MAOA Cancer Research Results

MAOA, Monoamine Oxidase A: Click to Expand ⟱
Source:
Type: gene/enzyme
Also known as MAO-A, or "Warrior Gene"(associated with increased aggression and impulsivity). This enzyme plays a crucial role in the breakdown of various neurotransmitters, such as serotonin, dopamine, and norepinephrine.
MAOA is commonly overexpressed in prostate cancer, and others.
-MAO-A inhibitors have been proven to be effective antidepressantn
Scientific Papers found: Click to Expand⟱
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↑, *PI3K↑, *Akt↑, *mTOR↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3637- Cro,    Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
- NA, AD, NA
*cognitive∅, *MAOA↓, *MDA↓, *GSH↑, *AChE↓,
1616- CUR,  EA,    Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid
- in-vitro, Nor, NA
*MAOA↓, *Dose∅, Dose?,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
CAFs/TAFs↓, EMT↓, ROS↓, CXCR4↓, IL6↓, MAOA↓, mTOR↓, HIF-1↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6378- Eug,    Effects of Eugenol on the Central Nervous System: Its Possible Application to Treatment of Alzheimer's Disease, Depression, and Parkinson's Disease
- Review, AD, NA
*other↑, *Aβ↓, *BDNF↑, *MAOA↑, *toxicity↓, *Ca+2↓, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑, *PGE2↓, *COX2↓, *5LO↓,
6377- Eug,    Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review
- Review, Var, NA - Review, AD, NA
*Inflam↓, *Bacteria↓, ChemoSen↑, *selectivity↑, ROS⇅, TumCG↓, MMP↓, antiOx⇅, *antiOx↑, *BBB↑, *neuroP↑, *BDNF↑, *Aβ↓, *Ca+2↓, *5LO↓, *MAOA↓, other↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27↑, NF-kB↓, COX2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
3943- Shank,    Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach
- Review, AD, NA
*neuroP↑, *memory↑, *other↝, *AChE↓, *MAOA↓, *MAOB↓, *TrkB↓, *tau↓, *APP↓, *ROS↓, *Mood↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   ROS↓, 1,   ROS↑, 1,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   MAPK↓, 1,   p27↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   EMT↓, 2,   mTOR↓, 2,   PI3K↓, 2,   TumCG↓, 1,  

Migration ⓘ

CAFs/TAFs↓, 1,   E-cadherin↑, 1,   MMPs↓, 2,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

HIF-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 2,  

Synaptic & Neurotransmission ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 3,   Dose?, 1,   eff↓, 1,   Half-Life↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 59

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 3,   antiOx↑, 7,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 2,   lipid-P↓, 5,   MDA↓, 2,   NRF2↑, 3,   RNS↓, 3,   ROS↓, 11,   SOD↓, 1,   SOD↑, 3,   Thiols↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   iNOS↓, 2,   MAPK↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   other↑, 1,   other↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 2,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 2,   VGSC↓, 1,  

Migration ⓘ

5LO↓, 3,   AntiAg↑, 1,   APP↓, 2,   Ca+2↓, 2,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL1β↓, 4,   IL6↓, 2,   Inflam↓, 6,   Inflam↑, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 7,   AChE↑, 1,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 12,   MAOA↑, 1,   MAOA↝, 1,   tau↓, 1,   p‑tau↓, 2,   TrkB↓, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 2,   MAOB↓, 3,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   Dose↝, 1,   Dose∅, 1,   eff↑, 3,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

chemoPv↑, 1,   cognitive↑, 2,   cognitive∅, 1,   memory↑, 6,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 11,   Pain↓, 1,   Risk↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 88

Scientific Paper Hit Count for: MAOA, Monoamine Oxidase A
4 Eugenol
2 Berberine
2 Crocetin
2 Curcumin
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Ellagic acid
1 Shankhpushpi
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:472  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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