mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱

Source:

Type:

Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.

Scientific Papers found: Click to Expand⟱

5271-

3BP,

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Review,

Var,

selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,

5280-

3BP,

Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting

in-vitro,

PC,

mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,

5277-

3BP,

3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model

in-vivo,

PC,

Panc02

mouse model

HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,

5270-

5-ALA,

PDT,

5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy

Review,

Var,

other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,

5430-

AG,

Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation

Review,

Stroke,

*cardioP↑, *MitoP↑, *ROS↓, *mtDam↓, *neuroP↓, TumAuto↓, *AntiDiabetic↑,

4394-

AgNPs,

Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways

in-vivo,

lymphoma,

OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

342-

AgNPs,

Silver nanoparticles; a new hope in cancer therapy?

Review,

NA,

ROS↑, DNAdam↑, Apoptosis↑, mtDam↑,

375-

AgNPs,

ALA,

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer

in-vitro,

PC,

Bxpc-3

 we used α-lipoic acid concentrations of 0.5 and 1 mM

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

in-vivo,

NA,

dropping 200 µL or 400 µL of a 14 ppm AgNP solution, 200 µL or 400 µL of a 0.5 mM α-lipoic acid solution, or both solutions together on the chorioallantoic membrane (CAM)

chick embryos

mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

316-

AgNPs,

Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells

in-vitro,

BC,

MCF-7

 75nm

GRP78/BiP↑, ER Stress↑, ROS↑, mtDam↑,

371-

AgNPs,

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

in-vitro,

Lung,

A549

ROS↑, mtDam↑,

368-

AgNPs,

In vitro evaluation of silver nanoparticles on human tumoral and normal cells

in-vitro,

Var,

  6.72-13.45 µg/ml

mtDam↑, LDH↓,

367-

AgNPs,

Presence of an Immune System Increases Anti-Tumor Effect of Ag Nanoparticle Treated Mice

in-vivo,

NA,

 mice

ROS↑, mtDam↑, TumCG↓,

357-

AgNPs,

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

L132

mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,

393-

AgNPs,

Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity

in-vitro,

NA,

HCT116

mtDam↑, ROS↑, TumCCA↑, Casp3↑, BAX↑, Bcl-2↓, P53↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

in-vitro,

Testi,

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

2656-

AL,

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics

in-vitro,

Park,

PC12

*antiOx↑, *Apoptosis↓, *LDH↓, ROS↓, *lipid-P↓, *mtDam↓, *MMP↓, *Cyt‑c↓, *ATP∅, *Ca+2↝, *neuroP↑,

2657-

AL,

Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases

Review,

CardioV,

Review,

AD,

*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

572-

ART/DHA,

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism

CSCs↓, mtDam↑,

3159-

Ash,

Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model

in-vitro,

Park,

SH-SY5Y

*neuroP↑, *Inflam↓, *ROS↓, *cognitive↑, *memory↑, *GPx↑, *Prx↓, *ATP↑, *Vim↓, *mtDam↓,

5552-

BBM,

Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state

in-vivo,

Stroke,

ischemia/reperfusion (I/R) injury. C57/BL6 mice

*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,

1379-

BBR,

Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells

in-vitro,

lymphoma,

TumCP↓, CDK4↓, CDK6↓, cycD1/CCND1↓, TumCCA↑, MMP↓, Ca+2↑, ATP↓, mtDam↑, Apoptosis↑, ROS↑, JNK↑, eff↓,

1399-

BBR,

Rad,

Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review

Review,

NA,

*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,

5511-

bemA,

Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation

in-vitro,

Var,

ACLY↓, PD-L1↑, mtDam↑, cGAS–STING↑, LDL↓, eff↑,

5582-

BetA,

Targeting mitochondrial apoptosis by betulinic acid in human cancers

Review,

Var,

Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,

5585-

BetA,

Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

in-vitro,

Cerv,

HeLa

in-vitro,

lymphoma,

U937

mtDam↑, TumAuto↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

5668-

BNL,

Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies

Review,

Var,

AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,

5739-

Buty,

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

Review,

Var,

GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,

2394-

CAP,

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

in-vitro,

Nor,

GES-1

(0, 2, and 8 μM)

*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,

4482-

Chit,

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

in-vitro,

Lung,

A549

in-vitro,

Liver,

HepG2

EPR↑, mtDam↑, ROS↑, Apoptosis↑,

1585-

Citrate,

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

in-vitro,

Ovarian,

SKOV3

15.93 mM

in-vitro,

Ovarian,

A2780S

16.8 mM

in-vitro,

Nor,

HEK293

Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,

1572-

Cu,

Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

Review,

NA,

eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

404-

CUR,

Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy

vitro+vivo,

Lung,

A549

mice

vitro+vivo,

Lung,

H1299

TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1↑, LC3s↑, p62↓, Ferroptosis↑,

