑, TumCCA↑, Bax:Bcl2↑, cl‑Casp3↑, mt-Apoptosis↑,
6640- Cen,    Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells
- in-vitro, HCC, Bel-7402 - in-vitro, HCC, QGY-7703
TumCP↓, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, MAPK↓, ERK↓, P-gp/ABCB1↓, ROS↓, p‑pRB↓, cycD1/CCND1↓, p27/CDKN1B↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6191- Cuc,    Growth inhibitory effect of Cucurbitacin E on breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, Casp3↑, P21↑, p27/CDKN1B↑, ChemoSen↑, STAT3↓,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
459- CUR,    Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, RT4
Trop2↓, Apoptosis↑, cycE1↓, p27/CDKN1B↑, TumCCA↑,
137- CUR,    Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
- in-vitro, Pca, DU145
NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27/CDKN1B↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27/CDKN1B↑, Insulin↓, IGF-1↓,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27/CDKN1B↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
8857- DIM,    Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
Dose↝, TumCCA↑, CDK2↓, E2Fs↓, cycA1/CCNA1↓, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, CDC2↓, CDC25↓,
8838- DIM,    3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, p27/CDKN1B↑, other↝,
8828- DIM,    Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kip
- in-vitro, BC, MCF-10AT - in-vitro, BC, T47D - in-vitro, BC, BT20 - in-vitro, BC, BT474
TumCG↓, p27/CDKN1B↑, Akt↓,
8851- DIM,    3,3’-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs
- Review, Var, NA
Apoptosis↑, NF-kB↓, Akt↓, Wnt↓, PI3K↓, mTOR↓, PSA↓, Let-7↓, miR-34a↓, EZH2↓, NOTCH1↓, AR↓, E-cadherin↑, Zeb1↓, Vim↓, Slug↓, EMT↓, MTA2↓, NF-kB↓, IRAK1↓, EGFR↓, SOX4↓, FOXM1↓, p27/CDKN1B↓, AhR↓, EZH2↓, Wnt↓, PUMA↓, AEG1↑, ROS↑, PPARα↑, CycB/CCNB1↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, Var, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, Cerv, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27/CDKN1B↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27/CDKN1B↑, cycA1/CCNA1↓, cycE/CCNE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,

