FABP4 Cancer Research Results
FABP4, Fatty acid-binding proteins 4: Click to Expand ⟱
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Belongs to a family of intracellular lipid-binding protein, can bind hydrophobic ligands to regulate lipid trafficking and metabolism.
Has been found to be upregulated in many malignant solid tumors, and correlated with poor prognosis.
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Scientific Papers found: Click to Expand⟱
*CEBPA↓, *PPARγ↓, *FASN↓, *SREBP1/SREBF1↓, *FABP4↓, *GLUT4↓, *β-catenin/ZEB1↑, *MMP2↓, *FGF↑, *Ca+2?,
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Review, |
Var, |
NA |
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Review, |
AD, |
NA |
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Review, |
Stroke, |
NA |
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*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
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in-vitro, |
BC, |
MDA-MB-231 |
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in-vitro, |
Nor, |
MCF10 |
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eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
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in-vitro, |
Lung, |
A549 |
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in-vivo, |
NA, |
NA |
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TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,
Showing Research Papers: 1 to 6 of 6
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
UCP1↓, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ACAA1↓, 1, FABP4↓, 2, FABP4↑, 1, PCK1↓, 1, PLIN1↓, 1, SCD1↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 2, Casp8↓, 1, Cyt‑c↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↓, 2, JAK1↓, 1, mTOR↓, 1, PI3K↓, 2, STAT↓, 1, STAT3↓, 1, STAT6↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
SIRT6↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
Ki-67↓, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
Gli1↓, 1, IGFBP3↓, 1, Ki-67↓, 1, TumCG↓, 1, TumCP↓, 1,
Migration(tgid=13) ⓘ
Cartilage↑, 1, COL4↓, 1, EMT↓, 1, ITGA11↓, 1, LAMB3↑, 1, MMP2↓, 1, MMP9↓, 1, PAK1↓, 1, THBS2↓, 1, TumCI↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
CD4+↓, 1, CD8+↓, 1, IL17↓, 1, IL22↓, 1, IL23↓, 1, IL28↓, 1, TNF-α↓, 1,
Hormonal & Nuclear Receptors(tgid=20) ⓘ
PPARα↑, 1, PPARγ↑, 3,
Drug Metabolism & Resistance(tgid=21) ⓘ
eff↑, 1, selectivity↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
BMD↑, 1,
Total Targets: 48
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 2, ARE↑, 1, HO-1↑, 1, NRF2↑, 1, ROS↓, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
compI↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
FABP4↓, 3, FASN↓, 1, SREBF2⇅, 1, SREBP1/SREBF1↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 2, iNOS↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↑, 2, AMPKα↑, 1, p‑JNK↑, 2, PKCδ↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
AntiThr↑, 1, HDAC↑, 1, RUNX2∅, 1,
DNA Damage & Repair(tgid=10) ⓘ
Telomerase↓, 1, TOP1↓, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
CEBPA↓, 2, Diff↓, 1, FGF↑, 1, Wnt↑, 1,
Migration(tgid=13) ⓘ
AntiAg↓, 2, Ca+2?, 1, COL1∅, 1, MMP2↓, 1, TGF-β1↓, 1, uPA↑, 1, β-catenin/ZEB1↑, 1,
Barriers & Transport(tgid=15) ⓘ
GLUT4↓, 1, memfluid↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
IL10↑, 1, IL1β↓, 1, IL4↑, 1, IL6↓, 2, Imm↝, 1, Inflam↓, 2, MCP1/CCL2↓, 1, TNF-α↓, 1,
Synaptic & Neurotransmission(tgid=18) ⓘ
AChE↓, 1, BChE↓, 1, BDNF↑, 1, MAOA↓, 1, MAOB↓, 1, TrkB↑, 1,
Hormonal & Nuclear Receptors(tgid=20) ⓘ
PPARγ↓, 3,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, BioAv↝, 1, ChemoSen↑, 1, Half-Life↝, 1, Synergy↑, 2,
Clinical Biomarkers(tgid=22) ⓘ
ALP∅, 1, IL6↓, 2, OCN∅, 1, TMAO↓, 1,
Functional Outcomes(tgid=23) ⓘ
Analgesic↑, 1, cardioP↑, 1, chemoP↑, 1, cognitive↑, 1, hepatoP↑, 2, neuroP↑, 1, Obesity↓, 1, Pain↓, 1, radioP↑, 1, Stroke↓, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiFungal↑, 1, AntiViral↑, 1, Bacteria↓, 1, Diar↓, 1, GutMicro↑, 1,
Total Targets: 73
Scientific Paper Hit Count for: FABP4, Fatty acid-binding proteins 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:551 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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