lysoMP Cancer Research Results

lysoMP, lysosomal membrane permeabilization: Click to Expand ⟱
Source:
Type:
Different forms of stress can induce lysosomal membrane permeabilization (LMP), resulting in the translocation to the cytoplasm of intralysosomal components, such as cathepsins, inducing lysosomal-dependent cell death (LDCD).
Lysosomes are single-membrane cell organelles, the main cellular function of which is to degrade extracellular material internalized by endocytosis/phagocytosis. It is now clear that lysosomes are more than a cellular “suicide bag.” Multiple pathways converge in this organelle, including endocytosis/phagocytosis, autophagy and exocytosis, and lysosomes are key players in several types of cell death. The best-studied mechanism by which LDCD is induced is ROS-mediated lysosomal destabilization.
Lysosomal membrane permeabilization (LMP) refers to the disruption of the lysosomal membrane, leading to the release of lysosomal contents, including hydrolytic enzymes, into the cytoplasm. This process can have significant implications for cellular homeostasis, apoptosis, and cancer biology.

Lysosomal membrane permeabilization is a critical event in cancer biology, often associated with tumor progression and poor prognosis. Increased LMP can promote protumorigenic processes, while maintaining lysosomal integrity may have protective effects against cancer development.


Scientific Papers found: Click to Expand⟱
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, TumCMig↓, Bak↑, GADD45A↑, LTA/TNF-β↑, lysoMP↑, P450↓, cl‑PARP↑, Dose↝,
189- MFrot,  MF,    Cancer treatment by magneto-mechanical effect of particles, a review
- Review, Var, NA
CellMemb↑, lysoMP↑, ERK↑, Apoptosis↑,
216- MFrot,  MF,    Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field
- in-vitro, GBM, U87MG
lysoMP↓, CellMemb↑,
215- MFrot,  MF,    Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
- in-vitro, PC, CAF
TumVol↓, lysoMP↑, CAFs/TAFs↓, eff↑,
203- MFrot,  MF,    Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant Glioma
- vitro+vivo, GBM, U87MG
lysoMP↓, TumVol↓, eff↑, Apoptosis↑, Ca+2↑,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Bak↑, 1,   lysoMP↓, 2,   lysoMP↑, 4,   MOMP↑, 1,   necrosis↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 1,   lysosome↝, 1,   MitoP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   GADD45A↑, 1,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   ERK↑, 1,  

Migration ⓘ

Ca+2↑, 2,   CAFs/TAFs↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 2,  

Immune & Inflammatory Signaling ⓘ

LTA/TNF-β↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 2,   P450↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 2,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: lysoMP, lysosomal membrane permeabilization
4 Magnetic Field Rotating
4 Magnetic Fields
1 DTS(dibenzyl trisulphide) from Anamu
1 salinomycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:533  State#:%  Dir#:%
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