Showing Research Papers: 1 to 50 of 123
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 2,   antiOx⇅, 1,   ARE↑, 2,   Catalase↓, 2,   Catalase↑, 3,   Copper↑, 1,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 4,   GSTs↑, 1,   HO-1↓, 5,   HO-1↑, 2,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 12,   ROS↑, 55,   ROS⇅, 4,   i-ROS↑, 1,   SOD↓, 3,   SOD↑, 3,   SOD2↓, 2,   TAC?, 1,   TAC↓, 1,   Trx↑, 1,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 3,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 1,   mtDam↑, 3,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   PDH↑, 2,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 1,   ALDOA↓, 1,   AMP↓, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 7,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDHA↓, 4,   LDL↓, 2,   MCT4↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 3,   PFK↓, 2,   PKM2↓, 3,   polyA↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 58,   mt-Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 39,   BAX⇅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 42,   Bcl-2↑, 1,   Bcl-xL↓, 15,   BID↓, 1,   BID↑, 3,   BIM↑, 3,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 12,   Casp1↑, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 45,   cl‑Casp3↑, 8,   Casp7↑, 4,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 25,   Diablo↑, 4,   DR5↓, 1,   DR5↑, 7,   FADD↑, 2,   Fas↑, 7,   FasL↑, 1,   Ferroptosis↑, 2,   iNOS↓, 2,   Mcl-1?, 1,   Mcl-1↓, 8,   MDM2↓, 5,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   oncosis↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   survivin↓, 21,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 4,   XIAP↓, 11,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 53,   Akt↑, 1,   p‑Akt↓, 8,   AKT1↓, 1,   AMPKα↑, 1,   CK2↓, 1,   cMET↓, 2,   EGFR↓, 15,   ERK↓, 23,   p‑ERK↓, 4,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 3,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 1,   JAK2↓, 4,   JNK↓, 3,   JNK↑, 9,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 4,   MEK↓, 1,   mTOR↓, 27,   p‑mTOR↓, 2,   p70S6↓, 1,   P70S6K↓, 3,   PI3K↓, 35,   p‑PI3K↓, 2,   PI3K/Akt↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 3,   RAS↓, 8,   S6K↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 3,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 2,   STAT5↓, 2,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 2,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 14,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 4,   FOXO↑, 3,   FOXO1↓, 1,   FOXO3↓, 3,   FOXO3↑, 3,   H3↓, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   IRF1↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   MTA2↓, 2,   Myc↓, 2,   n-MYC↓, 1,   OCT4↓, 3,   other↑, 1,   other↝, 4,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   IRE1↑, 3,   PERK↑, 2,   Proteasome↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   LC3A↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   p‑ATR↑, 1,   BRCA1↑, 3,   BRCA2↑, 1,   DNAdam↑, 21,   DNArepair↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 5,   P53↓, 2,   P53↑, 38,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 4,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 24,   PARP1↑, 1,   PCNA↓, 10,   RAD51↓, 1,   Telomerase↓, 5,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 37,   CDK2↑, 2,   CDK4↓, 41,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 13,   CDK6↑, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 9,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 62,   cycD1/CCND1↑, 1,   CycD3↓, 4,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   E2F4↑, 1,   E2Fs↓, 4,   Ki-67↓, 4,   P21↓, 7,   P21↑, 88,   p27/CDKN1B↓, 11,   p27/CDKN1B↑, 111,   cl‑p27/CDKN1B↓, 1,   pRB↓, 3,   pRB↑, 2,   p‑pRB↓, 4,   RB1↑, 2,   cl‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 84,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 2,   CSCs↓, 9,   Diff↓, 1,   Diff↑, 4,   EP4/PTGER4↑, 1,   Gli↓, 1,   Gli1↓, 3,   HMGCR↓, 2,   IGF-1↓, 5,   IGFBP3↑, 1,   p‑Jun↓, 1,   Ki-67↓, 4,   Let-7↓, 1,   Let-7↑, 1,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 4,   NOTCH2↓, 1,   NOTCH2↑, 1,   PTCH1↓, 2,   Smo↓, 2,   TumCG↓, 20,   TumCG↑, 1,   TumCP↓, 40,   TumCP↑, 1,   Wnt?, 1,   Wnt↓, 12,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AP-1↓, 5,   CA↓, 1,   Ca+2↑, 7,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 13,   EMT↓, 15,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↑, 1,   LRP1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 2,   MMP7↓, 4,   MMP9↓, 23,   MMP9↑, 1,   MMPs↓, 9,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 5,   NCAM↑, 1,   PDGF↓, 4,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 6,   TGF-β↓, 2,   TIMP2↓, 1,   TIMP2↑, 3,   Trop2↓, 1,   TumCI↓, 12,   TumCMig↓, 15,   TumMeta↓, 14,   TumMeta↑, 2,   Twist↓, 8,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 9,   Zeb1↓, 7,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 10,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 18,   LOX1↓, 2,   NO↓, 2,   NO↑, 3,   VEGF↓, 30,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 30,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 1,   CD44↓, 3,   COX2/PTGS2↓, 19,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 5,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 10,   IL7↓, 1,   IL8↓, 6,   IL8↑, 1,   Imm↑, 2,   Inflam↓, 10,   IRAK1↓, 2,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 50,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 7,   PSA∅, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 11,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AhR↑, 2,   AhR↓, 1,   AR↓, 10,   ER-α36↓, 1,   ER(estro)↓, 1,   GR↑, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 8,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 3,   ChemoSen↑, 34,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   Dose∅, 1,   eff↓, 7,   eff↑, 16,   eff↝, 3,   GSTA1↑, 1,   Half-Life↓, 5,   Half-Life↝, 4,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 3,   RadioS↑, 15,   selectivity↑, 24,   selectivity↝, 1,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 10,   BRCA1↑, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 15,   EZH2↓, 3,   FOXM1↓, 4,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   Maspin↑, 1,   Myc↓, 2,   PD-L1↓, 3,   PSA↓, 7,   PSA∅, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 2,   FTO↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   NKG2D↑, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 5,   TumW↓, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 581

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 6,   GPx↑, 3,   GSH↑, 8,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 2,   Iron∅, 1,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 2,   CRM↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   glyC↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   ERK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   MMP13↓, 1,   PAI-1/SERPINE1↓, 1,   Rho↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 2,   Inflam↓, 12,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 1,   BioAv↝, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   eff↑, 1,   GSTA1↑, 2,   Half-Life↓, 1,   Half-Life↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   BUN↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↓, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 3,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 116

Scientific Paper Hit Count for: p27/CDKN1B, p27kip1
6 Thymoquinone
6 phytic acid, Inositol hexakisphosphate
6 Resveratrol
5 Diindolylmethane
5 Lycopene
4 Berberine
4 Indole-3-carbinol
4 Fisetin
3 Alpha-Lipoic-Acid
3 Curcumin
3 EGCG (Epigallocatechin Gallate)
3 Gallic acid
3 Sulforaphane (mainly Broccoli)
3 Propolis -bee glue
2 Silver-NanoParticles
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalein
2 Cucurbitacin
2 diet Methionine-Restricted Diet
2 Eugenol
2 HydroxyTyrosol
2 Inositol
2 Phenethyl isothiocyanate
2 lambertianic acid
2 Linalool
2 Luteolin
2 Silymarin (Milk Thistle) silibinin
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Cisplatin
1 Caffeic acid
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Emodin
1 Ferulic acid
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperoside
1 Isoliquiritigenin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Magnolol
1 mebendazole
1 Dordaviprone; Modeyso
1 methylseleninic acid
1 Metformin
1 Melatonin
1 Methylsulfonylmethane
1 Naringin
1 Oleuropein
1 Propyl gallate
1 Plumbagin
1 Quercetin
1 Rosmarinic acid
1 salinomycin
1 Turmerones
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:468  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page