Cartilage Cancer Research Results

Cartilage, Cartilage: Click to Expand ⟱
Source:
Type:
Cartilage is a flexible connective tissue found in multiple areas of the body, including joints, the ear and nose, and intervertebral discs.
The most common type of arthritis, osteoarthritis involves wear-and-tear damage to a joint's cartilage.
Chondrosarcoma is a rare type of bone cancer that develops in cartilage cells.
Cartilage Degradation: Cancer can lead to the degradation of cartilage, particularly in joint-related cancers. This degradation can result in pain and loss of function, impacting the patient's quality of life.
Biomarkers: Specific proteins and genes associated with cartilage metabolism (e.g., collagen types, aggrecan, and matrix metalloproteinases) can serve as biomarkers for cancer diagnosis and prognosis. Their expression levels may indicate the presence of malignancy or the aggressiveness of a tumor.
Scientific Papers found: Click to Expand⟱
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, Nor, NA
*iNOS↓, *IL6↓, *SOX9↑, *NF-kB↓, *MAPK↓, *Cartilage↑,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
7021- Fuc,    Fucoidan Prevents the Progression of Osteoarthritis in Rats
- in-vivo, Arthritis, NA
*Dose↝, *Cartilage↑, *TNF-α↓, *IL1β↓, *MMP1↓,
7263- Gink,    Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways
- in-vitro, ostP, SW1353
*ROS↓, *MMP13↓, *Cartilage↑,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3566- MF,    Positive and Negative Effects of Administering a Magnetic Field to Patients with Rheumatoid Arthritis (RA)
- Study, Arthritis, NA
*Inflam↓, *QoL↑, *Pain↓, *motorD↑, *toxicity↓, *Cartilage↑, *Inflam↓,
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3931- PTS,    Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies
- in-vivo, Arthritis, NA
*Inflam↓, *NLRP3↓, *GutMicro↑, *lipid-P↓, *ROS↓, *Cartilage↑, *IL6↓, *MMP13↓, *Dose↝,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
5336- TFdiG,    Theaflavin-3,3′-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways
- in-vivo, Nor, NA
*IL6↓, *TNF-α↓, *iNOS↓, *PGE1↓, *ROS↓, *Inflam↓, *PI3K↓, *Akt↓, *NF-kB↓, *MAPK↓, *Cartilage↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   OXPHOS↓, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACAA1↓, 1,   FABP4↓, 1,   Glycolysis↝, 1,   PCK1↓, 1,   PLIN1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   necrosis↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1?, 1,   Ki-67↓, 1,   STAT1↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   THBS2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD8+↓, 1,   cGAS–STING↑, 1,   FOXP3↑, 1,   IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   Imm↑, 1,   NLRP3↑, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   DDS↑, 1,   RadioS↑, 1,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS∅, 1,   PFS∅, 1,  
Total Targets: 50

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx3↑, 1,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   NRF2↑, 3,   ROS↓, 6,   SOD↑, 1,   SOD2↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   ATP↑, 1,   glucose↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   iNOS↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 2,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

SOX9↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Cartilage↑, 13,   MMP1↓, 1,   MMP13↓, 2,   MMP9↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   DCells↑, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 4,   IL6↓, 6,   IL8↓, 1,   Inflam↓, 11,   NF-kB↓, 5,   NLRP3↓, 3,   NLRP3↑, 1,   PGE1↓, 1,   PGE2↑, 1,   TNF-α↓, 7,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 2,   Dose↝, 6,   eff↑, 1,   Half-Life↑, 1,   Half-Life↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   CRP↓, 1,   IL6↓, 6,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 2,   neuroP↑, 4,   Obesity↓, 1,   OS↑, 1,   Pain↓, 3,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 2,   Strength↑, 2,   Stroke↓, 1,   toxicity↓, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,  
Total Targets: 96

Scientific Paper Hit Count for: Cartilage, Cartilage
3 Magnetic Fields
2 Urolithin
1 Caffeic acid
1 chitosan
1 Fucoidan
1 Ginkgetin
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Pterostilbene
1 Rutin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:539  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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