481-

CUR,

CHr,

Api,

Flavonoid-induced glutathione depletion: Potential implications for cancer treatment

in-vitro,

Liver,

A549

in-vitro,

Pca,

PC3

in-vitro,

AML,

HL-60

GSH↓, mtDam↑, MMP↓, Cyt‑c↑,

454-

CUR,

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway

in-vitro,

GC,

MGC803

5, 10, 15, 20, 40 and 60 μM, 24, 48 and 72 h

TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,

2821-

CUR,

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Review,

Var,

*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP↑,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

in-vitro,

HCC,

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

643-

EGCG,

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

Analysis,

NA,

H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,

668-

EGCG,

The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment

Review,

BC,

MCF-7

Review,

BC,

MDA-MB-231

HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,

3241-

EGCG,

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

in-vitro,

CRC,

HCT116

0.5 ± 0.05 mm

in-vitro,

CRC,

HT29

0.8 ± 0.06 mm

in-vitro,

Liver,

HepG2

 > 1 mm

in-vitro,

Liver,

HUH7

 > 1 mm

tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,

5527-

EP,

Nanosecond pulsed electric field (nsPEF) application effects on human cells: intracellular membrane disruption and apoptosis induction

in-vivo,

Var,

mice

*Dose↓, Apoptosis↑, DNAdam↑, mtDam↑,

5495-

EP,

Irreversible electroporation in focal therapy for prostate cancer: current status and future directions

Review,

Pca,

Ca+2↑, ATP↓, mtDam↑, ROS↑, CellMemb↑,

1656-

FA,

Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Review,

Var,

tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,

2832-

FIS,

Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies

Review,

Var,

MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,

1959-

GamB,

Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells

in-vitro,

Ovarian,

in-vivo,

NA,

mice

AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,

854-

Gra,

AgNPs,

Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy

vitro+vivo,

AML,

THP1

17.34 µg/mL

in-vitro,

AML,

AMJ13

vitro+vivo,

lymphoma,

HBL

TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,

Showing Research Papers: 1 to 50 of 95
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 95

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

CD8+↑, 1,
Total Targets: 224

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 3, GPx↑, 1, GSH↑, 1, GSS↑, 1, HO-1↑, 3, Keap1↓, 1, lipid-P↓, 1, MDA↓, 1, MPO↓, 1, NQO1↑, 1, NRF2↑, 5, Prx↓, 1, ROS↓, 7, ROS↝, 1, SOD↑, 2, TBARS↓, 1, Trx↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 1, ATP∅, 1, MMP↓, 1, mtDam↓, 5, mtDam↑, 1,

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1, LDH↓, 1, LDHA↓, 1, NADPH↑, 1, PKM2↓, 1,

Cell Death ⓘ

Apoptosis↓, 1, Cyt‑c↓, 1, iNOS↓, 1,

Protein Folding & ER Stress ⓘ

ER Stress↓, 1, HSP70/HSPA5↑, 1,

Autophagy & Lysosomes ⓘ

MitoP↑, 1,

Migration ⓘ

Ca+2↝, 1, TGF-β↓, 1, Vim↓, 1,

Angiogenesis & Vasculature ⓘ

p‑eNOS↑, 1,

Immune & Inflammatory Signaling ⓘ

IL10↑, 2, IL17↓, 1, IL6↓, 1, Inflam↓, 5, TNF-α↓, 2,

Hormonal & Nuclear Receptors ⓘ

RAAS↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, Dose↓, 1, eff↑, 1,

Clinical Biomarkers ⓘ

IL6↓, 1, LDH↓, 1,

Functional Outcomes ⓘ

AntiDiabetic↑, 1, AntiTum↑, 1, cardioP↑, 3, cognitive↑, 2, memory↑, 2, neuroP↓, 1, neuroP↑, 4, toxicity↓, 1,
Total Targets: 56

Scientific Paper Hit Count for: mtDam, mitochondrial damage

14 Silver-NanoParticles
5 Propolis -bee glue
4 Curcumin
4 Honokiol
4 Lycopene
4 Selenite (Sodium)
3 3-bromopyruvate
3 Berberine
3 Betulinic acid
3 EGCG (Epigallocatechin Gallate)
3 SonoDynamic Therapy UltraSound
3 Phenethyl isothiocyanate
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 chitosan
2 Copper and Cu NanoParticles
2 Electrical Pulses
2 Hydrogen Gas
2 Hyperthermia
2 Luteolin
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Astragalus
1 Glucose
1 Alpha-Lipoic-Acid
1 entinostat
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Radiotherapy/Radiation
1 bempedoic acid
1 borneol
1 Butyrate
1 Capsaicin
1 Citric Acid
1 Chrysin
1 Disulfiram
1 Ferulic acid
1 Fisetin
1 Gambogic Acid
1 Graviola
1 doxorubicin
1 Methylene blue
1 Magnolol
1 Magnetic Field Rotating
1 Magnetic Fields
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Nimbolide
1 Pachymic acid
1 Phenylbutyrate
1 Piperlongumine
1 Plumbagin
1 Resveratrol
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenium
1 Ursolic acid
1 Urolithin
1 Wogonin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

mtDam Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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