NSE Cancer Research Results
NSE, Neuron-specific enolase: Click to Expand ⟱
| Source: |
| Type: |
NSE, (or gamma-enolase or enolase 2) is a cytosolic protein consistently expressed by mature neurons and cells of neuronal origin.
NSE is commonly used as a marker for neurons and neuroendocrine cells, making it a useful tool for assessing neuronal injury and neuroendocrine tumors.
Neuron-specific enolase (NSE) has become a widely used and easily attainable laboratory assay of small cell lung cancer (SCLC). Elevated serum NSE before any therapy of SCLC patients may be a negative prognostic factor for OS and PFS.
The level of NSE correlates with tumour burden, number of metastatic sites and response to treatment.
|
Scientific Papers found: Click to Expand⟱
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
*EGR4↑, *Netrins↑, *NSE↑, *NPY↑,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Catalase↓, 1, CYP1A1↓, 1, GPx↓, 1, GSH↓, 2, GSR↓, 1, GSTs↓, 1, HO-1↓, 1, NQO1↓, 1, NRF2↓, 1, ROS↑, 1, SOD↓, 1, SOD2↓, 1, VitC↓, 1, VitE↓, 1,
Mitochondria & Bioenergetics ⓘ
AIF↑, 1, XIAP↓, 1,
Core Metabolism/Glycolysis ⓘ
SIRT1↓, 1,
Cell Death ⓘ
p‑Akt↓, 1, Bcl-2↓, 1, Casp1↓, 1, Casp3↑, 1, Casp8↑, 1, Cyt‑c↑, 1, DR5↑, 1, Fas↑, 1, FasL↑, 1, HGF/c-Met↓, 1, p‑JNK↑, 1, MAPK↓, 1, p‑MDM2↓, 1, p‑p38↑, 1,
Transcription & Epigenetics ⓘ
H3↓, 1, H4↓, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, p‑eIF2α↑, 1,
Autophagy & Lysosomes ⓘ
LC3II↑, 1,
DNA Damage & Repair ⓘ
PARP↑, 1, PCNA↓, 1,
Proliferation, Differentiation & Cell State ⓘ
CD34↓, 1, cFos↑, 1, EMT↓, 1, HDAC↓, 1, mTOR↓, 1, NOTCH1↓, 1, p‑PI3K↓, 1, PTEN↓, 1, p‑Src↓, 1, STAT3↓, 1, p‑STAT6↓, 1,
Migration ⓘ
AXL↓, 1, Cdc42↓, 1, CEA↓, 1, CLDN1↓, 1, E-cadherin↓, 1, FAK↓, 1, ITGB1↓, 1, MET↓, 1, p‑MET↓, 1, MMP2↓, 1, N-cadherin↓, 1, Rac1↓, 1, Rho↓, 1, Snail↓, 1, Tyro3↓, 1, Vim↑, 1, ZO-1↑, 1, β-catenin/ZEB1↓, 1,
Angiogenesis & Vasculature ⓘ
EGFR↑, 1, VEGF↓, 1,
Immune & Inflammatory Signaling ⓘ
ASC↓, 1, ICAM-1↓, 1, IKKα↓, 1, IL2↑, 1, IL6↓, 1, NF-kB↓, 1, p‑p65↓, 1, PD-1↓, 1,
Protein Aggregation ⓘ
NLRP3↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 1, ChemoSen↑, 1, RadioS↑, 1,
Clinical Biomarkers ⓘ
AR↓, 1, CEA↓, 1, EGFR↑, 1, IL6↓, 1, NSE↓, 1,
Functional Outcomes ⓘ
cachexia↓, 1, chemoP↑, 1,
Total Targets: 89
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
Catalase↑, 1, GPx↑, 1, GSH↑, 1, GSTs↑, 1, lipid-P↓, 1, SOD↑, 1,
Cell Death ⓘ
Casp3↓, 1,
Migration ⓘ
Netrins↑, 1,
Angiogenesis & Vasculature ⓘ
EGR4↑, 1, NPY↑, 1,
Immune & Inflammatory Signaling ⓘ
IL10↑, 1, IL1β↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1, Half-Life↝, 1,
Clinical Biomarkers ⓘ
NSE↑, 1,
Total Targets: 16
Scientific Paper Hit Count for: NSE, Neuron-specific enolase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:537 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
Home Page