Akt2 Cancer Research Results
Akt2, RAC-beta serine/threonine-protein kinase: Click to Expand ⟱
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Enzyme that in humans is encoded by the AKT2 gene.
AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). miR-124 overexpression can negatively regulate AKT2. knockout of both AKT1 and AKT2 will attenuate metastasis and tumor cell growth.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
BC, |
MDA-MB-231 |
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other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, Synergy↑,
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
lipid-P↑, 1, NRF2↓, 1, ROS↑, 2, SOD↓, 1,
Metal & Cofactor Biology(tgid=2) ⓘ
IronCh↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
mtDam↑, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 2, BAD↑, 1, BAX↑, 2, Bax:Bcl2↑, 1, Bcl-2↓, 2, BID↑, 2, BOK↑, 1, cl‑Casp12↑, 1, Casp3↑, 2, cl‑Casp3↑, 1, cl‑Casp7↑, 1, Casp9↑, 3, Cyt‑c↑, 2, DR5↑, 1, FADD↑, 1, Fas↑, 1, Ferroptosis↑, 1, Mcl-1↓, 1, MDM2↑, 1, NAIP↓, 1, p38↑, 1, survivin↓, 1, XIAP↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↓, 2, Akt↑, 1, AKT1↓, 1, Akt2↓, 4, EGFR↓, 1, p‑EGFR↓, 1, ERK↓, 1, ERK↑, 1, HER2/EBBR2↓, 1, JAK2↓, 1, MAPK↓, 3, PI3K↓, 3, STAT5↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
ATF4↑, 1, cMyc↓, 1, DNMT1↓, 1, miR-155↓, 1, miR-21↓, 1, other↑, 2,
Protein Folding & ER Stress(tgid=8) ⓘ
eIF2α↑, 1, ER Stress↑, 1, PERK↑, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1/ATG6↑, 1, LC3II↑, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1, hTERT/TERT↓, 2, P53↓, 1, P53↑, 2, cl‑PARP↑, 1, Telomerase↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK2↓, 1, CDK4↓, 2, cycD1/CCND1↓, 2, Ki-67↓, 1, TumCCA↑, 3,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
IGF-1↓, 1, Ki-67↓, 1, TumCG↓, 1, TumCP↓, 3, Wnt/(β-catenin)↓, 1,
Migration(tgid=13) ⓘ
AP-1↓, 1, Ca+2↑, 1, E-cadherin↑, 1, EMT↓, 1, MMP9↓, 1, N-cadherin↓, 1, TumMeta↓, 2, Vim↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1, ECM/TCF↓, 1, Hif1a↓, 1,
Barriers & Transport(tgid=15) ⓘ
MMP↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, IL1β↓, 1, NF-kB↓, 3, PGE2↓, 1, PSA↓, 1, TNF-α↓, 1,
Hormonal & Nuclear Receptors(tgid=20) ⓘ
PPARγ↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen↑, 1, CYP1A1↑, 1, eff↝, 1, Synergy↑, 3,
Clinical Biomarkers(tgid=22) ⓘ
EGFR↓, 1, p‑EGFR↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 2, PSA↓, 1,
Functional Outcomes(tgid=23) ⓘ
Risk↓, 2,
Ingredients & Constituents(tgid=25) ⓘ
Ingr↝, 1,
Total Targets: 99
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 2, GSH↑, 1, NRF2↑, 1, ROS↓, 1, SOD↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
LDHA↑, 1, LDL↓, 1, lipidLev↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt2↓, 1, IKKα↓, 1, JNK↓, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1/ATG6↓, 1,
Migration(tgid=13) ⓘ
Ca+2↝, 1, MLC2/MYL9↝, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
VCAM-1↓, 1,
Barriers & Transport(tgid=15) ⓘ
OCLN↝, 1, TJ↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
IL1↓, 1, IL6↓, 1, IL8↓, 1, Inflam↓, 2, NF-kB↓, 2, TNF-α↓, 2,
Synaptic & Neurotransmission(tgid=18) ⓘ
BDNF↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, BioAv↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
CRP↓, 1, hs-CRP↓, 1, IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
Analgesic↑, 1, AntiArt↑, 1, AntiCan↑, 2, AntiDiabetic↑, 1, cardioP↑, 1, hepatoP↑, 1, neuroP↑, 3, toxicity↝, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiViral↑, 1, GutMicro↑, 1,
Ingredients & Constituents(tgid=25) ⓘ
Ingr↝, 4,
Total Targets: 40
Scientific Paper Hit Count for: Akt2, RAC-beta serine/threonine-protein kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:6 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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