SAPK Cancer Research Results

SAPK, stress-activated protein kinases: Click to Expand ⟱
Source:
Type:
SAPK relay, amplify and integrate signals, mainly associated with cellular stress, to allow cell adaptation. p53 and the SAPK pathways are frequently co-compromized in human cancer cells.
Scientific Papers found: Click to Expand⟱
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, PC, DU145 - in-vitro, PC, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓, AR↓, TumCG↓, MEK↑, SAPK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↑, 1,  

Cell Death ⓘ

p‑JNK↓, 1,  

DNA Damage & Repair ⓘ

SAPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   TumCG↓, 1,  

Migration ⓘ

MUC1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p65↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SAPK, stress-activated protein kinases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:494  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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